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Total 37 results found since Jan 2013.
Impact of Concomitant Cardiovascular Therapies on Efficacy and Safety of Relugolix vs Leuprolide: Subgroup Analysis from HERO Study in Advanced Prostate Cancer
CONCLUSION: Relugolix suppressed testosterone and was generally well tolerated when given with concomitant CV agents.TRIAL REGISTRATION: Clinical Trial ID NCT03085095.PRIOR PRESENTATION: Data presented at 15th Annual Genitourinary Cancers Symposium; February 17-19, 2022, San Francisco, CA, USA [Abstract 101, Poster board E11]. The published abstract from this presentation can be found at https://ascopubs.org/doi/10.1200/JCO.2022.40.6_suppl.101 .PMID:37713020 | DOI:10.1007/s12325-023-02634-7
Source: Adv Data - September 15, 2023 Category: Epidemiology Authors: Neal D Shore Bryan A Mehlhaff Michael S Cookson Daniel R Saltzstein Ronald Tutrone Bruce Brown Sophia Lu Mark Fallick Sarah Hanson Fred Saad Source Type: research
Fabrication and Assessment of Orodispersible Tablets Loaded with Cubosomes for the Improved Anticancer Activity of Simvastatin against the MDA-MB-231 Breast Cancer Cell Line
Polymers (Basel). 2023 Apr 2;15(7):1774. doi: 10.3390/polym15071774.ABSTRACTVarious factors limit the use of simvastatin as an anticancer drug. Therefore, this study aimed to analyse simvastatin (SIM)-loaded cubosome efficacy against breast cancer. SIM-loaded cubosomes were prepared using the emulsification method using different glyceryl monooleate, Pluronic F127 (PF-127), and polyvinyl alcohol (PVA) ratios. The best cubosomal formula was subjected to an in vitro cytotoxicity analysis using the human breast cancer cell line, MDA-MB-231 (MDA) (ATCC, HTB-26), and formulated as oral disintegrating tablets through direct comp...
Source: Cancer Control - April 13, 2023 Category: Cancer & Oncology Authors: Randa Mohammed Zaki Amal El Sayeh Abou El Ela Alanood S Almurshedi Basmah Nasser Aldosari Abdullah A Aldossari Mohamed A Ibrahim Source Type: research
Engineered Microencapsulated Lactoferrin Nanoconjugates for Oral Targeted Treatment of Colon Cancer
This study provides the proof of concept for using NIMDs to enhance the effect of protein NPs in CRC treatment.PMID:37039769 | DOI:10.1021/acs.biomac.3c00037
Source: Biomacromolecules - April 11, 2023 Category: Biochemistry Authors: Yomna M Elmorshedy Mohamed Teleb Marwa A Sallam Kadria A Elkhodairy Mohammed Bahey-El-Din Doaa A Ghareeb Shaymaa A Abdulmalek Shimaa A H Abdel Monaim Adnan A Bekhit Ahmed O Elzoghby Fernando Albericio Sherine N Khattab Source Type: research
Fight Aging! Newsletter, March 20th 2023
This study also provides the potential for de novo generation of complex organs in vivo.
T Cells May Play a Role in the Brain Inflammation Characteristic of Neurodegenerative Conditions
https://www.fightaging.org/archives/2023/03/t-cells-may-play-a-role-in-the-brain-inflammation-characteristic-of-neurodegenerative-conditions/
Alzheimer's disease, and other forms of neurodegenerative condition, are characterized by chronic inflammation in brain tissue. Unresolved inflammatory signaling is disruptive of tissue structure and function. Here, researchers provide evidence for T cells to become involved in this...
Source: Fight Aging! - March 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Organic anion-transporting polypeptide 2B1 knockout and humanized mice; insights into the handling of bilirubin and drugs
Pharmacol Res. 2023 Mar 10:106724. doi: 10.1016/j.phrs.2023.106724. Online ahead of print.ABSTRACTOrganic anion transporting polypeptide 2B1 (OATP2B1/SLCO2B1) facilitates uptake transport of structurally diverse endogenous and exogenous compounds. To investigate the roles of OATP2B1 in physiology and pharmacology, we established and characterized Oatp2b1 knockout (single Slco2b1-/- and combination Slco1a/1b/2b1-/-) and humanized hepatic and intestinal OATP2B1 transgenic mouse models. While viable and fertile, these strains exhibited a modestly increased body weight. In males, unconjugated bilirubin levels were markedly red...
Source: Cancer Control - March 12, 2023 Category: Cancer & Oncology Authors: Wenlong Li Dilek Iusuf Rolf W Sparidans Els Wagenaar Yaogeng Wang Dirk R de Waart Margarida L F Martins St éphanie van Hoppe Maria C Lebre Olaf van Tellingen Jos H Beijnen Alfred H Schinkel Source Type: research
The Association of Metformin, Other Antidiabetic Medications, and Statins With the Prognosis of Colon Cancer in Patients With Type 2 Diabetes: A Retrospective Cohort Study
CONCLUSION: Additional evidence was found for use of statins being associated with an improved survival from CC in patients with pre-existing T2D, but for metformin use the evidence was weaker.PMID:36422298 | DOI:10.1177/10732748221134090
Source: Cancer Control - November 24, 2022 Category: Cancer & Oncology Authors: Sami Erkinantti Ari Hautakoski Reijo Sund Martti Arffman Elina Urpilainen Ulla Puistola Arja Jukkola Karihtala Peeter Esa L äärä Source Type: research
Effect of concomitant use of pitavastatin with neoadjuvant chemotherapy protocols in breast cancer patients: A randomized controlled clinical trial
CONCLUSION: Concomitant use of pitavastatin with standard neoadjuvant chemotherapy protocols may improve neoadjuvant chemotherapy responses in patients with breast cancer.PMID:36387337 | PMC:PMC9649354 | DOI:10.1016/j.jsps.2022.07.011
Source: Cancer Control - November 17, 2022 Category: Cancer & Oncology Authors: Samar A Dewidar Omar Hamdy Ahmed Eltantawy Mohamed El-Mesery Amal M El Gayar Moetaza M Soliman Source Type: research
Genome-wide profiling of dysregulated piRNAs and their target genes implicated in oncogenicity of Tongue Squamous Cell Carcinoma
This study provides the first evidence of the piRNome of TSCC, which could be investigated further to decode piRNA-mediated gene regulations in malignancy and potential drug targets, such as FDFT1.PMID:36179965 | DOI:10.1016/j.gene.2022.146919
Source: Gene - September 30, 2022 Category: Genetics & Stem Cells Authors: Trisha Chattopadhyay Pooja Gupta Rojalin Nayak Bibekanand Mallick Source Type: research
Fight Aging! Newsletter, August 8th 2022
In conclusion, aging research will benefit from a better definition of how specific regulators map onto age-dependent change, considered on a phenotype-by-phenotype basis. Resolving some of these key questions will shed more light on how tractable (or intractable) the biology of aging is.
Does Acarbose Extend Life in Short Lived Species via Gut Microbiome Changes?
https://www.fightaging.org/archives/2022/08/does-acarbose-extend-life-in-short-lived-species-via-gut-microbiome-changes/
Acarbose is one of a few diabetes medications shown to modestly slow aging in short-lived species. Researchers here take a ...
Source: Fight Aging! - August 7, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Risks of metabolic diseases and androgen deprivation therapy for prostate cancer in a Chinese population: a prospective multi-centre cohort study
CONCLUSION: Chinese receiving ADT are exposed to increased risks of new-onset hypertension, diabetes and hyper-lipidaemia, and a higher likelihood of stepping up pharmaceutical control for pre-existing comorbidities. This highlights physicians' role to monitor metabolic profiles in at-risk men upon offering ADT.PMID:35217907 | DOI:10.1007/s11255-022-03151-2
Source: Cancer Control - February 26, 2022 Category: Cancer & Oncology Authors: Chris Wong Peggy Chu Jeremy Teoh Peter Chiu C H Yee Lysander Chau Marco Chan Helen Wan Steven Leung C F Ng Source Type: research
Fight Aging! Newsletter, November 8th 2021
In conclusion, in less common and visible cardiovascular diseases, it is crucial to recognize substantial progress and achievement, given that penetration of such information into clinical practice and the patient community can be inconsistent. Diseases such as hypertrophic cardiomyopathy, pulmonary arterial hypertension, and ATTR cardiac amyloidosis, once linked to a uniformly adverse prognosis, are now associated with the opportunity for patients to experience satisfactory quality of life and extended longevity.
VitaDAO, a Novel Approach to Crowdfunding Life Science Research
https://www.fightaging.org/archive...
Source: Fight Aging! - November 7, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cholesterol-lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity
CONCLUSIONS: Lowering serum cholesterol decreased signaling through mTORC2 and enhance antitumor CD8+ T cell memory. We provide a rationale for large-scale clinical testing of cholesterol lowering strategies for prostate cancer chemoprevention.PMID:34728526 | DOI:10.1158/1078-0432.CCR-21-1535
Source: Cell Research - November 3, 2021 Category: Cytology Authors: Yanping Wang Sungyong You Shengchen Su Austin Yeon Eric M Lo Sungjin Kim James L Mohler Michael R Freeman Hyung L Kim Source Type: research
