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Total 649 results found since Jan 2013.
Comparative Evaluation of Captopril, Spironolactone, and Carvedilol Effect on Endothelial Function in Breast Cancer Women Undergoing Chemotherapy
CONCLUSION: Prescribing combination of Carvedilol, Spironolactone, and Captopril in breast cancer patients undergoing chemotherapy can improve endothelial function and may have beneficial effects on diastolic function.PMID:37434915 | PMC:PMC10331532 | DOI:10.4103/abr.abr_81_21
Source: Biomed Res - July 12, 2023 Category: Research Authors: Seyed Mohammad Hashemi Jazi Faranak Tayebi Zahra Teimouri-Jervekani Fariborz Mokarian Valiallah Mehrzad Alireza Sadeghi Source Type: research
Evaluation of the Effect of Carvedilol in Preventing Right Ventricular Dysfunction in Breast Cancer Patients Receiving Anthracycline
CONCLUSION: According to the results of the present study, the effect of using carvedilol as a preservative on improving RV function was seen compared to the control group, although this difference was not statistically significant.PMID:36926423 | PMC:PMC10012032 | DOI:10.4103/abr.abr_134_21
Source: Cancer Control - March 17, 2023 Category: Cancer & Oncology Authors: Mersede Karvandi Mojtaba Ghadyani Nahid Mohebbi Mehdi Tabarraee Sina Salari Source Type: research
Potential cardioprotective and anticancer effects of carvedilol either free or as loaded nanoparticles with or without doxorubicin in solid Ehrlich carcinoma-bearing mice
CONCLUSION: CAR could be used as an adjuvant therapy with DOX, especially when nanoformualted with PLGA and even better with Niosomes, without compromising its cytotoxicity against cancer cells and preventing its cardiotoxic impacts.PMID:36921847 | DOI:10.1016/j.taap.2023.116448
Source: Toxicology and Applied Pharmacology - March 15, 2023 Category: Toxicology Authors: Amr Zidan Amira A El Saadany Gamal M El Maghraby Amany A Abdin Sabeha E Hedya Source Type: research
Beta-Blockers for Primary Prevention of Anthracycline-Induced Cardiac Toxicity: An Updated Meta-Analysis of Randomized Clinical Trials
CONCLUSION: Treatment with beta-blockers prevents dilatation of the left ventricle, development of diastolic dysfunction, and reduction of LVEF. However, these hemodynamic effects do not translate into a significant reduction in CTRCD incidence and prevention of hospitalization for heart failure or cardiac death.PMID:36687509 | PMC:PMC9818032 | DOI:10.1155/2022/8367444
Source: Cancer Control - January 23, 2023 Category: Cancer & Oncology Authors: Armin Attar Arman Karimi Behnagh Mehrasa Hosseini Foad Amanollahi Paria Shafiekhani Ali Kabir Source Type: research
The role of ARID1A in the non-estrogenic modulation of IGF-1 signaling
This study underscores the possibility of the pharmacologic modulation of the ARID1A factor to down-regulate pro-tumorigenic IGF-1 activity in postmenopausal breast cancer patients undergoing aromatase inhibitor treatment.PMID:35320351 | DOI:10.1158/1541-7786.MCR-21-0961
Source: Cell Research - March 23, 2022 Category: Cytology Authors: Sham Jdeed Edina Erdos Balint Laszlo Balint Ivan P Uray Source Type: research
Resveratrol significantly improves cell survival in comparison to dexrazoxane and carvedilol in a h9c2 model of doxorubicin induced cardiotoxicity
Biomed Pharmacother. 2021 May 17;140:111702. doi: 10.1016/j.biopha.2021.111702. Online ahead of print.ABSTRACTCancer is one of the leading causes of deaths worldwide with 18.1 million deaths per year. Although there have been significant advances in anti-cancer therapies, they can often result in side effects with cardiovascular complications being the most severe. Dexrazoxane is the only currently approved treatment for prevention of anthracycline induced cardiotoxicity but there are concerns about its use due to the development of secondary malignancies and myelodysplastic syndrome. Additionally, it is only recommended i...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 20, 2021 Category: Drugs & Pharmacology Authors: David S Monahan Eimhear Flaherty Aamir Hameed Garry P Duffy Source Type: research
Fight Aging! Newsletter, November 9th 2020
In this study, young adult mice were submitted to endurance exercise training and the function, differentiation, and metabolic characteristics of satellite cells were investigated in vivo and in vitro.
We found that injured muscles from endurance-exercised mice display improved regenerative capacity, demonstrated through higher densities of newly formed myofibres compared with controls (evidenced by an increase in embryonic myosin heavy chain expression), as well as lower inflammation (evidenced by quantifying CD68-marked macrophages), and reduced fibrosis. Enhanced myogenic function was accompanied by an increased ...
Source: Fight Aging! - November 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
