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Cancer: Breast Cancer
Therapy: Stem Cell Therapy
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Total 1405 results found since Jan 2013.
The PML1-WDR5 axis regulates H3K4me3 marks and promotes stemness of estrogen receptor-positive breast cancer
Res Sq. 2023 Sep 8:rs.3.rs-3266720. doi: 10.21203/rs.3.rs-3266720/v1. Preprint.ABSTRACTThe alternative splicing of PML precursor mRNA gives rise to various PML isoforms, yet their expression profile in breast cancer cells remains uncharted. We discovered that PML1 is the most abundant isoform in all breast cancer subtypes, and its expression is associated with unfavorable prognosis in estrogen receptor-positive (ER+) breast cancers. PML depletion reduces cell proliferation, invasion, and stemness, while heterologous PML1 expression augments these processes and fuels tumor growth and resistance to fulvestrant, an FDA-approv...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Hung-Ying Kao Chun-Peng Pai Han Wang Neel Agarwal Joshua Adams Zhenghao Liu Darcie Seachrist Ruth Keri William Schiemann Source Type: research
An early neoplasia index (ENI10), based on molecular identity of CD10 cells and associated stemness biomarkers, is a predictor of patient outcome in many cancers
Cancer Res Commun. 2023 Sep 14. doi: 10.1158/2767-9764.CRC-23-0196. Online ahead of print.ABSTRACTAn accurate estimate of patient survival at diagnosis is critical to plan efficient therapeutic options. A simple and multi-application tool is needed to move forward the precision medicine era. Taking advantage of the broad and high CD10 expression in stem and cancers cells, we evaluated the molecular identity of aggressive cancer cells. We used epithelial primary cells and developed a breast cancer stem cells-based progressive model. The superiority of the early-transformed isolated molecular index was evaluated by large-sca...
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Boris Guyot Flora Cl ément Youenn Drouet Xenia Schmidt Sylvain Lefort Emmanuel Delay Isabelle Treilleux Jean-Philippe Foy Sandrine Jeanpierre Emilie Thomas Janice Kielbassa Laurie Tonon Helen He Zhu Pierre Saintigny Wei-Qiang Gao Arnaud de la Fouchardier Source Type: research
Ionizing radiation normalizes the features of active breast cancer stromal fibroblasts and suppresses their paracrine pro-carcinogenic effects
CONCLUSION: Together, these findings indicate that X-rays can normalize the features of active breast stromal fibroblasts through promoting senescence without SASP.PMID:37672859 | DOI:10.1016/j.tranon.2023.101780
Source: Translational Oncology - September 6, 2023 Category: Cancer & Oncology Authors: Abdelilah Aboussekhra Noura N Alraouji Falah H Al-Mohanna Huda Al-Khalaf Source Type: research
Mechanisms Of Breast Cancer Progression Induced BY Environment-Polluting ARYL Hydrocarbon Receptor Agonists
The objectives of this review are a) to summarize recent original experimental, preclinical, and clinical studies on the biological mechanisms of AhR agonists which interfere with the regulation of breast endocrine functions, and b) to examine the biological effects of AhR ligands and their impact on breast cancer development and progression. We discuss biological mechanisms of action in cell viability, cell cycle, proliferation, epigenetic changes, epithelial to mesenchymal transition, and cell migration and invasion. In addition, we examine the effects of AhR ligands on angiogenic processes, metastasis, chemoresistance, ...
Source: Biochemical Pharmacology - September 2, 2023 Category: Drugs & Pharmacology Authors: Noelia V Miret Carolina A Pontillo Sol Buj án Florencia A Chiappini Andrea S Randi Source Type: research
Single-cell RNA reveals a tumorigenic microenvironment in the interface zone of human breast tumors
CONCLUSIONS: Our work identified a unique tumorigenic microenvironment of the interface zone and allowed for deeper insights into the tumor microenvironment of breast cancer that will serve as a helpful resource for advancing breast cancer diagnosis and therapy.PMID:37644609 | DOI:10.1186/s13058-023-01703-7
Source: Cell Research - August 29, 2023 Category: Cytology Authors: Wei Yang Meiyu Xu Shuoqi Xu Qingxian Guan Shuaiming Geng Juanhong Wang Wei Wei Hongwei Xu Ying Liu Yong Meng Ming-Qing Gao Source Type: research
Epstein-Barr Viral Infection and the Risk for Breast Cancer: A Systematic Review
Conclusions: A previous EBV infection might be associated with a higher risk for breast malignancy. The most common type is invasive cancer. It mainly affects women and geographical variances are observed. More studies are necessary to elucidate the role of EBV in the mechanisms of breast cancer. Also, it is crucial to improve the prevention and treatment strategies.PMID:37637768 | PMC:PMC10452945 | DOI:10.18502/ijhoscr.v17i2.12650
Source: Cancer Control - August 28, 2023 Category: Cancer & Oncology Authors: Arjola Agolli Angela Ishak Mahima Viswanathan Edzel Lorraine Co Jeevan Shivakumar Olsi Agolli Source Type: research
Evaluation of the Role of Tumor-Infiltrating Lymphocytes and CD8 < sup > + < /sup > Cytotoxic Lymphocytes in the Survival of Patients with Breast Cancer
Conclusion: Our findings showed that in cases of CD8+ cytotoxic lymphocytes in tumors, the OS of the patients will be enhanced which can act as an independent factor.PMID:37638284 | PMC:PMC10448926 | DOI:10.18502/ijhoscr.v17i1.11708
Source: Cell Research - August 28, 2023 Category: Cytology Authors: Shahram Shojaei Mozaffar Aznab Amirmasoud Rahimi Seyed Mojtaba Ahmadi Kumars Eslampia Arash Golpazir Masoud Iravani Source Type: research
The 5-Year Disease-Free Survival of Third Generation Aromatase Inhibitor for Postmenopausal Women with HR-Positive HER2-Negative Non-Metastatic Breast Cancer
Conclusion: 5-year letrozole administration could be proposed as first-line therapy for postmenopausal women with HR-positive HER2-negative BC. A considerable subject and long-term follow-up are needed for validation.PMID:37638281 | PMC:PMC10448920 | DOI:10.18502/ijhoscr.v17i1.11713
Source: Cell Research - August 28, 2023 Category: Cytology Authors: Ria Etikasari Tri Murti Andayani Dwi Endarti Kartika Widayati Taroeno-Hariadi Source Type: research
Acyl-CoA Medium-Chain Synthetase-3 (ACSM3) Is Regulated by Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) and Inhibits Proliferation, Motility and Stem Cell Properties of Breast Invasive Carcinoma
CONCLUSION: We found that ACSM3 was regulated by IGF2BP3 and attenuated BRCA proliferation, invasion and stem cell properties. The role of ACSM3 in BRCA was first revealed, which provides a novel target for treatment.PMID:37625834
Source: Clinical Breast Cancer - August 25, 2023 Category: Cancer & Oncology Authors: Wenjing Zhu Xiuxing Wei Meijiao Fang Source Type: research
Photothermal hyaluronic acid composite hydrogel targeting cancer stem cells for inhibiting recurrence and metastasis of breast cancer
Int J Biol Macromol. 2023 Aug 18:126358. doi: 10.1016/j.ijbiomac.2023.126358. Online ahead of print.ABSTRACTRecurrence and metastasis have been recognized as a great challenge in cancer treatment. Cancer stem cells (CSCs), as a small subset of cancer cells, are closely associated with tumor metastasis and recurrence due to their resistance and multi-differentiation characteristics. Herein, we developed a local injectable hyaluronic acid (HA) composite hydrogel (HAAG) that targets CSCs, which can continuously release all-trans retinoic acid (ATRA) and gold nanoparticles (AuNPs) at tumor sites. The composite hydrogel was end...
Source: International Journal of Biological Macromolecules - August 20, 2023 Category: Biochemistry Authors: Teng Wang Yang Yu Bingjie Wang Tianze Jiang Xin Meng Xia Zhao Source Type: research
Effects of bromodomain and extra-terminal inhibitor JQ1 and interleukin-6 on breast cancer cells
CONCLUSION: Analysis of gene expression indicated that JQ1 and IL-6 synergistically increase SNAIL expression and decrease c-MYC expression in MCF-7 cells. So, the BET proteins are promising, novel therapeutic targets in late-stage breast cancers. BET inhibitors similar to JQ1 show promise as therapeutic candidates for breast cancers, especially when triple-negative breast cancer cells are increased and/or tumor-promoting factors like IL-6 exist in the tumor microenvironment.PMID:37589934 | DOI:10.1007/s11033-023-08718-5
Source: Mol Biol Cell - August 17, 2023 Category: Molecular Biology Authors: Atefeh Sharifhoseini Masoud Heshmati Amin Soltani Mahshad Entezam Hedayatollah Shirzad Morteza Sedehi Babri A Judd Mohammad-Saeid Jami Mahdi Ghatrehsamani Source Type: research
