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CCL24 Signaling in the Tumor Microenvironment
Adv Exp Med Biol. 2021;1302:91-98. doi: 10.1007/978-3-030-62658-7_7.ABSTRACTChemokines with their network play an important role in cancer growth, metastasis, and host-tumor interactions. Of many chemokines, C-C motif chemokine ligand 24 (CCL24) has been shown to contribute to tumorigenesis as well as inflammatory diseases like asthma, allergies, and eosinophilic esophagitis. CCL24 is expressed in some tumor cells such as colon cancer, hepatocellular carcinoma, and cutaneous T cell lymphoma. CCL24 can be used as a potential biomarker in several cancers including colon cancer, non-small cell cancer, and nasopharyngeal carci...
Source: Advances in Experimental Medicine and Biology - July 21, 2021 Category: Research Authors: Sung-Jig Lim Source Type: research

How nanotechnology can flick the immunity switch
Nature, Published online: 30 June 2021; doi:10.1038/d41586-021-01790-6Nano immuno-engineering shows promise against autoimmune conditions, cancer and allergies.
Source: Nature AOP - June 30, 2021 Category: Research Authors: Bianca Nogrady Source Type: research

Current status and perspectives regarding the association between allergic disorders and cancer
AbstractWhile activation of immune system may lead to a lower risk of some diseases, it has been shown that a history of atopic allergic disorders such as asthma, hay fever, eczema, and food allergies could be related to several types of cancer. However, the evidence is not entirely conclusive. Two proposals suggest a possible mechanism for the association between allergic disorders and cancers: immune surveillance and the antigenic stimulation. The association of allergy and cancer may vary by cancer site and the type of exposure. The aim of current review was to summarize the current knowledge of the association between ...
Source: IUBMB Life - May 25, 2020 Category: Research Authors: Mohammad Fereidouni, Gordon A. Ferns, Afsane Bahrami Tags: CRITICAL REVIEW Source Type: research

The Epigenetics of Food Allergy.
Authors: Chang C, Wu H, Lu Q Abstract Food allergy is a global health problem, particularly in developed countries. It is mainly mediated by Th2 cell and IgE produced by B cells. While the pathogenesis of IgE-mediated food allergy is quite straightforward, the factors that lead to the development of food allergies at any age in children and adults are unclear. Recent studies have revealed that genetics, epigenetics, and environmental exposures contribute to the development of atopy. In this chapter, we discuss the interplay between these three key elements, reveal how epigenetic modifications may mediate genetic su...
Source: Advances in Experimental Medicine and Biology - May 25, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Involvement of Syndecan-1 and Heparanase in Cancer and Inflammation.
Authors: Teixeira FCOB, Götte M Abstract The cell surface heparan sulfate proteoglycan Syndecan-1 acts as an important co-receptor for receptor tyrosine kinases and chemokine receptors, and as an adhesion receptor for structural glycoproteins of the extracellular matrix. It serves as a substrate for heparanase, an endo-β-glucuronidase that degrades specific domains of heparan sulfate carbohydrate chains and thereby alters the functional status of the proteoglycan and of Syndecan-1-bound ligands. Syndecan-1 and heparanase show multiple levels of functional interactions, resulting in mutual regulation of their expr...
Source: Advances in Experimental Medicine and Biology - April 12, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Nanoparticles-Caused Oxidative Imbalance.
Authors: Zuberek M, Grzelak A Abstract Application of nanomaterials in nearly every single branch of industry results in their accumulation in both abiotic environment and tissues of living organisms. Despite the common use of nanomaterials, we are not able to precisely define their toxicity towards humans and surrounding biota. Although we were able to determine final effects of chronic exposure to nanoparticles which consist of many pathologies such as respiratory diseases, allergies, diseases of cardiovascular system, disorders in embryonic life differentiation and growth disorders, toxic effects on the immune s...
Source: Advances in Experimental Medicine and Biology - February 18, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research

Postepy Hig Med Dosw 2017; 71:446-453 "Immune disorders induced by exposure to pyrethroid insecticides"
Pyrethroids are biocides, which belong to the third generation of insecticides. They are used as biocides, insecticides and medicines. These agents react selectively, because they are less harmful to birds and mammals (due to poor intestinal absorption and rapid detoxification in the body of homeothermic organisms) and they are poisonous for fish and insects. The aim of the article is to present the current state of knowledge on the effects of pyrethroids on the immune system based on the latest scientific research. The mechanism of action of pyrethroids include the delaying closure of voltage- sensitive sodium and chlor...
Source: Postepy higieny i medycyny doswiadczalnej - June 8, 2017 Category: Research Tags: Review article Source Type: research

Food Allergies More Widespread Among Inner-City Children - 8/14/14
A modified version of the Clostridium novyi (C. novyi-NT) bacterium can produce a strong and precisely targeted anti-tumor response in rats, dogs and now humans, according to a new report from Johns Hopkins Kimmel Cancer Center researchers.
Source: Johns Hopkins Medicine News - August 23, 2014 Category: Research Source Type: news

Updates on the web-based VIOLIN vaccine database and analysis system
The integrative Vaccine Investigation and Online Information Network (VIOLIN) vaccine research database and analysis system (http://www.violinet.org) curates, stores, analyses and integrates various vaccine-associated research data. Since its first publication in NAR in 2008, significant updates have been made. Starting from 211 vaccines annotated at the end of 2007, VIOLIN now includes over 3240 vaccines for 192 infectious diseases and eight noninfectious diseases (e.g. cancers and allergies). Under the umbrella of VIOLIN, >10 relatively independent programs are developed. For example, Protegen stores over 800 protecti...
Source: Nucleic Acids Research - December 28, 2013 Category: Research Authors: He, Y., Racz, R., Sayers, S., Lin, Y., Todd, T., Hur, J., Li, X., Patel, M., Zhao, B., Chung, M., Ostrow, J., Sylora, A., Dungarani, P., Ulysse, G., Kochhar, K., Vidri, B., Strait, K., Jourdian, G. W., Xiang, Z. Tags: VI. Genomic variation, diseases and drugs Source Type: research

Mayo Clinic in Arizona Part of Study to Help Regulate Immune System
Researchers from Mayo Clinic and the University of Arizona are shedding light on a mechanism in the human body that may result in more effective treatments for conditions such as autoimmune disorders, cancer, allergies and chronic inflammation.
Source: Mayo Clinic Research News - August 13, 2013 Category: Research Authors: Mayo Clinic Source Type: news

Toll-Like Receptor Polymorphisms, Inflammatory and Infectious Diseases, Allergies, and Cancer
Journal of Interferon & Cytokine Research , Vol. 0, No. 0.
Source: Journal of Interferon - May 15, 2013 Category: Research Tags: article Source Type: research

15kD Granulysin for Monocyte Differentiation: A New Immunotherapeutic for Both in vivo and ex vivo Applications
Granulysin is a cytolytic and proinflammatory molecule expressed by activated human cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. It has been implicated in many of diseases including infection, cancer, transplantation, autoimmunity, skin and reproductive maladies. Small synthetic forms of granulysin are being developed as novel antibiotics and studies suggest that granulysin may be a useful diagnostic biomarker and/or therapeutic for a wide variety of diseases. The invention relates to methods of stimulating or enhancing an immune response using 15 kD granulysin. Investigators at the NIH have discovered tha...
Source: NIH OTT Licensing Opportunities - April 20, 2010 Category: Research Authors: admin Source Type: research

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