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Prevalence of Cerebral Small-Vessel Disease in Long-Term Breast Cancer Survivors Exposed to Both Adjuvant Radiotherapy and Chemotherapy.
CONCLUSION: More CMBs were found in the aRCeBCS group than in the population-based controls. These vascular lesions potentially mark cerebrovascular frailty that could partially explain the well-documented association between chemotherapy and cognitive dysfunction. No support was found for a radiotherapy-related origin of CMBs. PMID: 25559803 [PubMed - as supplied by publisher]
Source: Clinical Genitourinary Cancer - January 5, 2015 Category: Cancer & Oncology Authors: Koppelmans V, Vernooij MW, Boogerd W, Seynaeve C, Ikram MA, Breteler MM, Schagen SB Tags: J Clin Oncol Source Type: research

Case Report Snowflakes in the heart: an ultrasonic marker of severe hypercoagulability
A 58-year-old woman with metastatic breast cancer and Coombs-positive autoimmune haemolytic anaemia presented in April, 2014, after developing right arm weakness 8 hours into a long-haul flight. ECG and telemetry showed normal sinus rhythm. Brain MRI showed multiple small foci of restricted diffusion in the anterior, middle, and posterior cerebral artery territories suggestive of cardioembolic stroke, with widespread microhaemorrhages. Carotid ultrasound showed normal carotid and vertebral artery anatomy.
Source: LANCET - January 16, 2015 Category: Journals (General) Authors: Louis W Wang, John J Grygiel, John H O'Neill, Diane Fatkin, Michael P Feneley Tags: Case Report Source Type: research

Smoking Causes More Kinds Of Deaths Than We Ever Thought
Breast cancer, prostate cancer, and even routine infections. A new report ties these and other maladies to smoking and says an additional 60,000 to 120,000 deaths each year in the United States are probably due to tobacco use. The study by the American Cancer Society and several universities, published in Thursday's New England Journal of Medicine, looks beyond lung cancer, heart disease and other conditions already tied to smoking, and the 480,000 U.S. deaths attributed to them each year. "Smokers die, on average, more than a decade before nonsmokers," and in the U.S., smoking accounts for one of every five deaths, Dr. ...
Source: Science - The Huffington Post - February 12, 2015 Category: Science Source Type: news

HRT increases ovarian cancer risk by small amount
Conclusion This systematic review and meta-analysis showed that ovarian cancer risk was significantly increased in current HRT users, even in those with less than five years of HRT use (the average was three years). In ex-users, risks decreased the longer ago HRT use had stopped, but risks during the first few years after stopping remained significant. Furthermore, about a decade after stopping, long-duration hormone therapy use (average nine years of HRT use), there still seemed to be a small excess risk. The review has a few limitations, however. The main one is that the review was heavily influenced by just two of t...
Source: NHS News Feed - February 13, 2015 Category: Consumer Health News Tags: Cancer Medication Older people Source Type: news

Smoking's Death Toll May Be Higher Than Anyone Knew
Tobacco's link to lung cancer, stroke and heart attack is well-known. But smokers are also more likely to die from kidney failure, infections and breast cancer, a revised tally suggests.» E-Mail This
Source: NPR Health and Science - February 12, 2015 Category: Consumer Health News Authors: Richard Harris Source Type: news

Menopause-related hot flashes and night sweats can last for years
According to conventional medical wisdom, menopause-related hot flashes fade away after six to 24 months. Not so, says a new study of women going through menopause. Hot flashes last, on average, for about seven years and may go on for 11 years or more. The hormonal roller coaster that comes with the end of a woman’s childbearing years can trigger a range of symptoms. Up to 80% of women going through menopause experience hot flashes. Hot flashes, also known as vasomotor symptoms, are often described as a sudden sensation of heat in the chest, face, and head followed by flushing, perspiration, and sometimes chills. Whe...
Source: New Harvard Health Information - February 23, 2015 Category: Consumer Health News Authors: Nancy Ferrari Tags: Menopause Women's Health hot flashes night sweats Source Type: news

Prevalence of Cerebral Small-Vessel Disease in Long-Term Breast Cancer Survivors Exposed to Both Adjuvant Radiotherapy and Chemotherapy Breast Cancer
Conclusion More CMBs were found in the aRCeBCS group than in the population-based controls. These vascular lesions potentially mark cerebrovascular frailty that could partially explain the well-documented association between chemotherapy and cognitive dysfunction. No support was found for a radiotherapy-related origin of CMBs.
Source: Journal of Clinical Oncology - February 18, 2015 Category: Cancer & Oncology Authors: Koppelmans, Vernooij, Boogerd, Seynaeve, Ikram, Breteler, Schagen Tags: Radiation, Chemotherapy Breast Cancer Source Type: research

Menopausal hormone therapy and ovarian cancer: putting risk into perspective
The wide use of menopausal hormone therapy (MHT) rapidly declined a decade ago after the results of the Women's Health Initiative (WHI) showed that women treated with conjugated equine estrogens plus medroxyprogesterone acetate had an increased risk of breast cancer, coronary heart disease, stroke, and pulmonary embolism [1]. Increased ovarian cancer risk was not reported in the randomized WHI intervention trial nor in the extended poststopping phases of the study [2].
Source: Maturitas - February 26, 2015 Category: Primary Care Authors: Faustino R. Pérez-López, Margaret Rees Source Type: research

Couples Over 50 Are More Likely To Divorce When The Wife Gets Sick, Study Suggests
Couples vow on their wedding days to love one another in sickness and in health, but apparently, that's not a promise they always keep. A new study published in the Journal of Health and Social Behavior has found that when a wife gets sick, marriages are more likely to end in divorce than "till death do us part." Researchers at Iowa State University looked at 2,701 couples over the age of 50 from the Health and Retirement Study, conducted between 1992 and 2010. They wanted to see if a diagnosis of cancer, heart problems, lung disease and/or stroke could potentially affect marital outcomes. And it did, but only for women: ...
Source: Healthy Living - The Huffington Post - March 5, 2015 Category: Consumer Health News Source Type: news

More Evidence That Hormone Therapy Might Not Help Women's Hearts
Review also found raised risk of stroke for some, although timing of use may be a key factor
Source: Cancercompass News: Breast Cancer - March 12, 2015 Category: Cancer & Oncology Source Type: news

Bioidentical hormones, menopausal women, and the lure of the “natural” in U.S. anti-aging medicine
Publication date: May 2015 Source:Social Science & Medicine, Volume 132 Author(s): Jennifer R. Fishman , Michael A. Flatt , Richard A. Settersten Jr. In 2002, the Women's Health Initiative, a large-scale study of the safety of hormone replacement therapy (HRT) for women conducted in the United States, released results suggesting that use of postmenopausal HRT increased women's risks of stroke and breast cancer. In the years that followed, as rates of HRT prescription fell, another hormonal therapy rose in its wake: bioidentical hormone replacement therapy (BHRT). Anti-aging clinicians, the primary prescribers of ...
Source: Social Science and Medicine - March 19, 2015 Category: Psychiatry & Psychology Source Type: research

Precision medicine is coming, but not anytime soon
President Obama’s announcement of a Precision Medicine Initiative was one of the few items in this year’s State of the Union address to garner bipartisan support. And for good reason. Precision medicine, also known as personalized medicine, offers the promise of health care — from prevention to diagnosis to treatment — based on your unique DNA profile. Who wouldn’t want that? We’ve already had a taste of precision medicine. Relatively low-tech therapies like eyeglasses, orthotic devices, allergy treatments, and blood transfusions have long been personalized for the individual. Genetic analysis o...
Source: New Harvard Health Information - March 26, 2015 Category: Consumer Health News Authors: Beverly Merz Tags: Health care personalized health care precision medicine Source Type: news

HyDRA: gene prioritization via hybrid distance-score rank aggregation
Summary: Gene prioritization refers to a family of computational techniques for inferring disease genes through a set of training genes and carefully chosen similarity criteria. Test genes are scored based on their average similarity to the training set, and the rankings of genes under various similarity criteria are aggregated via statistical methods. The contributions of our work are threefold: (i) first, based on the realization that there is no unique way to define an optimal aggregate for rankings, we investigate the predictive quality of a number of new aggregation methods and known fusion techniques from machine lea...
Source: Bioinformatics - April 2, 2015 Category: Bioinformatics Authors: Kim, M., Farnoud, F., Milenkovic, O. Tags: SYSTEMS BIOLOGY Source Type: research

Up-regulation of VCAM1 Relates to Neuronal Apoptosis After Intracerebral Hemorrhage in Adult Rats.
Abstract Vascular cell adhesion molecule 1 (VCAM1) is a member of the Immunoglobulin superfamily and encodes a cell surface sialoglycoprotein expressed in cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion, facilitates the downstream signaling, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Accumulating evidence has demonstrated that VCAM1 exerts an anti-apoptotic effect in several tumor tissues such as ovarian cancer and breast cancer. Intracerebral hemorrhage (ICH) is the second most common subtype of stroke with high mo...
Source: Neurochemical Research - April 14, 2015 Category: Neuroscience Authors: Zhang D, Yuan D, Shen J, Yan Y, Gong C, Gu J, Xue H, Qian Y, Zhang W, He X, Yao L, Ji Y, Shen A Tags: Neurochem Res Source Type: research

Relationship between alcohol-attributable disease and socioeconomic status, and the role of alcohol consumption in this relationship: a systematic review and meta-analysis
Conclusions: Despite some limitations to our review, we have described relationships between socioeconomic status and a range of alcohol-attributable conditions, and explored the mediating and interacting effects of alcohol consumption where feasible. However, further research is needed to better characterise the relationship between SES, alcohol consumption and alcohol-attributable disease risk so as to gain a greater understanding of the mechanisms and pathways that influence the differential risk in harm between people of low and high socioeconomic status.
Source: BMC Public Health - April 18, 2015 Category: Consumer Health News Authors: Lisa JonesGeoff BatesEllie McCoyMark Bellis Source Type: research