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Total 145 results found since Jan 2013.

Altered Expression Levels of MicroRNA-155 and SOCS-1 in Peripheral Blood Mononuclear Cells of Newly Diagnosed Breast Cancer Patients
This study investigated the association of inflammatory changes with the variations of miR-155 expression in newly diagnosed breast cancer (NDBC) patients. Seventy NDBC patients were categorized as lobular and ductal subgroups and forty healthy individuals participated in this study. The expression rate of miR-155 and its downstream target gene, SOCS-1, as well as the plasma levels of IL-6, were evaluated in peripheral blood mononuclear cells of NDBC patients; using real-time PCR and enzyme-linked immunosorbent assay, respectively. Our results indicated an over-expression of miR-155 in the PBMCs of NDBC patients which was ...
Source: Iranian Journal of Allergy, Asthma and Immunology - May 7, 2022 Category: Allergy & Immunology Authors: Sara Iranparast Maryam Tahmasebi-Birgani Azim Motamedfar Afshin Amari Mehri Ghafourian Source Type: research

From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc
Conclusions and Perspectives In this review, we have discussed important milestones from the early description of “Serum-sickness” as being due to antibodies directed against Neu5Gc epitopes all the way to the present-day therapeutic implications of these antibodies in cancer therapy. Some of these milestones have been represented in a concise timeline (Figure 6). While the “Xenosialitis” hypothesis is well-supported in the human-like mouse models, it has yet to be conclusively proven in humans. It remains to be seen if “Xenosialitis” plays a role in other uniquely-human dis...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

Human, Nonhuman Primate, and Bat Cells Are Broadly Susceptible to Tibrovirus Particle Cell Entry
Discussion Tibroviruses are highly undercharacterized rhabdoviruses with unknown pathogenic potential. All isolated tibroviruses (BAV, BHV, CPV, SWBV, and TIBV) have only been found in biting midge vectors or in various, apparently healthy non-human mammals (Cybinski et al., 1980; Standfast et al., 1984; Cybinski and Gard, 1986; Gibbs et al., 1989). The discovery of BASV, EKV-1, and EKV-2 genomes in human sera (Grard et al., 2012; Stremlau et al., 2015) suggests that at least some tibroviruses could infect humans. Because BASV was discovered in the serum of a severely ill individual, tibroviruses should be considered pote...
Source: Frontiers in Microbiology - April 25, 2019 Category: Microbiology Source Type: research

Cancer stem cells markers CD44, CD24 and ALDH1 in breast cancer special histological types
Conclusions The expression distribution of breast CSC markers is largely dependent on histological type. Interestingly, within the distinct SHT, medullary and metaplastic carcinomas are the two types highly associated with high-grade carcinomas, basal-like and claudin-low molecular subtypes, and to the CSC phenotype CD44+/CD24–/low/ALDH1+.
Source: Journal of Clinical Pathology - February 21, 2013 Category: Pathology Authors: Beca, F. F. d., Caetano, P., Gerhard, R., Alvarenga, C. A., Gomes, M., Paredes, J., Schmitt, F. Tags: Immunology (including allergy), Breast cancer Original article Source Type: research

Adenocarcinoma of gallbladder: an immunohistochemical profile and comparison with cholangiocarcinoma
Conclusions Adenocarcinomas of gallbladder generally arise from a foregut cell lineage via a metaplasia-dysplasia-carcinoma sequence. A background of chronic inflammation increases the frequency of expression of an intestinal goblet-cell phenotype and p53 in the cancers.
Source: Journal of Clinical Pathology - February 21, 2013 Category: Pathology Authors: Hughes, N. R., Bhathal, P. S. Tags: Pancreas and biliary tract, Immunology (including allergy), Breast cancer, Hepatic cancer, Inflammation Original article Source Type: research

SP3, a reliable alternative to HercepTest in determining HER-2/neu status in breast cancer patients
Accurate assessment of HER-2/neu gene status in breast cancer patients has important prognostic and therapeutic implications. Overexpression/gene amplification of HER-2 is associated with a more aggressive clinical course and eligibility for targeted therapy with trastuzumab. A variety of immunohistochemical (IHC) antibodies and in situ hybridisation (ISH) methods have been employed to assess HER-2 status. SP3 is a rabbit monoclonal antibody that has been shown to have a high level of agreement with other anti-HER-2 antibodies and ISH methods. We assessed HER-2 status by SP3 and HercepTest IHC stains and by fluorescence in...
Source: Journal of Clinical Pathology - April 21, 2013 Category: Pathology Authors: D'Alfonso, T. M., Liu, Y.-F., Chen, Z., Chen, Y.-B., Cimino-Mathews, A., Shin, S. J. Tags: Immunology (including allergy), Breast cancer, Clinical diagnostic tests Original article Source Type: research

Use of immunohistochemistry in the diagnosis of problematic breast lesions
This article reviews the common uses of immunohistochemistry in diagnostic breast pathology. It is important to be aware of the limitations of individual antibodies. Such problems can often be overcome by using panels of antibodies. Quality control is also essential: internal and external controls should show appropriate staining. Immunohistochemistry must be interpreted in combination with the morphology seen on H&E sections. Myoepithelial markers, such as smooth muscle actin, smooth muscle myosin heavy chain and p63, are useful for distinguishing invasive carcinoma from sclerosing lesions and ductal carcinoma in situ...
Source: Journal of Clinical Pathology - May 22, 2013 Category: Pathology Authors: Lee, A. H. S. Tags: Immunology (including allergy), Breast cancer, Skin cancer, Gynecological cancer, Lung cancer (oncology), Lung cancer (respiratory medicine), Dermatology Review Source Type: research

Occurrence and significance of epithelial-mesenchymal transition in breast cancer
By contrast with developmental epithelial-mesenchymal transition (EMT), where epithelial characteristics undergo transformation to a mesenchymal-like phenotype in a coordinated fashion, oncogenic EMT occurs in the context of unpredictable genetic changes present in the tumour cells, as well as an abnormal tumour microenvironment. Therefore, a partial form of EMT has been proposed as variably participating in the establishment of invasive phenotype in different types of breast carcinoma, in keeping with their morphological and phenotypical diversity. A complex network of signalling pathways and transcription factors appears...
Source: Journal of Clinical Pathology - May 22, 2013 Category: Pathology Authors: Roxanis, I. Tags: Immunology (including allergy), Breast cancer, Molecular biology Review Source Type: research

UK cancer treatment: When ‘out of the ordinary’ means ‘out of luck’
Lynne Hazelden is caught in a bureaucratic nightmare – and nothing less than her life is at stake
Source: Alliance for Natural Health - July 17, 2013 Category: Complementary Medicine Authors: Adam Tags: allergies allergy breast cancer carcinoma ductal europe Grade III Hazelden international Lynne Hazelden mercury NHS pathways Source Type: news

Clinicopathological significance of HER2/neu genetic heterogeneity in HER2/neu non-amplified invasive breast carcinomas and its concurrent axillary metastasis
Conclusions HER2 GH is present in 27% of breast carcinomas, portends an aggressive phenotype and contributes to the equivocal HER2 status. Evaluation of the HER2 status in nodal metastasis of select primary carcinomas with GH may be beneficial before treatment selection.
Source: Journal of Clinical Pathology - July 22, 2013 Category: Pathology Authors: Shafi, H., Astvatsaturyan, K., Chung, F., Mirocha, J., Schmidt, M., Bose, S. Tags: Immunology (including allergy), Breast cancer Original article Source Type: research

Ductal carcinoma in situ associated with triple negative invasive breast cancer: evidence for a precursor-product relationship
Conclusions Our data support the notion that triple negative ductal carcinoma in situ is the precursor of the corresponding invasive counterpart, and that basal-like expression is maintained in the majority of invasive cancers associated with basal-like in situ disease. Future studies that prospectively evaluate morphological and biological characteristics of invasive cancers that develop from triple negative and basal-like ductal carcinoma in situ lesions will assist in validating these findings.
Source: Journal of Clinical Pathology - July 22, 2013 Category: Pathology Authors: Thike, A. A., Iqbal, J., Cheok, P. Y., Tse, G. M.-K., Tan, P. H. Tags: JCP Education, Immunology (including allergy), Breast cancer Original article Source Type: research

p63 And p53 expression in extranodal NK/T cell lymphoma, nasal type
Objectives To investigate the pathological and clinical meaning of p63 in extranodal nasal type NK/T cell lymphoma (NKTCL). Methods We detected p63 and p53 expression using immunohistochemistry staining in 84 cases of NKTCL from Southern of China, an area with a well known high incidence of nasopharyngeal carcinoma, which is closely associated with Epstein–Barr virus infection. Moreover, we analysed the relationship between p63 and p53 expression and the clinicopathological features of NKTCL. Results Our results first showed that p63 expression was found in 14.3% (12/84) of NKTCL compared with 6.6% (2/30) in reacti...
Source: Journal of Clinical Pathology - July 22, 2013 Category: Pathology Authors: Ye, Z., Cao, Q., Niu, G., Liang, Y., Liu, Y., Jiang, L., Yu, X., Han, A. Tags: Immunology (including allergy), Breast cancer, Head and neck cancer, Ear, nose and throat/otolaryngology Original article Source Type: research

Strong association of fascin expression with triple negative breast cancer and basal-like phenotype in African-American women
Conclusion These results suggest that fascin is a marker for TN subtype having a basal-like phenotype and decreased overall survival. Fascin may represent a target for therapy in TNBC in AA women.
Source: Journal of Clinical Pathology - January 15, 2014 Category: Pathology Authors: Esnakula, A. K., Ricks-Santi, L., Kwagyan, J., Kanaan, Y. M., DeWitty, R. L., Wilson, L. L., Gold, B., Frederick, W. A. I., Naab, T. J. Tags: Immunology (including allergy), Breast cancer Original article Source Type: research

HER2 testing for breast carcinoma: recommendations for rapid diagnostic pathways in clinical practice
Human epidermal growth factor receptor 2 (HER2) testing is required for newly diagnosed breast cancer and advised for recurrent and metastatic breast cancer, to determine treatment planning using HER2-directed therapy in the neoadjuvant, adjuvant and advanced disease settings. Wide variation, nationally, in the turnaround time for HER2 testing may hinder equity of access for patients to both clinical trials and the timely implementation of HER2-directed therapy particularly in the neo-adjuvant setting. Process mapping from three recognised laboratories in the UK was applied to the logistics of HER2 testing in different geo...
Source: Journal of Clinical Pathology - January 15, 2014 Category: Pathology Authors: Shaaban, A. M., Purdie, C. A., Bartlett, J. M. S., Stein, R. C., Lane, S., Francis, A., Thompson, A. M., Pinder, S. E., on behalf of the Translational Subgroup of the NCRI Breast Clinical Studies Group Tags: Immunology (including allergy), Breast cancer Original article Source Type: research