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Total 77 results found since Jan 2013.

Transcriptional investigation of the toxic mechanisms of perfluorooctane sulfonate in rats based on an RNA-Seq approach
Chemosphere. 2023 Apr 6;329:138629. doi: 10.1016/j.chemosphere.2023.138629. Online ahead of print.ABSTRACTPerfluorooctane sulfonate (PFOS) was widely used in industrial applications before it was listed as a persistent organic pollutant by the Conference of the Parties in the Stockholm Convention in 2009. Although the potential toxicity of PFOS has been studied, its toxic mechanisms remain largely undefined. Here, we investigated novel hub genes and pathways affected by PFOS to gain new conceptions of the toxic mechanisms of PFOS. Reduced body weight gain and abnormal ultra-structures in the liver and kidney tissues were s...
Source: Chemosphere - April 8, 2023 Category: Chemistry Authors: Tianrun Wang Xuying Zhao Tianze Liu Jiguang Zhang Jing Qiu Mei Li Rui Weng Source Type: research

Minimal Residual Disease in the Management of B-Cell Acute Lymphoblastic Leukemia: A Systematic Review of Studies from Indian Settings
AbstractMinimal residual disease (MRD) has become an essential tool in the management of B-cell acute lymphoblastic leukemia (B-ALL) and aids in tailoring treatment strategies to suit specific patient needs. Although much progress has been made in this area, there is limited data on the use of MRD in the Indian context. Our objective was to identify relevant literature that discusses the utility of MRD in the management of B-cell ALL in adolescents and young adults (AYA) and adults in Indian settings. A systematic search and screening of articles were performed using the Preferred Reporting Items for Systematic Reviews and...
Source: Indian Journal of Hematology and Blood Transfusion - March 30, 2023 Category: Hematology Source Type: research

Experimental drugs in clinical trials for acute myeloid leukemia: Innovations, trends and opportunities
Expert Opin Investig Drugs. 2023 Jan 20. doi: 10.1080/13543784.2023.2171860. Online ahead of print.ABSTRACTINTRODUCTION: Acute myeloid leukemia (AML) is a heterogeneous disease characterized by many cytogenetic and molecular alterations. Due to better knowledge of the molecular basis of AML, many targeted therapies have been introduced and registered, e.g., FMS-like tyrosine kinase 3 inhibitors, isocitrate dehydrogenase 1/2 mutation inhibitors, and Bcl-2 inhibitor. Despite that, the cure for AML remains an unmet clinical need in most patients.AREAS COVERED: The review aims to present new, not yet registered drugs for AML. ...
Source: Expert Opinion on Investigational Drugs - January 20, 2023 Category: Drugs & Pharmacology Authors: Aleksandra Go łos Joanna G óra-Tybor Tadeusz Robak Source Type: research

A Systematic Literature Review of the Economic Evaluations of Treatments for Patients with Chronic Myeloid Leukemia
ConclusionsIn patients with newly diagnosed chronic myeloid leukemia, imatinib regimens were cost effective, mostly owing to the availability of generics. Nilotinib and dasatinib were generally cost effective as second-line agents for patients who were resistant or intolerant to imatinib. Though progress has been made to better characterize the cost effectiveness of first-line and second-line chronic myeloid leukemia therapies, the paucity of published cost-effectiveness studies of third-line treatments increases the uncertainty associated with economic evaluations of later lines of therapy.
Source: PharmacoEconomics - September 30, 2022 Category: Health Management Source Type: research

Dexrazoxane for preventing or reducing cardiotoxicity in adults and children with cancer receiving anthracyclines
CONCLUSIONS: Our meta-analyses showed the efficacy of dexrazoxane in preventing or reducing cardiotoxicity in adults treated with anthracyclines. In children, there was a difference between treatment groups for one cardiac outcome (i.e. for one of the definitions used for clinical heart failure and subclinical myocardial dysfunction combined) in favour of dexrazoxane. In adults, no evidence of a negative effect on tumour response rate, OS and PFS was identified; and in children, no evidence of a negative effect on tumour response rate and overall mortality was identified. The results for adverse effects varied. In children...
Source: Cochrane Database of Systematic Reviews - September 26, 2022 Category: General Medicine Authors: Esm ée C de Baat Ren ée L Mulder Saro Armenian Elizabeth Am Feijen Heynric Grotenhuis Melissa M Hudson Annelies Mc Mavinkurve-Groothuis Leontien Cm Kremer Elvira C van Dalen Source Type: research

MDS-447 A Systematic Literature Review of the Economic Burden in Patients With Myelodysplastic Syndromes
Context: Patients with higher-risk myelodysplastic syndromes (HR-MDS), if left untreated, have lower overall survival and increased economic burden. Objective: This systematic literature review (SLR) identified comprehensive evidence on the economic burden of disease among patients with low-to-high –risk MDS. Design: Literature search of English publications from 2011-2021 was conducted in Embase®, MEDLINE® and MEDLINE-In-process, including relevant conference proceedings to identify economic burden of MDS that fulfilled pre-defined inclusion criteria.
Source: Clinical Lymphoma, Myeloma and Leukemia - September 21, 2022 Category: Hematology Authors: Aditi Kataria, Evelina Jaegerskog, Ramandeep Jindal, Xiting Cao, Amit Ahuja, Ricardo Viana Tags: Myelodysplastic Syndromes Source Type: research

Cancers, Vol. 14, Pages 3778: Targeting Protein Degradation Pathways in Tumors: Focusing on Their Role in Hematological Malignancies
ski Cells must maintain their proteome homeostasis by balancing protein synthesis and degradation. This is facilitated by evolutionarily-conserved processes, including the unfolded protein response and the proteasome-based system of protein clearance, autophagy, and chaperone-mediated autophagy. In some hematological malignancies, including acute myeloid leukemia, misfolding or aggregation of the wild-type p53 tumor-suppressor renders cells unable to undergo apoptosis, even with an intact p53 DNA sequence. Moreover, blocking the proteasome pathway triggers lymphoma cell apoptosis. Extensive studies have led to the deve...
Source: Cancers - August 3, 2022 Category: Cancer & Oncology Authors: Anna Wolska-Washer Piotr Smolewski Tags: Review Source Type: research

Effectiveness and safety of isavuconazole prophylaxis for invasive fungal infections in the haematologic setting
CONCLUSION: Isavuconazole may be an effective azole for IFI prophylaxis in high-risk haematologic populations, although further studies are needed.PMID:35688453 | DOI:10.1080/16078454.2022.2076046
Source: Hematology - June 10, 2022 Category: Hematology Authors: Yang Ping Jing Hongmei Christian Bellmann M ónica Inês Tom Macmillan Neil Webb Jalal A Aram Olaf Penack Source Type: research