• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Pregnancy and neonatal outcomes among women with early-onset colorectal cancer: a nationwide case-control study
EClinicalMedicine. 2023 Apr 13;59:101963. doi: 10.1016/j.eclinm.2023.101963. eCollection 2023 May.ABSTRACTBACKGROUND: Early-onset colorectal cancer has risen worldwide, leaving more women with colorectal cancer at reproductive ages. We aimed to investigate the risk of adverse pregnancy and neonatal outcomes among women with early-onset colorectal cancer.METHODS: We conducted a nationwide, matched case-control study of maternal/pregnancy outcomes including pre-eclampsia and Cesarean delivery (C-section) as well as neonatal outcomes including preterm birth among 207 births in women with early-onset colorectal cancer (ages 18...
Source: Cancer Control - May 1, 2023 Category: Cancer & Oncology Authors: Yin Cao Stephanie Zhao Tomas S Bexelius Jonas S öderling Mengyao Shi Bjorn Roelstraete Barbara B Warner Olof Stephansson Jonas F Ludvigsson Source Type: research

Methylated Septin9 (m < em > SEPT9 < /em > ): A promising blood-based biomarker for the detection and screening of early-onset colorectal cancer
Cancer Res Commun. 2022 Feb;2(2):90-98. doi: 10.1158/2767-9764.crc-21-0142. Epub 2022 Feb 11.ABSTRACTEarly-onset colorectal cancer (EOCRC), defined as a diagnosis under age 50, is an emerging public health burden. As many of these individuals fall outside of screening guidelines, the development of a minimally invasive, accurate screening modality for this population is warranted. We evaluated the FDA-approved blood-based biomarker methylated Septin9 (mSEPT9) test as screening tool for EOCRC. EOCRC plasma, healthy plasma, and serum-free conditioned media from cancer cell lines was collected. Cell-free DNA (cfDNA) was isola...
Source: Cell Research - August 22, 2022 Category: Cytology Authors: Holli A Loomans-Kropp Yurong Song Manish Gala Aparna R Parikh Emily E Van Seventer Rocio Alvarez Megan P Hitchins Robert H Shoemaker Asad Umar Source Type: research

Colorectal cancer screening with fecal immunochemical testing: a community-based, cross-sectional study in average-risk individuals in Nigeria
This study aimed to assess the fecal immunochemical test as a colorectal cancer screening modality in average-risk individualS in Nigeria.METHODS: A population-based, cross-sectional study of qualitative fecal immunochemical test-based colorectal cancer screening was done in asymptomatic, average-risk participants aged 45-75 years in three states in Nigeria (Osun, Kwara, and Lagos). Participants were invited to enrol using age-stratified and sex-stratified convenience sampling following community outreach. Exclusion criteria included a personal history of colorectal cancer or rectal bleeding in the previous 6 months, a fir...
Source: Cancer Control - June 17, 2022 Category: Cancer & Oncology Authors: Olusegun I Alatise Anna J Dare Patrick A Akinyemi Fatimah B Abdulkareem Samuel A Olatoke Gregory C Knapp T Peter Kingham African Research for Oncology Colorectal Screening Early Detection Group Source Type: research

Janssen Presents Study Results Showing Clinical Efficacy for TREMFYA ® (guselkumab) and Long-Term Safety Profile for STELARA® (ustekinumab) for Patients Living with Inflammatory Bowel Disease at Digestive Disease Week® 2022
SPRING HOUSE, PENNSYLVANIA, May 24, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new data from the Phase 2 GALAXI 1 clinical trial of TREMFYA® (guselkumab) in adult patients with moderately to severely active Crohn’s disease (CD), and from three separate long-term pooled analyses of adult patients with ulcerative colitis (UC) and CD treated with STELARA® (ustekinumab).1,2,3,4 These data are being presented as oral and poster presentations and are among 29 Janssen abstracts presented during the Digestive Disease Week® (DDW) meeting taking place in person and virtually in San Di...
Source: Johnson and Johnson - May 24, 2022 Category: Pharmaceuticals Source Type: news

Physical activity participation and the risk of chronic diseases among South Asian adults: protocol for a systematic review and meta-analysis
DiscussionThis review will summarise the strength of the association between physical activity and selected chronic diseases and their markers among South Asian adults 40  years or older. The findings will provide an evidence base to guide public health policy and interventions in the South Asian region and to inform future research to address the rising burden of chronic diseases.Systematic review registrationPROSPEROCRD42018096505
Source: Systematic Reviews - October 30, 2018 Category: International Medicine & Public Health Source Type: research

Colorectal Cancer Screening in Black Men: Recommendations for Best Practices
This article is part of a supplement entitled African American Men's Health: Research, Practice, and Policy Implications, which is sponsored by the National Institutes of Health.
Source: American Journal of Preventive Medicine - October 18, 2018 Category: International Medicine & Public Health Source Type: research

Recommendations for Randomised Trials in Surgical Oncology
Trials of surgical procedures in the treatment of malignant disease face a unique set of challenges. This review aimed to describe recommendations for the design, delivery and reporting of randomised trials in surgical oncology. A literature search was carried out without date limits to identify articles related to trial methodology research in surgery and surgical oncology. A narrative review was framed around two open National Institute of Health Research portfolio trials in colon and rectal cancer: the STAR-TREC trial (ISRCTN14240288) and the ROCCS trial (ISRCTN46330337).
Source: Clinical Oncology - October 30, 2017 Category: Radiology Authors: J.C. Glasbey, E.L. Magill, K. Brock, S.P. Bach Tags: Overview Source Type: research

Top Companies in Genomics
From portable genome sequencers until genetic tests revealing distant relations with Thomas Jefferson, genomics represents a fascinatingly innovative area of healthcare. As the price of genome sequencing has been in free fall for years, the start-up scene is bursting from transformative power. Let’s look at some of the most amazing ventures in genomics! The amazing journey of genome sequencing Genome sequencing has been on an amazing scientific as well as economic journey for the last three decades. The Human Genome Project began in 1990 with the aim of mapping the whole structure of the human genome and sequencing it. ...
Source: The Medical Futurist - May 30, 2017 Category: Information Technology Authors: nora Tags: Genomics Personalized Medicine AI artificial intelligence bioinformatics cancer DNA dna testing DTC gc3 genetic disorders genetics genome sequencing personal genomics precision medicine Source Type: blogs

New Bill Seeks to Create First Mesothelioma Registry in US
People diagnosed with mesothelioma often feel there is little public information about the asbestos-related cancer. Several existing state cancer registries focus on more common cancers, including lung, breast, prostate and colorectal. While there are more than 221,000 new lung cancer cases annually in the U.S., mesothelioma is rare — about 3,000 new cases each year. The Surveillance, Epidemiology, and End Results (SEER) Program, a national cancer registry, tracks incidence rates by state, but it does not track new cases of mesothelioma at a national level. While it publishes fact sheets with information about new ca...
Source: Asbestos and Mesothelioma News - August 12, 2015 Category: Environmental Health Authors: Beth Swantek Tags: Legislation, Laws & Litigation Source Type: news