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Cancer: Liver Cancer
Drug: Fortamet
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Total 75 results found since Jan 2013.
Metformin promotes ferroptosis and sensitivity to sorafenib in hepatocellular carcinoma cells via ATF4/STAT3
CONCLUSION: Metformin promotes ferroptosis and sensitivity to sorafenib in hepatocellular carcinoma cells via ATF4/STAT3, and it inhibits HCC progression.PMID:37326750 | DOI:10.1007/s11033-023-08492-4
Source: Mol Biol Cell - June 16, 2023 Category: Molecular Biology Authors: Zongqiang Hu Yingpeng Zhao Laibang Li Jie Jiang Wang Li Yuanyi Mang Yang Gao Yun Dong Jiashun Zhu Chaomin Yang Jianghua Ran Li Li Shengning Zhang Source Type: research
Delivering Relaxin Plasmid by Polymeric Metformin Lipid Nanoparticles for Liver Fibrosis Treatment
CONCLUSION: This research proposed a novel non-toxic treatment method for liver fibrosis with a nano-system to effectively treat liver fibrosis.PMID:37032506 | DOI:10.2174/1567201820666230407135026
Source: Current Drug Delivery - April 10, 2023 Category: Drugs & Pharmacology Authors: Yujie Li Lisha Ma Yang Xiong Jingbin Shi Feifeng Zhang Qian Chai Gengshan Hu Yun Liu Source Type: research
Metformin Suppresses Hepatocellular Carcinoma through Regulating Alternative Splicing of LGR4
CONCLUSIONS: LGR4 could promote the ability of cell proliferation, migration, and invasion in HCC, which could be reduced by metformin through alternative splicing.PMID:36385965 | PMC:PMC9652085 | DOI:10.1155/2022/1774095
Source: Journal of Oncology - November 17, 2022 Category: Cancer & Oncology Authors: Han Zhuo Shuying Miao Zhenquan Jin Deming Zhu Zhenggang Xu Dongwei Sun Jie Ji Zhongming Tan Source Type: research
Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis
EMBO Mol Med. 2022 Nov 2:e16082. doi: 10.15252/emmm.202216082. Online ahead of print.ABSTRACTMetformin, a well-known antidiabetic drug, has been repurposed for cancer treatment; however, recently observed drug resistance and tumor metastasis have questioned its further application. Here, we found that long-term metformin exposure led to metabolic adaptation of hepatocellular carcinoma (HCC) cells, which was characterized by an obvious epithelial-mesenchymal transition (EMT) phenotype and compensatory elevation of oxidative phosphorylation (OXPHOS). TOMM34, a translocase of the outer mitochondrial membrane, was upregulated ...
Source: Molecular Medicine - November 2, 2022 Category: Molecular Biology Authors: Ping Jin Jingwen Jiang Li Zhou Zhao Huang Siyuan Qin Hai-Ning Chen Liyuan Peng Zhe Zhang Bowen Li Maochao Luo Tingting Zhang Hui Ming Ning Ding Lei Li Na Xie Wei Gao Wei Zhang Edouard C Nice Yuquan Wei Canhua Huang Source Type: research
ANGPTL8 accelerates liver fibrosis mediated by HFD-induced inflammatory activity via LILRB2/ERK signaling pathways
CONCLUSIONS: Our data support that ANGPTL8 is a proinflammatory factor that accelerates NAFLD-associated liver fibrosis induced by HFD. The serum ANGPTL8 level may be a potential and specific diagnostic marker for liver fibrosis, and targeting ANGPTL8 holds great promise for developing innovative therapies to treat NAFLD-associated liver fibrosis.PMID:36031141 | DOI:10.1016/j.jare.2022.08.006
Source: Adv Data - August 28, 2022 Category: Epidemiology Authors: Zongli Zhang Yue Yuan Lin Hu Jian Tang Zhongji Meng Longjun Dai Yujiu Gao Shinan Ma Xiaoli Wang Yahong Yuan Qiufang Zhang Weibin Cai Xuzhi Ruan Xingrong Guo Source Type: research
Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research
