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The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids
Conclusion In Table 1, an overview is presented of the complex roles of AAs described in this review regarding the microbiome-gut-immune-brain axis in ASD. Besides behavioral deficits, people with ASD are characterized by systemic inflammation, gastrointestinal immune-related disturbances and changes in the gut microbiota composition. Moreover, differences in levels of specific AAs in various body compartments, including the intestinal tract, blood, urine and brain have been reported in patients with ASD, as well as in rodent models for ASD. This review described that specific AAs can modulate the intestinal epithelial im...
Source: Frontiers in Endocrinology - April 15, 2019 Category: Endocrinology Source Type: research

Spring health cheat sheet
As the spring weather approaches, many common winter infections recede. However, warmer temperatures can introduce a new set of health challenges. As trees and flowers bloom and grass grows, susceptible children will start to display symptoms of seasonal allergies, triggering flares of asthma and eczema. And, As children spend more time outdoors, parents also need to watch for exposure to ticks, poison ivy and excess sun. Here are a few tips to keeping your child healthy this spring. Seasonal allergies: What can you do? During allergy season: have your child bathe after spending time outdoors to remove allergens fro...
Source: Thrive, Children's Hospital Boston - April 7, 2017 Category: Pediatrics Authors: Carolyn Sax Tags: Health & Wellness Parenting allergies asthma Carolyn Sax conjunctivitis lyme disease sunburn Source Type: news

Effect of curcumin on nasal symptoms and airflow in patients with perennial allergic rhinitis.
CONCLUSION: This pilot study provides the first evidence of the capability of curcumin of improving nasal airflow and modulating immune response in patients with AR. PMID: 27789120 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - October 23, 2016 Category: Allergy & Immunology Authors: Wu S, Xiao D Tags: Ann Allergy Asthma Immunol Source Type: research

Spring health cheat sheet
The beginning of spring often brings warm weather and hours of outdoor fun, and many common winter infections recede. Unfortunately, spring weather can bring its own health challenges. As soon as the trees and flowers bloom, flowers bud and the grass grows, susceptible children will start to display symptoms of seasonal allergies. Seasonal allergies cause sneezing, runny nose and itchy red eyes and can trigger flares of asthma and eczema. As children spend more time outdoors, parents also need to watch for exposure to ticks, poison ivy and excess sun. Read on for the parents’ guide to spring health. Seasonal allergies: ...
Source: Thrive, Children's Hospital Boston - March 29, 2016 Category: Pediatrics Authors: Carolyn Sax Tags: Health & Wellness Parenting allergies asthma Carolyn Sax conjunctivitis lyme disease poion ivy sunburn Source Type: news

ARRY-502, a potent, selective, oral CRTh2 antagonist reduces Th2 mediators in patients with mild to moderate Th2-driven asthma
Asthma and other allergic diseases are associated with mast cell activation and prostaglandin D2 (PGD2) generation. PGD2 exerts pro-inflammatory activity via chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2). The safety and efficacy of CRTh2 antagonist ARRY-502 was studied in mild atopic asthmatic adults in a double-blind, placebo-controlled 4 week phase 2a study. Enrolled patients were free of inhaled corticosteroids with an FEV1% predicted of 60-85%. Potential participants were screened and randomized to receive 200 mg BID ARRY-502 (n = 93) or matching placebo (n = 91). In patients with elevated...
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Wenzel, S., Chantry, D., Eberhardt, C., Hopkins, R., Saunders, M., Anderson, L., Aitchinson, R., Bell, S., Izuhara, K., Ono, J., Burgess, L. Tags: 5.3 Allergy and Immunology Source Type: research

North Texas Fracking Zone Sees Growing Health Worries
This story was published by The Center for Public Integrity, a nonprofit, nonpartisan investigative news organization in Washington, D.C. DALLAS—Propped up on a hospital bed, Taylor Ishee listened as his mother shared a conviction that choked her up. His rare cancer had a cause, she believes, and it wasn’t genetics. Others in Texas have drawn the same conclusions about their confounding illnesses. Jana DeGrand, who suffered a heart attack and needed both her gallbladder and her appendix removed. Rebecca Williams, fighting off unexplained rashes, sharp headaches and repeated bouts of pneumonia. Maile Bush, who needed ...
Source: Science - The Huffington Post - December 11, 2014 Category: Science Source Type: news