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Cancer: Oropharyngeal Cancer
Vaccination: Cancer Vaccines
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Total 235 results found since Jan 2013.
Full eradication of pre-clinical human papilloma virus-induced tumors by a lentiviral vaccine
EMBO Mol Med. 2023 Sep 7:e17723. doi: 10.15252/emmm.202317723. Online ahead of print.ABSTRACTHuman papillomavirus (HPV) infections are the cause of all cervical and numerous oropharyngeal and anogenital cancers. The currently available HPV vaccines, which induce neutralizing antibodies, have no therapeutic effect on established tumors. Here, we developed an immuno-oncotherapy against HPV-induced tumors based on a non-integrative lentiviral vector encoding detoxified forms of the Early E6 and E7 oncoproteins of HPV16 and 18 genotypes, namely, "Lenti-HPV-07". A single intramuscular injection of Lenti-HPV-07 into mice bearing...
Source: Molecular Medicine - September 7, 2023 Category: Molecular Biology Authors: La ëtitia Douguet Ingrid Fert Jodie Lopez Benjamin Vesin Fabien Le Chevalier Fanny Moncoq Pierre Authi é Trang-My Nguyen Amandine Noirat Fabien N évo Catherine Blanc Maryline Bourgine David Hardy Fran çois Anna Laleh Majlessi Pierre Charneau Source Type: research
Applying the COM-B behaviour model to understand factors which impact school immunisation nurses' attitudes towards designing and delivering a HPV educational intervention in post-primary schools for 15-17 year old students in Northern Ireland, UK
CONCLUSION: IMNs feel that they are the most appropriate professionals to design/deliver HPV education for 15-17 year old students. National policy change, based on collaboration between the Public Health Agency and Education Authority, is a key factor in facilitating IMNs to implement this school-based HPV education intervention.PMID:37543445 | DOI:10.1016/j.vaccine.2023.07.066
Source: Vaccine - August 5, 2023 Category: Allergy & Immunology Authors: Terri Flood Marian McLaughlin Ciara M Hughes Iseult M Wilson Source Type: research
The Clinical Utility of Circulating HPV DNA Biomarker in Oropharyngeal, Cervical, Anal, and Skin HPV-Related Cancers: A Review
Pathogens. 2023 Jul 5;12(7):908. doi: 10.3390/pathogens12070908.ABSTRACTHuman papillomavirus (HPV) is recognized as being related to a wide variety of known cancers: cervical, oropharyngeal, anal, vaginal, penile, and skin. For some of these cancers, rigorous algorithms for screening, therapeutical interventions, and follow-up procedures have been established. Vaccination using the nonvalent anti-HPV vaccine, which prevents infection regarding the most frequently involved high-risk HPV types (16, 18, 31, 33, 45, 52, and 58) and low-risk HPV types (6 and 11), has also extensively prevented, controlled, and even eradicated H...
Source: Cancer Control - July 29, 2023 Category: Cancer & Oncology Authors: Ioana Maria Andrioaie Ionut Luchian Costin D ămian Giorgio Nichitean Elena Porumb Andrese Theodor Florin Pantilimonescu Bogdan Trandab ăț Liviu Jany Prisacariu Dana Gabriela Budal ă Daniela Cristina Dimitriu Luminita Smaranda Iancu Ramona Gabriela Urs Source Type: research
Oral HPV Infection in Women with HPV-Positive Cervix Is Closely Related to Oral Sex
Diagnostics (Basel). 2023 Jun 16;13(12):2096. doi: 10.3390/diagnostics13122096.ABSTRACTThe oral transmission of HPV and, consequently, the risk of oral cancer has increased in the last years. Oral sex has often been implicated among the risk factors for oral HPV infections, however, there is still no consensus on these topics, nor on the relationship between genital and oral HPV infections. The present study aimed to evaluate the coexistence of papilloma virus, at the levels of the oral and genital mucosa, in women with a histologically confirmed HPV lesions (and a positive HPV test) at the genital level and a negative HPV...
Source: Herpes - June 28, 2023 Category: Infectious Diseases Authors: Maria Teresa Bruno Sara Boemi Giuseppe Caruso Francesco Sgalambro Salvatore Ferlito Antonio Cavallaro Maria Chiara Sudano Marco Palumbo Source Type: research
Prevalence and distribution of high-risk Human Papillomavirus in Western T ürkiye between 2019 and 2022
This study indicates the need for higher coverage of HPV vaccination in Western Türkiye.PMID:37347660 | DOI:10.1556/030.2023.02066
Source: Acta Microbiologica et Immunologica Hungarica - June 22, 2023 Category: Microbiology Authors: G ülfem Terek Ece Do ğukan Pira G ökçe Lara Bodur Source Type: research
Cross-neutralizing protection of vaginal and oral mucosa from HPV challenge by vaccination in a mouse model
Vaccine. 2023 Jun 1:S0264-410X(23)00618-7. doi: 10.1016/j.vaccine.2023.05.057. Online ahead of print.ABSTRACTThe species and tissue specificities of HPV (human papillomavirus) for human infection and disease complicates the process of prophylactic vaccine development in animal models. HPV pseudoviruses (PsV) that carry only a reporter plasmid have been utilized in vivo to demonstrate cell internalization in mouse mucosal epithelium. The current study sought to expand the application of this HPV PsV challenge model with both oral and vaginal inoculation and to demonstrate its utility for testing vaccine-mediated dual-site i...
Source: Vaccine - June 3, 2023 Category: Allergy & Immunology Authors: Chelsea Sanders Rebecca L Matthews Sayyed Hamid Zarkesh Esfahani Nazneen Khan Nimit L Patel Joseph D Kalen Reinhard Kirnbauer Richard B Roden Simone Difilippantonio Ligia A Pinto Robert H Shoemaker Jason D Marshall Source Type: research
Etiology, diagnosis, treatment, and prevention of human papilloma virus-associated oropharyngeal squamous cell carcinoma
Int J Clin Oncol. 2023 Apr 24. doi: 10.1007/s10147-023-02336-8. Online ahead of print.ABSTRACTClassical oropharyngeal squamous cell carcinoma (OPSCC) caused by alcohol consumption and smoking and HPV-associated OPSCC caused by human papillomavirus (HPV) infection have different etiologies, incidences, and prognoses. Therefore, the 8th American Joint committee on Cancer (AJCC) and Union for International Cancer Control (UICC) TNM classifications propose distinguishing HPV-associated OPSCC from classical OPSCC and classifying it as an independent disease. Therefore, this review provides an overview of HPV-associated OPSCC fr...
Source: Cancer Control - April 24, 2023 Category: Cancer & Oncology Authors: Hirotaka Shinomiya Ken-Ichi Nibu Source Type: research
Therapeutic efficacy of a VSV-GP-based human papilloma virus vaccine in a murine cancer model
In this study, we generated a live attenuated cancer vaccine based on the chimeric vesicular stomatitis virus VSV-GP, which has previously proven to be a potent vaccine vector and oncolytic virus. Genes at an earlier position in the genome more to the 3' end are expressed stronger compared to genes located further downstream. By inserting an HPV16-derived antigen cassette consisting of E2, E6 and E7 into VSV-GP either at first (HPVp1) or fifth (HPVp5) position in VSV-GP's genome we aimed to analyze the effect of vaccine antigen position and consequently expression level on viral fitness, immunogenicity, and anti-tumoral ef...
Source: Mol Biol Cell - April 22, 2023 Category: Molecular Biology Authors: Lydia Riepler Laura-Sophie Frommelt Sarah Wilmschen-Tober Wilbert Mbuya Kathrin Held Andr é Volland Dorothee von Laer Christof Geldmacher Janine Kimpel Source Type: research
Risk Factors and Trends for HPV-Associated Subsequent Malignant Neoplasms among Adolescent and Young Adult Cancer Survivors
CONCLUSIONS: HPV-SMN in AYA survivors are driven by oropharyngeal cancers despite temporal declines in oropharyngeal-SMN. Hispanic survivors are at risk for cervical-SMN relative to the general population.IMPACT: Encouraging HPV vaccination and cervical and oral cancer screenings may reduce HPV-SMN burden among AYA survivors.PMID:37071501 | DOI:10.1158/1055-9965.EPI-22-0826
Source: Cancer Control - April 18, 2023 Category: Cancer & Oncology Authors: Judy Y Ou Natalie Bennion Kellee Parker Douglas Fair Heidi A Hanson Deanna Kepka Echo L Warner Joemy M Ramsay Heydon K Kaddas Anne C Kirchhoff Source Type: research
