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Specialty: Cancer & Oncology
Cancer: Bone Cancers
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Total 114 results found since Jan 2013.
Posttranscriptional inhibition of γ-adducin promotes the proliferation and migration of osteosarcoma cells
CONCLUSIONS: Our study found that ADD3 functioned as a tumor suppressor gene during osteosarcoma development. The abnormal upregulation of miR-23b-3p targeted the expression of ADD3 and resulted in accelerated osteosarcoma cell proliferation and migration. Thus, the miR-23b-3p/ADD3 axis contributes to the development of osteosarcoma and ADD3 is a key driver of malignancy.PMID:34632867 | DOI:10.1177/03008916211050687
Source: Tumori - October 11, 2021 Category: Cancer & Oncology Authors: Zhigang Suo Xiucai Ma Yueping Ding Yu Zhou Xiangguo Duan Le Fei Jianmin Song Huiqiang Ding Source Type: research
Knockdown of lncRNA C5orf66-AS1 inhibits osteosarcoma cell proliferation and invasion via miR-149-5p upregulation
Oncol Lett. 2021 Nov;22(5):757. doi: 10.3892/ol.2021.13018. Epub 2021 Sep 2.ABSTRACTOsteosarcoma (OS) is the most common primary malignant bone tumor in the pediatric age group. Despite the various potential treatments for OS, the cure rate of patients with OS remains very low. An increasing number of long non-coding RNAs (lncRNAs) have been identified as key regulators of the progression of malignant human tumors. However, the biological functions of the lncRNA C5orf66-antisense 1 (C5orf66-AS1) in OS are yet to be fully elucidated. The present study aimed to investigate the functions and underlying mechanisms of C5orf66-A...
Source: Oncology Letters - September 20, 2021 Category: Cancer & Oncology Authors: Hui Zhang Jie Song Source Type: research
Cancers, Vol. 13, Pages 3201: Serine-Threonine Kinase Receptor-Associated Protein (STRAP) Knockout Decreases the Malignant Phenotype in Neuroblastoma Cell Lines
Conclusion: These novel findings demonstrated that STRAP plays a role in tumorigenesis and maintenance of neuroblastoma stemness.
Source: Cancers - June 26, 2021 Category: Cancer & Oncology Authors: Laura V Bownes Adele P Williams Raoud Marayati Colin H Quinn Sara C Hutchins Jerry E Stewart Trung Vu Juliet L Easlick Elizabeth Mroczek-Musulman David K Crossman Joshua C Anderson Christopher D Willey Pran K Datta Elizabeth A Beierle Tags: Article Source Type: research
Oncolytic virotherapy reverses chemoresistance in osteosarcoma by suppressing MDR1 expression
ConclusionOur results suggest that MDR1 is an attractive therapeutic target for chemoresistant OS. Tumor-specific virotherapy is thus a promising strategy for reversing chemoresistance in OS patients via suppression of MDR1 expression.
Source: Cancer Chemotherapy and Pharmacology - June 10, 2021 Category: Cancer & Oncology Source Type: research
Knockdown of 91 H Suppresses the Tumorigenesis of Osteosarcoma via Inducing Methylation of CDK4 Promoter
CONCLUSION: knockdown of 91 H suppressed the tumorigenesis of osteosarcoma via inducing methylation of CDK4 promoter in vitro and in vivo. Thus, 91 H may serve as a new target for the treatment of osteosarcoma.PMID:33499776 | PMC:PMC7844445 | DOI:10.1177/1533033821990006
Source: Technology in Cancer Research and Treatment - January 27, 2021 Category: Cancer & Oncology Authors: Suoli Cheng Jianping Zheng Xueqin Liu Jiandang Shi Fan Gong Xu Zhang Changhao Liu Cuiyun Liu Source Type: research
Knockdown of 91 H Suppresses the Tumorigenesis of Osteosarcoma via Inducing Methylation of CDK4 Promoter.
CONCLUSION: knockdown of 91 H suppressed the tumorigenesis of osteosarcoma via inducing methylation of CDK4 promoter in vitro and in vivo. Thus, 91 H may serve as a new target for the treatment of osteosarcoma.
PMID: 33499776 [PubMed - in process]
Source: Technology in Cancer Research and Treatment - January 1, 2021 Category: Cancer & Oncology Authors: Cheng S, Zheng J, Liu X, Shi J, Gong F, Zhang X, Liu C, Liu C Tags: Technol Cancer Res Treat Source Type: research
Cancers, Vol. 12, Pages 3781: Novel Thiosemicarbazones Sensitize Pediatric Solid Tumor Cell-Types to Conventional Chemotherapeutics through Multiple Molecular Mechanisms
We examined the effects of combining the novel thiosemicarbazones, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), or its analog, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), with the standard chemotherapies, celecoxib (CX), etoposide (ETO), or temozolomide (TMZ). These combinations were analyzed for synergism to inhibit proliferation of three pediatric tumor cell-types, namely osteosarcoma (Saos-2), medulloblastoma (Daoy) and neuroblastoma (SH-SY5Y). In terms of mechanistic dissection, this study discovered novel thiosemicarbazone targets not previously identified and which are importa...
Source: Cancers - December 15, 2020 Category: Cancer & Oncology Authors: Silvia Paukovcekova Jan Skoda Jakub Neradil Erika Mikulenkova Petr Chlapek Jaroslav Sterba Des R. Richardson Renata Veselska Tags: Article Source Type: research
Downregulation of CDC20 suppressed cell proliferation, induced apoptosis, triggered cell cycle arrest in osteosarcoma cells, and enhanced chemosensitivity to cisplatin.
In this study, we aim to explore the role of CDC20 in two independent human OS cell lines' biological phenotype and chemotherapy sensitivity. We applied multiple approaches to measure cell growth, cell cycle, and apoptosis with or without deregulation or overexpression of CDC20. We found that the downregulation of CDC20 by siRNA or apcin suppressed cell proliferation, induced apoptosis, and triggered cell cycle arrest. Consistently, overexpression of CDC20 in normal cells promoted cell growth, inhibited apoptosis. What's more, the additional treatment of siCDC20 or apcin achieved better anticancer effects than that of cisp...
Source: Neoplasma - October 30, 2020 Category: Cancer & Oncology Authors: Gao Y, Guo C, Fu S, Cheng Y, Song C Tags: Neoplasma Source Type: research
