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Cancer: Epithelial Cancer
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Fascin in migration and metastasis of breast cancer cells - A review
Adv Med Sci. 2023 Sep 1;68(2):290-297. doi: 10.1016/j.advms.2023.08.003. Online ahead of print.ABSTRACTCancer cell migration and metastasis are the biggest problems in the treatment of cancer patients. The most aggressive breast cancer (BC) is the triple-negative type. Therefore, effective therapeutic targets that limit cell migration are sought. One such target may be fascin, as its overexpression is characteristic to triple-negative breast cancer. The high level of fascin enables the formation of protrusion and thus promotes the invasion of cancer cells. Fascin also shows co-localization or functional relationships with ...
Source: Advances in Medical Sciences - September 3, 2023 Category: Biomedical Science Authors: Magdalena Izdebska Wioletta Zieli ńska Adrian Krajewski Alina Grzanka Source Type: research
Mechanisms Of Breast Cancer Progression Induced BY Environment-Polluting ARYL Hydrocarbon Receptor Agonists
The objectives of this review are a) to summarize recent original experimental, preclinical, and clinical studies on the biological mechanisms of AhR agonists which interfere with the regulation of breast endocrine functions, and b) to examine the biological effects of AhR ligands and their impact on breast cancer development and progression. We discuss biological mechanisms of action in cell viability, cell cycle, proliferation, epigenetic changes, epithelial to mesenchymal transition, and cell migration and invasion. In addition, we examine the effects of AhR ligands on angiogenic processes, metastasis, chemoresistance, ...
Source: Biochemical Pharmacology - September 2, 2023 Category: Drugs & Pharmacology Authors: Noelia V Miret Carolina A Pontillo Sol Buj án Florencia A Chiappini Andrea S Randi Source Type: research
Higher 13-Gene-Estimated TMB Detected from Plasma ctDNA is Associated with Worse Outcome for T-Cell Lymphoma Patients
Adv Biol (Weinh). 2023 Sep 1:e2300042. doi: 10.1002/adbi.202300042. Online ahead of print.ABSTRACTExome sequencing of in situ tumor samples reveals that mutated genes can predict the prognosis of patients with T-cell lymphoma (TCL). However, how tumor mutation burden (TMB) derived from circulating tumor DNA (ctDNA) may stratify TCL patients remains unclear.The plasma ctDNA of 79 newly diagnosed TCL patients from the clinical center is used for targeted exome sequencing, and the exome data of 4035 TCL patients from the Catalogue of Somatic Mutations in Cancer (COSMIC) database is obtained for comparison analysis.TCL patient...
Source: Adv Data - September 2, 2023 Category: Epidemiology Authors: Cunte Chen Ling Huang Zheng Chen Qiuxiang Ou Sichu Liu Xinmiao Jiang Feili Chen Xiaojuan Wei Hanguo Guo Yang Shao Chengwu Zeng Yangqiu Li Wenyu Li Source Type: research
ASO Visual Abstract: The 2022 PSOGI International Consensus on HIPEC Regimens for Peritoneal Malignancies: Epithelial Ovarian Cancer
Ann Surg Oncol. 2023 Sep 2. doi: 10.1245/s10434-023-14232-6. Online ahead of print.NO ABSTRACTPMID:37659975 | DOI:10.1245/s10434-023-14232-6
Source: Ann Oncol - September 2, 2023 Category: Cancer & Oncology Authors: Aditi Bhatt Olivier Glehen Oliver Zivanovic Donal Brennan Cedric Nadeau Willemien van Driel Naoual Bakrin Source Type: research
Higher 13-Gene-Estimated TMB Detected from Plasma ctDNA is Associated with Worse Outcome for T-Cell Lymphoma Patients
Adv Biol (Weinh). 2023 Sep 1:e2300042. doi: 10.1002/adbi.202300042. Online ahead of print.ABSTRACTExome sequencing of in situ tumor samples reveals that mutated genes can predict the prognosis of patients with T-cell lymphoma (TCL). However, how tumor mutation burden (TMB) derived from circulating tumor DNA (ctDNA) may stratify TCL patients remains unclear.The plasma ctDNA of 79 newly diagnosed TCL patients from the clinical center is used for targeted exome sequencing, and the exome data of 4035 TCL patients from the Catalogue of Somatic Mutations in Cancer (COSMIC) database is obtained for comparison analysis.TCL patient...
Source: Cancer Control - September 2, 2023 Category: Cancer & Oncology Authors: Cunte Chen Ling Huang Zheng Chen Qiuxiang Ou Sichu Liu Xinmiao Jiang Feili Chen Xiaojuan Wei Hanguo Guo Yang Shao Chengwu Zeng Yangqiu Li Wenyu Li Source Type: research
Mechanisms Of Breast Cancer Progression Induced BY Environment-Polluting ARYL Hydrocarbon Receptor Agonists
The objectives of this review are a) to summarize recent original experimental, preclinical, and clinical studies on the biological mechanisms of AhR agonists which interfere with the regulation of breast endocrine functions, and b) to examine the biological effects of AhR ligands and their impact on breast cancer development and progression. We discuss biological mechanisms of action in cell viability, cell cycle, proliferation, epigenetic changes, epithelial to mesenchymal transition, and cell migration and invasion. In addition, we examine the effects of AhR ligands on angiogenic processes, metastasis, chemoresistance, ...
Source: Biochemical Pharmacology - September 2, 2023 Category: Drugs & Pharmacology Authors: Noelia V Miret Carolina A Pontillo Sol Buj án Florencia A Chiappini Andrea S Randi Source Type: research
Epigenetic regulation of epithelial-mesenchymal transition during cancer development
Int Rev Cell Mol Biol. 2023;380:1-61. doi: 10.1016/bs.ircmb.2023.05.007. Epub 2023 Jun 13.ABSTRACTEpithelial-mesenchymal transition (EMT) plays essential roles in promoting malignant transformation of epithelial cells, leading to cancer progression and metastasis. During EMT-induced cancer development, a wide variety of genes are dramatically modified, especially down-regulation of epithelial-related genes and up-regulation of mesenchymal-related genes. Expression of other EMT-related genes is also modified during the carcinogenic process. Especially, epigenetic modifications are observed in the EMT-related genes, indicati...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Sunisa Yoodee Visith Thongboonkerd Source Type: research
Herbal melanin modulates PGE2 and IL-6 gastroprotective markers through COX-2 and TLR4 signaling in the gastric cancer cell line AGS
In conclusion, our results showed that HM enhances TLR4/COX-2-mediated secretion of gastroprotective markers PGE2 and IL-6, and upregulates mucin 4 gene expression in the human gastric epithelial cell line AGS, which may contribute to the promising beneficial gastroprotective effect of HM for human gastric prevention and treatment.PMID:37658354 | DOI:10.1186/s12906-023-04124-3
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Adila El-Obeid Yahya Maashi Rehab AlRoshody Ghada Alatar Modhi Aljudayi Hamad Al-Eidi Nouf AlGaith Altaf Husain Khan Adil Hassib Sabine Matou-Nasri Source Type: research
Epigenetic regulation of epithelial-mesenchymal transition during cancer development
Int Rev Cell Mol Biol. 2023;380:1-61. doi: 10.1016/bs.ircmb.2023.05.007. Epub 2023 Jun 13.ABSTRACTEpithelial-mesenchymal transition (EMT) plays essential roles in promoting malignant transformation of epithelial cells, leading to cancer progression and metastasis. During EMT-induced cancer development, a wide variety of genes are dramatically modified, especially down-regulation of epithelial-related genes and up-regulation of mesenchymal-related genes. Expression of other EMT-related genes is also modified during the carcinogenic process. Especially, epigenetic modifications are observed in the EMT-related genes, indicati...
Source: Mol Biol Cell - September 1, 2023 Category: Molecular Biology Authors: Sunisa Yoodee Visith Thongboonkerd Source Type: research
