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Specialty: Cancer & Oncology
Cancer: Cancer

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Total 908 results found since Jan 2013.

Analysis of Epidemiological Characteristics of New Cardiovascular Diseases in Cancer Patients with Cardiovascular Disease
J Oncol. 2022 Aug 31;2022:5157398. doi: 10.1155/2022/5157398. eCollection 2022.ABSTRACTIn cancer patients, a cardiovascular disease (CVD) is a prevalent occurrence. When a patient has both heart disease and cancer, the treatment can be complicated because treatment for one condition can have an adverse effect on the outcome of the other. A cardiovascular disease that involves heart failures, coronary artery disease (CAD), stroke, pericardial diseases, arrhythmias, and valve and vascular dysfunction is a serious worry for long-term cancer patients. Because preclinical research is limited, it is critical to comprehend the pa...
Source: Journal of Oncology - September 12, 2022 Category: Cancer & Oncology Authors: Guangchong Zhang Yiwen Zhang Wenguan Li Source Type: research

Increased Carcinoembryonic Antigen (CEA) Level Is Highly Associated with Low Skeletal Muscle Mass in Asymptomatic Adults: A Population-Based Study
J Clin Med. 2022 Aug 26;11(17):5009. doi: 10.3390/jcm11175009.ABSTRACTWe investigated the relationship between high carcinoembryonic antigen (CEA) levels and low skeletal muscle mass (LMM) in asymptomatic adults in a population-based study. A total of 202,602 adults (mean age 41.7 years) without malignancy, stroke, cardiovascular disease, or chronic lung/liver disease were included. A high CEA level was defined as ≥5 ng/mL. Skeletal muscle mass index (SMI) was calculated based on appendicular muscle mass (kg)/height (m)2. Participants were classified into three groups based on SMI: "normal", "mild LMM", and "severe LMM."...
Source: Clinical Lung Cancer - September 9, 2022 Category: Cancer & Oncology Authors: Chul-Hyun Park Antonio Diaz Lizarraga Yong-Taek Lee Kyung-Jae Yoon Tae-Kyung Yoo Source Type: research

Recent advances in drug delivery and targeting to the brain
J Control Release. 2022 Aug 31:S0168-3659(22)00574-0. doi: 10.1016/j.jconrel.2022.08.051. Online ahead of print.ABSTRACTOur body keeps separating the toxic chemicals in the blood from the brain. A significant number of drugs do not enter the central nervous system (CNS) due to the blood-brain barrier (BBB). Certain diseases, such as tumor growth and stroke, are known to increase the permeability of the BBB. However, the heterogeneity of this permeation makes it difficult and unpredictable to transport drugs to the brain. In recent years, research has been directed toward increasing drug penetration inside the brain, and na...
Source: Cancer Control - September 3, 2022 Category: Cancer & Oncology Authors: Bharti Sethi Virender Kumar Kalika Mahato Donald W Coulter Ram I Mahato Source Type: research

Computed Tomography Angiography Quantification of Intracranial and Extracranial Vascular Narrowing in Ischemic Stroke: Differences Between Patients With and Without Illicit Drug Use
CONCLUSIONS: By using computed tomography angiography, we found that stroke patients with history of cocaine consumption had a higher incidence of intracranial circulation narrowing compared with matched controls.PMID:36055121 | DOI:10.1097/RCT.0000000000001367
Source: Cancer Control - September 2, 2022 Category: Cancer & Oncology Authors: Eliana Bonfante-Mejia Susana Calle Luis Nunez-Rubiano Azin Aein Xu Zhang Amanda Jagolino-Cole Source Type: research

Neuroprotective effects of tannic acid in the postischemic brain via direct chelation of Zn < sup > 2 < /sup >
Anim Cells Syst (Seoul). 2022 Aug 19;26(4):183-191. doi: 10.1080/19768354.2022.2113915. eCollection 2022.ABSTRACTTannic acid (TA) is a polyphenolic compound that exerts protective effects under pathological conditions. The diverse mechanisms of TA can exert beneficial anti-oxidative, anti-inflammatory, and anti-cancer effects. Herein, we reported that TA affords robust neuroprotection in an animal model of stroke (transient middle cerebral artery occlusion; tMCAO) and exhibits Zn2+-chelating and anti-oxidative effects in primary cortical neurons. Following tMCAO induction, intravenous administration of TA (5 mg/kg) suppres...
Source: Cancer Control - September 1, 2022 Category: Cancer & Oncology Authors: Seung Woo Kim Da Bin Kim Hong Seok Kim Source Type: research

Renal outcomes in valve-in-valve transcatheter versus redo surgical aortic valve replacement: A systematic review and meta-analysis
CONCLUSION: Renoprotective strategies should be put into place to prevent and reduce AKI incidence regardless of the treatment modality. Patients undergoing re-intervention for the aortic valve constitute a high-risk and frail population in which ViV-TAVR demonstrated it might be a feasible option for carefully selected patients. Long-term follow-up data and randomized control trials will be needed to evaluate mortality and morbidity outcomes between these 2 treatments.PMID:36040611 | DOI:10.1111/jocs.16890
Source: Cancer Control - August 30, 2022 Category: Cancer & Oncology Authors: Arian Arjomandi Rad Vinci Naruka Robert Vardanyan Mohammad Yousuf Salmasi Panagiotis T Tasoudis Simon Kendall Roberto Casula Thanos Athanasiou Source Type: research

Lost individual income due to severe health events: life-course perspective in the Northern Finland Birth Cohort 1966
CONCLUSIONS: Stroke and heart attack but not cancer have exogenous deleterious effects on individual economy, independently of early-life factors. The effects accelerate by time. Negative income trend in control men shows that severe health events do not explain all decrease in income.PMID:36040214 | DOI:10.1093/eurpub/ckac110
Source: Cancer Control - August 30, 2022 Category: Cancer & Oncology Authors: Ina Rissanen Iiro Nerg Leena Ala-Mursula Marko Korhonen Source Type: research

Cancers, Vol. 14, Pages 4162: PARP1: Liaison of Chromatin Remodeling and Transcription
o-Qi Wang Poly(ADP-ribosyl)ation (PARylation) is a covalent post-translational modification and plays a key role in the immediate response of cells to stress signals. Poly(ADP-ribose) polymerase 1 (PARP1), the founding member of the PARP superfamily, synthesizes long and branched polymers of ADP-ribose (PAR) onto acceptor proteins, thereby modulating their function and their local surrounding. PARP1 is the most prominent of the PARPs and is responsible for the production of about 90% of PAR in the cell. Therefore, PARP1 and PARylation play a pleotropic role in a wide range of cellular processes, such as DNA repair and ...
Source: Cancers - August 27, 2022 Category: Cancer & Oncology Authors: Wen Zong Yamin Gong Wenli Sun Tangliang Li Zhao-Qi Wang Tags: Review Source Type: research

Rare stroke mechanisms in 4154 consecutive patients: causes, predictors, treatment, and outcomes
CONCLUSIONS: RMS occurred in 5.3% of a large population of consecutive AISs and are most frequently related to medical interventions, cancer, and vasculitis. RMS patients have less traditional risk factors but more systemic comorbidities, hemorrhagic transformations, recurrences, and a worse long-term outcome. Identification of RMS has direct implications for early treatment and long-term outcome.PMID:35994133 | DOI:10.1007/s10072-022-06344-w
Source: Cancer Control - August 22, 2022 Category: Cancer & Oncology Authors: Alex Vicino Gaia Sirimarco Ashraf Eskandari Dimitris Lambrou Philippe Maeder Vincent Dunet Patrik Michel Source Type: research

Association between self-reported gingival bleeding and prevalent hypertension among adults in a cross-sectional study in Zhejiang province
Conclusion: Frequent gingival bleeding was positively associated with prevalent hypertension among men.PMID:35981987 | DOI:10.3760/cma.j.cn112338-20210922-00744
Source: Cancer Control - August 18, 2022 Category: Cancer & Oncology Authors: H Wang L L Chen Y Q Guan Y Cao D Shen K X Xie X Y Zhang C M Wang P Pei Y Guo M Yu L M Chen Liming Li Source Type: research

Short ‐term outcomes in patients with lung cancer‐associated acute ischemic stroke
ConclusionIn this study, we have identified three independent risk factors associated with poor short-term outcomes in pLCAIS: higher NC, CRP, and D-dimer levels. These findings may be helpful for clinicians in identifying poor short-term outcomes patients.
Source: Thoracic Cancer - August 18, 2022 Category: Cancer & Oncology Authors: Ruixia Wang, Peijun Xu, Jun Zhou, Yuanyuan Meng, Kun Men, Jinyuan Zhang, Wei Lu, Juanjuan Xue, Xin Li Tags: ORIGINAL ARTICLE Source Type: research

Incidence, early case fatality and determinants of stroke in Iran: Golestan Cohort Study
CONCLUSION: Efficient risk factor control can considerably reduce stroke occurrence and fatality in our study. Establishing awareness campaigns and 24-hour stroke units seem necessary for improving the stroke management in this area.PMID:35973398 | DOI:10.1016/j.jstrokecerebrovasdis.2022.106658
Source: Cancer Control - August 16, 2022 Category: Cancer & Oncology Authors: Nazgol Motamed-Gorji Sanam Hariri Sahar Masoudi Maryam Sharafkhah Mahdi Nalini Shahram Oveisgharan Masoud Khoshnia Nogol Motamed-Gorji Abdolsamad Gharavi Arash Etemadi Hossein Poustchi Ramin Zand Reza Malekzadeh Source Type: research

Associations Between Adherence to Evidence-Based, Stroke Quality Indicators and Outcomes of Acute Reperfusion Therapy
CONCLUSIONS: We demonstrated national marked and sustainable improvement in adherence to door-to-needle time, door-to-puncture time, and successful reperfusion from 2013 to 2017 in Japan in patients with acute ischemic stroke. Adhering to the key QIs substantially affected in-hospital outcomes, underlining the importance of monitoring the quality of care using evidence-based QIs and the nationwide Close The Gap-Stroke program.PMID:35971841 | DOI:10.1161/STROKEAHA.121.038483
Source: Cancer Control - August 16, 2022 Category: Cancer & Oncology Authors: Nice Ren Soshiro Ogata Eri Kiyoshige Kunihiro Nishimura Ataru Nishimura Ryu Matsuo Takanari Kitazono Takahiro Higashi Kuniaki Ogasawara Koji Iihara Close The Gap-Stroke, J-ASPECT Study Collaborators Source Type: research

RNA splicing: a dual-edged sword for hepatocellular carcinoma
AbstractRNA splicing is the fundamental process that brings diversity at the transcriptome and proteome levels. The spliceosome complex regulates minor and major processes of RNA splicing. Aberrant regulation is often associated with different diseases, including diabetes, stroke, hypertension, and cancer. In the majority of cancers, dysregulated alternative RNA splicing (ARS) events directly affect tumor progression, invasiveness, and often lead to poor survival of the patients. Alike the rest of the gastrointestinal malignancies, in hepatocellular carcinoma (HCC), which alone contributes to  ~ 75% of the liver cancer...
Source: Medical Oncology - August 16, 2022 Category: Cancer & Oncology Source Type: research