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Novel peanut-specific human IgE monoclonal antibodies enable screens for inhibitors of the effector phase in food allergy
ConclusionAllergen-specific human IgE mAbs, expressed from human hybridomas and specific for a clinically relevant food allergen, passively sensitize allergy effector cells central to the in vitro models of the effector phase of food allergy. Peanut reproducibly activates and induces degranulation of RBL SX-38 cells sensitized with peanut-specific human IgE mAbs. This system provides a unique screening tool to assess the efficacy of therapeutics that target allergy effector cells and inhibit food allergen-induced effector cell activation.
Source: Frontiers in Immunology - September 29, 2022 Category: Allergy & Immunology Source Type: research

Inhibitory effects of cyanidin-3-O-glucoside in black soybean hull extract on RBL-2H3 cells degranulation and passive cutaneous anaphylaxis reaction in mice.
This study provides evidence for the potential use of BSHE and C3G for the prevention or the treatment of type I allergies. PMID: 33582590 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - February 11, 2021 Category: Allergy & Immunology Authors: Hiemori-Kondo M, Morikawa E, Fujikura M, Nagayasu A, Maekawa Y Tags: Int Immunopharmacol Source Type: research

The making and function of CAR cells.
Abstract Genetically engineered T cells expressing chimeric antigen receptors (CAR) present a new treatment option for patients with cancer. Recent clinical trials of B cell leukemia have demonstrated a response rate of up to 90%. However, CAR cell therapy is frequently accompanied by severe side effects such as cytokine release syndrome and the development of target cell resistance. Consequently, further optimization of CARs to obtain greater long-term efficacy and increased safety is urgently needed. Here we high-light the various efforts of adjusting the intracellular signaling domains of CARs to these major re...
Source: Immunology Letters - June 6, 2019 Category: Allergy & Immunology Authors: Zabel M, Tauber PA, Pickl WF Tags: Immunol Lett Source Type: research

Covalent Heterobivalent Inhibitor Design for Inhibition of IgE-Dependent Penicillin Allergy in a Murine Model.
Abstract Drug allergies occur when hapten-like drug metabolites conjugated to serum proteins, through their interactions with specific IgE, trigger allergic reactions that can be life threatening. A molecule termed covalent heterobivalent inhibitor (cHBI) was designed to specifically target drug hapten-specific IgE to prevent it from binding drug-haptenated serum proteins. cHBI binds the two independent sites on a drug hapten-specific Ab and covalently conjugates only to the specific IgE, permanently inhibiting it. The cHBI design was evaluated via ELISA to measure cHBI-IgE binding, degranulation assays of rat bas...
Source: Journal of Immunology - May 16, 2019 Category: Allergy & Immunology Authors: Deak PE, Kim B, Koh B, Qayum AA, Kiziltepe T, Kaplan MH, Bilgicer B Tags: J Immunol Source Type: research

Mass Cytometry Identifies Distinct Subsets of Regulatory T Cells and Natural Killer Cells Associated With High Risk for Type 1 Diabetes
In conclusion, we show that subpopulations of Treg and NK cells were increased in individuals positive for multiple autoantibodies before disease onset. To our knowledge, these are the first results showing alterations of a subset of Tregs and NK cells in individuals with high risk for T1D. Using a multidimensional phenotyping and unbiased clustering approach we were able to identify cell populations expressing markers which are not often analyzed in a conventional flow cytometry panel. This approach made it possible to find differences that otherwise would not have been detected. Our data provides new insight into disease...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

Safety, Efficacy, and Clinical Impact of Penicillin Skin Testing in Immunocompromised Cancer Patients
ConclusionOur findings support PST use in immunocompromised hosts. The widespread use of PST in patients with cancer will allow for optimal use of antimicrobial therapy and stewardship, which are vital in a population at increased risk for infections.
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 28, 2019 Category: Allergy & Immunology Source Type: research

Evaluation of Morbidity and Mortality from Drug Allergies in Patient with Acute Myeloid Leukemia
Patients with a drug allergy are known to have increased morbidity and mortality. Patients with Acute Myeloid Leukemia (AML) are known to have recurrent severe infections due to immunosuppression from chemotherapy. The prevalence of drug allergy in patients with AML and its effect on morbidity and mortality has not been previously studied.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Maria Paula Henao, Faoud Terrence Ishmael Source Type: research

Inhibitory effects of 2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate on allergic inflammatory responses in rat basophilic leukemia cells.
In this study, we investigated the effects of coumarin derivatives on mast cell degranulation. The effect of coumarin derivatives on degranulation in rat basophilic leukemia (RBL)-2H3 cells was determined by a β-hexosaminidase assay and histamine assay. A coumarin derivative 1 (C1), 2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate, inhibited degranulation in a dose-dependent manner and demonstrated maximum therapeutic effect when used at 25μM. Additionally, these compounds inhibited the phosphorylation of the extracellular signal-regulated kinase (ERK) pathway. Taken together, these results indicate that 2-oxo-2H-chromen-4...
Source: International Immunopharmacology - May 17, 2017 Category: Allergy & Immunology Authors: Yoo G, Lee K, Lee DC Tags: Int Immunopharmacol Source Type: research

Red Gram (Cajanus cajan) Proteins Induce Hypersensitivity in BALB/c Mice following Oral Exposure and Cause Mediators Release from RBL-2H3 Cells.
Abstract The prevalence of food allergy is an increasing health concern throughout the world. Among different types of food responsible for causing allergies, legumes contribute a major proportion. Lack of in depth mechanistic information on the allergenic potential through oral route of several leguminous food crops especially Red gram (Cajanus cajan) led to this work. Allergenic potential of red gram crude protein extract was evaluated in BALB/c mice following oral exposure to explore clinical symptoms, thymic stromal lymphopoitin (TSLP), mouse mast cell protease-1 (mMCPT-1) and histamine levels. Also, Rat Basop...
Source: Inflammation and Allergy Drug Targets - January 31, 2014 Category: Allergy & Immunology Authors: Kumar S, Misra A, Verma AK, Sharma A, Das M, Dwivedi PD Tags: Inflamm Allergy Drug Targets Source Type: research