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Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Exploring Cardiac Impact of Oral Nicotine Exposure in a Transplantable Neoplasm Mice Model: Insights from Biochemical Analysis, Morphometry, and Molecular Docking: Chlorella vulgaris Green Algae Support
This study was designed to investigate the impact of nicotine and Chlorella vulgaris (Ch. V) on cardiac glutathione homeostasis, inflammatory response, cardiac damage markers, apoptotic proteins and histopathological findings in an experimentally transplantable neoplasm mouse model (Ehrlich ascites carcinoma; EAC). In the in-vivo experiment, the female Swiss mice were divided into four groups: control, Ch.V (100mg/kg), Nicotine (100µg/ml/kg), and a combination group ( Nocotine+ Ch.V) for 40 days. Furthermore, the effects of C. vulgaris components on caspase-3, TNF-α, and IL-1β activity were explored using Molecular Oper...
Source: Toxicology - September 13, 2023 Category: Toxicology Authors: Amany Abdel-Rahman Mohamed Gihan G Moustafa Khlood M El Bohy Taghred M Saber Mohamed M M Metwally Heba El Desoukey Mohammed Ali H El-Far Badriyah S Alotaibi Manal Alosaimi Samah S Abuzahrah Leena S Alqahtani Source Type: research

Cigarette Smoking Abstinence Among Pregnant Individuals Using E-Cigarettes or Nicotine Replacement Therapy
CONCLUSIONS AND RELEVANCE: These findings suggest that individuals who used e-cigarettes during pregnancy had a higher smoking abstinence rate in late pregnancy than individuals who used NRT, especially for those who initiated e-cigarette use before pregnancy, indicating that replacement of cigarettes with e-cigarettes during pregnancy may be a viable strategy for harm reduction.PMID:37698863 | DOI:10.1001/jamanetworkopen.2023.30249
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Xiaozhong Wen Minseon V Chung Kayla A Liszewski Lauren D Todoro Eve M Giancarlo Wenxin Zhang Sara K Berkelhamer Maciej L Goniewicz Source Type: research

LINC01638 Sustains Human Mesenchymal Stem Cell Self-Renewal and Competency for Osteogenic Cell Fate
Res Sq. 2023 Aug 28:rs.3.rs-3210911. doi: 10.21203/rs.3.rs-3210911/v1. Preprint.ABSTRACTThe skeleton forms from multipotent human mesenchymal stem cells (hMSCs) competent to commit to specific lineages. Long noncoding RNAs (lncRNAs) have been identified as key epigenetic regulators of tissue development. However, regulation of osteogenesis by lncRNAs as mediators of commitment to the bone phenotype is largely unexplored. We focused on LINC01638, which is highly expressed in hMSCs and has been studied in cancers, but not in regulating osteogenesis. We demonstrated that LINC01638 promotes initiation of the osteoblast phenoty...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Jonathan Gordon Coralee E Tye Bodhisatwa Banerjee Prachi N Ghule Andre J Wijnen Fleur S Kabala Natalie A Page Michelle M Falcone Janet L Stein Gary S Stein Jane B Lian Source Type: research

Nicotinic acetylcholine receptors in cancer: Limitations and prospects
Biochim Biophys Acta Mol Basis Dis. 2023 Sep 4:166875. doi: 10.1016/j.bbadis.2023.166875. Online ahead of print.ABSTRACTNicotinic acetylcholine receptors (nAChRs) have long been considered to solely mediate neurotransmission. However, their widespread distribution in the human body suggests a more diverse physiological role. Additionally, the expression of nAChRs is increased in certain cancers, such as lung cancer, and has been associated with cell proliferation, epithelial-to-mesenchymal cell transition, angiogenesis and apoptosis prevention. Several compounds that interact with these receptors have been identified as po...
Source: Biochimica et Biophysica Acta - September 6, 2023 Category: Biochemistry Authors: T Bele T Turk I Kri žaj Source Type: research

Transcranial Direct Current Stimulation in Nicotine Use: Nursing Implications for Patient Outcomes
J Addict Nurs. 2023 Jul-Sep 01;34(3):E74-E78. doi: 10.1097/JAN.0000000000000542.ABSTRACTTobacco use is a leading cause of cancer, cardiovascular and respiratory disease, and preventable death in the United States. The brains of individuals with nicotine dependence are characterized by damaged mesolimbic pathways in the medial portion of the limbic and frontal lobes, creating positive reinforcing mechanisms. Transcranial direct current stimulation (tDCS) targets this neuroadaptation to improve smokers' nicotine-related outcomes, such as craving and smoking behavior, by depolarizing or hyperpolarizing the neurons of the brai...
Source: Cancer Control - September 5, 2023 Category: Cancer & Oncology Authors: Seok Hyun Gwon Han-Joo Lee Hyochol Brian Ahn Source Type: research

Effects of reduced nicotine content cigarette advertising with warning labels and social media features on product perceptions among young adults
This study sought to understand reactions to very low nicotine (VLN) cigarette advertising compared with conventional cigarette advertising with consideration of warning labels and social media context. The online experimental study recruited young adult cigarette smokers and nonsmokers (N = 1,608). Participants completed a discrete choice task with a 2 × 2 × 3 mixed design: brand, (VLN, Marlboro), context (Ad only, Ad on social media), and warning (Text-only, Well-known risk pictorial, or Lesser-known risk pictorial). Participants made choices about attention, appeal, harm, buying, and quitting intentions. Social media ...
Source: Cancer Control - August 21, 2023 Category: Cancer & Oncology Authors: Andrea C Johnson Melissa Mercincavage Andy S L Tan Andrea C Villanti Cristine D Delnevo Andrew A Strasser Source Type: research

Life's Essential 8 and Mortality in US Adults with Chronic Kidney Disease
CONCLUSIONS: The current study demonstrates that adherence to higher LE8 levels within CKD individuals is associated with a reduced risk of both all-cause and cause-specific mortality.PMID:37591229 | DOI:10.1159/000533257
Source: American Journal of Nephrology - August 17, 2023 Category: Urology & Nephrology Authors: Hongyu Chen Haoxian Tang Jingtao Huang Nan Luo Xuan Zhang Xin Wang Source Type: research