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Specialty: Cancer & Oncology
Cancer: Cancer

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Total 908 results found since Jan 2013.

Hydroxyurea lowers transcranial Doppler flow velocities in children with sickle cell anaemia in a Nigerian cohort
ConclusionHU appears to significantly reduce TCD velocities in Nigerian children with SCA and elevated velocities ≥170 cm/sec with beneficial effect on the haematological profile. HU may provide an effective approach to primary stroke prevention, particularly in Africa. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - April 2, 2015 Category: Cancer & Oncology Authors: IkeOluwa Lagunju, Biobele J. Brown, Olugbemiro Sodeinde Tags: Research Article Source Type: research

Abstract PD4-2: Cardiovascular toxicity following aromatase inhibitor use in 13,273 survivors cared for in a HMO
Discussion These results indicate that variation exists in the type of CVD events that occur in breast cancer patients receiving AIs in comparison to tamoxifen users. For example, the risk of ischemic disease or stroke was not elevated in those who used AIs only versus TAM users. However, overall CVD events were greater in women who used AIs only (or sequentially after TAM), especially if they received left-sided breast irradiation. While these observational study results require cautious interpretation, they provide a basis for comparing the benefits and risks of endocrine treatments. Citation Format: Reina Haque, Joanne ...
Source: Cancer Research - April 30, 2015 Category: Cancer & Oncology Authors: Haque, R., Schottinger, J. E., Shi, J., Chung, J., Avila, C., Amundsen, B., Chlebowski, R. T. Tags: Poster Discussion Abstracts Source Type: research

Reduction of risk of dying from tobacco-related diseases after quitting smoking in Italy.
CONCLUSIONS: Estimates of risk reduction by quitting smoking are useful to provide a sounder scientific basis for public health messages and clinical advice. PMID: 26108248 [PubMed - as supplied by publisher]
Source: Tumori - June 26, 2015 Category: Cancer & Oncology Tags: Tumori Source Type: research

Abstract 5577: Text-mining methods applied to clinical records support an association between androgen deprivation therapy and subsequent cardiometabolic disease
We conducted this study to examine the association of androgen deprivation therapy in the treatment of prostate cancer with future metabolic and cardiovascular disease.Here we utilize electronic medical record data from 1.8 million subjects in the Stanford Translational Research Integrated Database Environment. Specifically, we extracted ICD-9 diagnostic codes, patient medication lists and data from clinical notes using a previously validated text-analytics pipeline. Through this approach, we identified a cohort of 4,578 individuals with prostate cancer containing data on all defined covariates including Gleason score, age...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Nead, K. T., Gaskin, G. L., Chester, C., Shah, N. H., Leeper, N. J. Tags: Epidemiology Source Type: research

Mortality and Vascular Events Among Elderly Patients with Chronic Myeloid Leukemia (CML): A Retrospective Analysis of Linked Seer-Medicare Data
Conclusions Elderly CML patients had higher mortality and higher rates of MI, stroke, PE and PAD than non-cancer patients. Event rates were not elevated among TKI-treated (primary imatinib) patients, suggesting that VE risk in these CML patients was driven primarily by underlying factors associated with CML. Teaser TKI treatment of CML may be associated with vascular events (VE). We examined event rates and mortality among elderly CML and non-cancer patients using linked cancer registry and Medicare claims data, 2003-2010. CML patients had higher mortality and VE rates. Rates were not elevated among TKI (primarily imatinib...
Source: Clinical Lymphoma Myeloma and Leukemia - February 7, 2016 Category: Cancer & Oncology Source Type: research

Mortality and Vascular Events Among Elderly Patients With Chronic Myeloid Leukemia: A Retrospective Analysis of Linked SEER-Medicare Data
Conclusion Elderly patients with CML had greater mortality and greater rates of MI, stroke, PE, and PAD than did noncancer patients. The event rates were not elevated among the TKI-treated (primary imatinib) patients, suggesting that the VE risk in these patients with CML was driven primarily by the underlying factors associated with CML. Micro-Abstract Tyrosine-kinase inhibitor (TKI) treatment of chronic myeloid leukemia (CML) can be associated with vascular events (VEs). We examined the event rates and mortality among elderly patients with and without CML using linked cancer registry and Medicare claims data from 2003 t...
Source: Clinical Lymphoma Myeloma and Leukemia - March 21, 2016 Category: Cancer & Oncology Source Type: research

Marijuana use and inpatient outcomes among hospitalized patients: analysis of the nationwide inpatient sample database
In this study we examined the relationships between marijuana use and health outcomes among hospitalized patients, including hospitalized patients with and without a diagnosis of cancer.
Source: Cancer Medicine - November 27, 2016 Category: Cancer & Oncology Authors: Neomi Vin ‐Raviv, Tomi Akinyemiju, Qingrui Meng, Swati Sakhuja, Reid Hayward Tags: Original Research Source Type: research

Transcranial Doppler in hemoglobin SC disease
Conclusion: These results suggest that a different cut‐off value for abnormal TCD velocities could be considered for patients with HbSC. Additional studies are warranted to determine the actual risk of stroke in HbSC genotype associated with this possible TCD risk value.
Source: Pediatric Blood and Cancer - December 12, 2016 Category: Cancer & Oncology Authors: Camilo Vieira, Carolina Nogueira Costa Oliveira, Ludmila Ara újo Borges Figueiredo, Rayra Pereira Santiago, Corynne Stephanie Ahouefa Adanho, Sanzio Silva Santana, Caroline Lang Burak, Isa Menezes Lyra, Marilda Souza Goncalves Tags: Research Article Source Type: research

Prevalence of cardiovascular late sequelae in long ‐term survivors of childhood cancer: A systematic review and meta‐analysis
ConclusionThis review showed the vast range of cardiovascular late effects after childhood or adolescent cancer therapy. The differences between the papers prevented drawing a conclusive picture of the prevalence of cardiovascular late effects. Large cohort studies and better reporting are needed to improve the knowledge on this topic.
Source: Pediatric Blood and Cancer - February 16, 2017 Category: Cancer & Oncology Authors: Peter Scholz ‐Kreisel, Claudia Spix, Maria Blettner, Susan Eckerle, Jörg Faber, Philipp Wild, Hiltrud Merzenich, Ulrike Hennewig Tags: Research Article Source Type: research

Cancers, Vol. 12, Pages 189: Influence of Baseline Cardiovascular Comorbidities on Mortality after Androgen Deprivation Therapy for Metastatic Prostate Cancer
ih Shao Few studies have assessed the benefits of androgen deprivation therapy (ADT) in men with metastatic prostate cancer (PC; mPC) at an old age or with major cardiovascular conditions. A retrospective cohort consisted of 3835 men with newly diagnosed mPC from the Taiwan Cancer Registry of 2008–2014. Among them, 2692 patients received only ADT in the first year after the cancer diagnosis, and 1143 patients were on watchful waiting. The inverse probability of treatment-weighted Cox model was used to estimate the effects of ADT on all-cause mortality and PC-specific mortality according to age, and the...
Source: Cancers - January 11, 2020 Category: Cancer & Oncology Authors: Wu Fang Hwang Shih Shao Tags: Article Source Type: research

Oncotarget: DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques
(Impact Journals LLC) Oncotarget Volume 11, Issue 10 reported that the statistically associated Cp G sites were analyzed in blood samples from two separate atherothrombotic stroke cohorts, ischemic stroke-cohort 1: 37 atherothrombotic patients and 6 controls, ischemic stroke-cohort 2: 80 atherothrombotic patients and 184 controls.
Source: EurekAlert! - Cancer - March 13, 2020 Category: Cancer & Oncology Source Type: news

Heterogeneity of Treatment Effects for Intensive Blood Pressure Therapy by Individual Components of FRS: An Unsupervised Data-Driven Subgroup Analysis in SPRINT and ACCORD
CONCLUSION: Similar findings in patients with hypertensive with T2DM or without diabetes by multivariate subgrouping suggested that the individual components of the FRS could enrich or improve CVD risk assessment. Further research was required to clarify the potential mechanism.PMID:35187120 | PMC:PMC8850629 | DOI:10.3389/fcvm.2022.778756
Source: Cancer Control - February 21, 2022 Category: Cancer & Oncology Authors: Yaqian Wu Jianling Bai Mingzhi Zhang Fang Shao Honggang Yi Dongfang You Yang Zhao Source Type: research

Cancers, Vol. 14, Pages 1111: Cardiac Myxomas Resembling Malignant Neoplasia: Incidentally Diagnosed vs. Cerebral Embolized Myxomas
Conclusions: After the surgical removal of CM, the outcome is compromised if preoperative cerebral embolization occurs. Surgical treatment is therefore indicated as soon as possible, especially when CM have a non-solid surface, are localized in the left heart, and have a pedunculated attachment away from the fossa ovalis.
Source: Cancers - February 22, 2022 Category: Cancer & Oncology Authors: Salem Hillmer Friedrich Panholzer Saad Salem Frank Ernst Maetzler Puehler Lutter Schoeneich Haneya Cremer Schoettler Tags: Article Source Type: research

Dissecting neuropathic from poststroke pain: the white matter within
In this study, we address these issues comparing stroke location in a CPSP group of 35 patients with 2 control groups: 27 patients with CNNP and 27 patients with stroke without pain. Brain MRI images were analyzed by 2 complementary approaches: an exploratory analysis using voxel-wise lesion symptom mapping, to detect significant voxels damaged in CPSP across the whole brain, and a hypothesis-driven, region of interest-based analysis, to replicate previously reported sites involved in CPSP. Odds ratio maps were also calculated to demonstrate the risk for CPSP in each damaged voxel. Our exploratory analysis showed that, bes...
Source: Cancer Control - March 18, 2022 Category: Cancer & Oncology Authors: Marcelo Delboni Lemos Isabelle Faillenot Leandro Tavares Lucato Manoel Jacobsen Teixeira Luciana Mendon ça Barbosa Eduardo Joaquim Lopes Alho Adriana Bastos Conforto Antonia Lilian de Lima Rodrigues Ricardo Galhardoni Valqu íria Aparecida da Silva Clari Source Type: research

Cardiovascular conditions and obesity among gynecologic cancer survivors: Results from the 2020 behavioral risk factor surveillance system survey
CONCLUSIONS: Gynecologic cancer survivors are more likely than persons without a cancer history to have cardiovascular disease and other chronic illnesses, and they have a higher prevalence of heart attack, stroke, and obesity. These results underscore the sizeable opportunities for primary, secondary, and tertiary prevention of cardiovascular health conditions among gynecologic cancer survivors.PMID:35437169 | DOI:10.1016/j.ygyno.2022.03.025
Source: Gynecologic Oncology - April 19, 2022 Category: Cancer & Oncology Authors: Steven S Coughlin Biplab Datta Avirup Guha Xiaoling Wang Neal L Weintraub Source Type: research