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Cancer: Oral Cancer
Drug: Acetylcysteine
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Total 16 results found since Jan 2013.
Targeted Knockdown of Macrophage Migration Inhibitory Factor Enhances UVB Irradiation-Induced Apoptosis Via Increasing ROS Generation in Oral Squamous Cell Carcinoma
Conclusion: MIF knockdown combined with UVB irradiation significantly inhibited the proliferation of OSCC cells. MIF was involved in UVB-induced ROS generation and enhanced UVB irradiation-induced mitochondria-dependent apoptosis of OSCC cells by activating the MAPK pathway. This suggests that MIF-targeted therapy combined with UVB irradiation may be a novel approach for treating OSCC.PMID:37272017 | DOI:10.1177/15330338231163436
Source: Cancer Control - June 5, 2023 Category: Cancer & Oncology Authors: Tian Chen Qibing Chen Fen Li Manli Zeng Bingru Wang Shiyong Huang Shiming Chen Zezhang Tao Source Type: research
Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS
CONCLUSIONS: Melatonin combined with erastin exhibits synergistic anticancer effects without adverse reactions. Herein, this combination might become a promising alternative strategy for oral cancer treatment.PMID:37131152 | PMC:PMC10155313 | DOI:10.1186/s11658-023-00449-6
Source: Mol Biol Cell - May 2, 2023 Category: Molecular Biology Authors: Leilei Wang Chuan Wang Xuan Li Zhuoying Tao Wangyong Zhu Yuxiong Su Wing Shan Choi Source Type: research
Fight Aging! Newsletter, December 26th 2022
This article on senolytic therapies to selectively remove senescent cells in old tissues is in part a matter of Unity Biotechnology talking up their position. The company suffered from first mover disadvantage in bringing senolytic drugs into clinical development. The field has made progress very rapidly over the last decade, and startups founded even just a couple of years after Unity's launch benefited from greater knowledge and a selection of better technologies to work with. Still, one can be talking up one's position and also be right. The accumulation of senescent cells is profoundly harmful, a significant contributi...
Source: Fight Aging! - December 25, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Protective effects of resveratrol against 5-fluorouracil-induced oxidative stress and inflammatory responses in human keratinocytes
In this study, we examined the protective effects of resveratrol on 5-FU-induced oxidative stress and inflammatory responses in normal human keratinocytes (HaCaT cell) as in vitro oral mucositis model. HaCaT cells were exposed to 5-FU and simultaneously treated with resveratrol. The effects of resveratrol on 5-FU-induced cytotoxicity were evaluated using cell viability assay. The production of reactive oxygen species (ROS) was measured using a fluorescence spectrophotometer. The effects of resveratrol on nuclear factor erythroid 2-related factor 2 (Nrf2), silent information regulator transcript-1 (SIRT-1), and nuclear fact...
Source: Clinical Biochemistry - December 3, 2021 Category: Biochemistry Authors: Shu Chen Naofumi Tamaki Yasusei Kudo Takaaki Tsunematsu Kaname Miki Naozumi Ishimaru Hiro-O Ito Source Type: research
Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling
In this study, we aimed to investigate the potential anti-proliferative and pro-apoptotic activities of SNG in a panel of MM cell lines (U266, IM9, MM1S, and RPMI-8226). SNG treatment of MM cells resulted in a dose-dependent decrease in cell viability through mitochondrial membrane potential loss and activation of caspase 3, 9, and cleavage of PARP. Pre-treatment of MM cells with a universal caspase inhibitor, Z-VAD-FMK, prevented SNG mediated loss of cell viability, apoptosis, and caspase activation, confirming that SNG-mediated apoptosis is caspase-dependent. The SNG-mediated apoptosis appears to be resulted from suppres...
Source: Frontiers in Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research
Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants
Conclusion: The present study suggests the involvement of both oxidative and other mechanisms in paclitaxel-induced neurotoxicity.
Source: In Vivo - June 23, 2018 Category: Research Authors: HARA, Y., SAKAGAMI, H., SHI, H., ABE, T., TAMURA, N., TAKESHIMA, H., HORIE, N., KANEKO, T., SHIRATSUCHI, H., KANEKO, T. Tags: Experimental Studies Source Type: research
The orally active pterocarpanquinone LQB ‐118 exhibits cytotoxicity in prostate cancer cell and tumor models through cellular redox stress
ConclusionLQB‐118 is a developing and orally active pterocarpanquinone agent that effectively kills PCa cells through quinone reduction and ROS generation. The inhibition SOD1 expression enhances LQB‐118 activity, presumably by impairing the cellular antioxidant response.
Source: The Prostate - November 6, 2017 Category: Urology & Nephrology Authors: Thiago Martino, Tarana A. Kudrolli, Binod Kumar, Isis Salviano, Andr é Mencalha, Marsen Garcia P. Coelho, Graça Justo, Paulo R. Ribeiro Costa, Kátia C. Carvalho Sabino, Shawn E. Lupold Tags: ORIGINAL ARTICLE Source Type: research
