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Early-life farm exposures and eczema among adults in the Agricultural Lung Health Study
CONCLUSIONS: In utero and childhood farming exposures are associated with decreased odds of having eczema with atopy in adults.PMID:36569583 | PMC:PMC9784317 | DOI:10.1016/j.jacig.2022.06.002
Source: Clinical Lung Cancer - December 26, 2022 Category: Cancer & Oncology Authors: Annah B Wyss Thanh T Hoang Hilde K Vindenes Julie D White Sinjini Sikdar Marie Richards Laura E Beane-Freeman Christine G Parks Mikyeong Lee David M Umbach Stephanie J London Source Type: research

Characteristics of annual mold variations and association with childhood allergic symptoms/diseases via combining surveys and home visit measurements
This study aimed to characterize household fungal diversity and its annual temporal and spatial variations. We developed combined cross-sectional survey, repeated air sampling around a year, and DNA sequencing methods. The questionnaire survey was conducted in 2019, and 4943 valid cases were received from parents; a follow-up case-control study (11 cases and 12 controls) was designed, and onsite measurements of indoor environments were repeated in typical summer, transient season, and winter; dust from floor and beddings in children's room were collected and ITS based DNA sequencing of totally 68 samples was conducted. Res...
Source: Cancer Control - September 28, 2022 Category: Cancer & Oncology Authors: Chenqiu Du Baizhan Li Wei Yu Runming Yao Jiao Cai Bicheng Li Yinghui Yao Yujue Wang Min Chen Emmanuel Essah Source Type: research

On endocrine disruption at the workplace – how to get from suggestive to conclusive evidence?
Unusual clusters and outbreaks of reproductive disorders during past decades remind us of the devastating health consequences and human suffering to which exposure to industrial chemicals and pharmaceuticals may give rise. Birth defects caused by gestational exposure to thalidomide, vaginal cancer by diethylstilbestrol, azoospermia by dibromochloropropane, cerebral palsy by methyl mercury, and fetal wasting syndrome by chlorinated biphenyls are all inscribed in medical history as tragic mementos of ignorance and neglect in the past (1). In parallel with the fast-increasing entrance of women into the workforce, interest ...
Source: Scandinavian Journal of Work, Environment and Health - April 16, 2020 Category: Occupational Health Tags: Editorial Source Type: research

A Bidirectional Label Propagation Based Computational Model for Potential Microbe-Disease Association Prediction
Discussion There are numerous microbial communities inhabited in the human body, which is critical to human health. The relationship between human microbiome and diseases received much attention from both medical and bioinformatics community recently. However, traditional methods to detect their association is costly and labor-intensive. Thus, we proposed here a new computational model called NBLPIHMDA to infer potential microbe-disease associations. NBLPIHMDA first combined known microbe-disease associations in HMDAD and the Gaussian interaction profile kernel similarity to construct disease similarity network and microb...
Source: Frontiers in Microbiology - April 8, 2019 Category: Microbiology Source Type: research

Genetic polymorphisms of Th2 interleukins, history of asthma or eczema and childhood acute lymphoid leukaemia: Findings from the ESCALE study (SFCE)
ConclusionThis study provides a new insight into the relationship between allergic symptoms and childhood acute lymphoid leukaemia, by suggesting this inverse association could be limited to children carrying certain genetic polymorphisms. If confirmed, these results could help better understand the biological mechanisms involved in the development of childhood acute lymphoid leukaemia.
Source: Cancer Epidemiology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Residential Air Pollution and Associations with Wheeze and Shortness of Breath in Adults: A Combined Analysis of Cross-Sectional Data from Two Large European Cohorts
Conclusion: Exposure to PM and NO2 air pollution was associated with the prevalence of wheeze and shortness of breath in this large study, with stronger associations between PM2.5 and both outcomes among lower- versus higher-income participants. https://doi.org/10.1289/EHP1353 Received: 13 November 2016 Revised: 10 August 2017 Accepted: 14 August 2017 Published: 29 September 2017 Address correspondence to D. Doiron, Research Institute of the McGill University Health Centre, 2155 rue Guy, office 458, Montreal, Canada, H3H 2R9. Telephone: 1-514-934-1934 (ex. 71688). Email: ddoiron@maelstrom-research.org Supplemental Ma...
Source: EHP Research - September 29, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Maternal Exposure of BALB/c Mice to Indoor NO2 and Allergic Asthma Syndrome in Offspring at Adulthood with Evaluation of DNA Methylation Associated Th2 Polarization
Conclusions: Maternal exposure to indoor environmental NO2 causes allergic asthma-related consequences in offspring absent any subsequent lung provocation and potentiates the symptoms of allergic asthma in adult offspring following postnatal allergic sensitization and challenge; this response is associated with the Th2-based immune response and DNA methylation of the IL4 gene. https://doi.org/10.1289/EHP685 Received: 19 June 2016 Revised: 07 June 2017 Accepted: 19 June 2017 Published: 13 September 2017 Address correspondence to N. Sang, College of Environment and Resource, Shanxi University, Taiyuan, Shanxi 030006, P...
Source: EHP Research - September 13, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Exposure to Traffic-Related Air Pollution and Serum Inflammatory Cytokines in Children
Conclusion: Our results indicate alterations in systemic inflammatory markers in 8-y-old children in relation to early-life exposure to traffic-related air pollution. https://doi.org/10.1289/EHP460 Received: 04 May 2016 Revised: 20 October 2016 Accepted: 07 November 2016 Published: 16 June 2017 Address correspondence to O. Gruzieva, Karolinska Institutet, Institute of Environmental Medicine, Nobels väg 13 Box 210, SE-17177, Stockholm, Sweden. Telephone: 46 8 524 80022. Fax: 46 8 304571. E-mail: olena.gruzieva@ki.se Supplemental Material is available online (https://doi.org/10.1289/EHP460). The authors declare they h...
Source: EHP Research - June 16, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Research Source Type: research

Racial and Ethnic Disparities in Research Studies: The Challenge of Creating More Diverse Cohorts
This reporting project was funded through a grant provided by the Reporting Award at New York University’s Arthur L. Carter Journalism Institute. Background image: Bahri Altay/Shutterstock About This Article open Citation: Konkel L. 2015. Racial and ethnic disparities in research studies: the challenge of creating more diverse cohorts. Environ Health Perspect 123:A297–A302; http://dx.doi.org/10.1289/ehp.123-A297 Published: 1 December 2015 PDF Version (873 KB) Minority populations are much less likely than their white counterparts to be included in studies on environmentally related diseases, even t...
Source: EHP Research - December 1, 2015 Category: Environmental Health Authors: Web Admin Tags: Featured News Spheres of Influence December 2015 Source Type: research