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The Role of Beta-Blockers in the Treatment of Hypertension.
CONCLUSIONS AND RELEVANCE: Primary/essential hypertension in younger/middle-age is underpinned by high sympathetic nerve activity. In this age-group high resting heart rates and high plasma norepinephrine levels (independent of blood pressure) are linked to premature cardiovascular events and death. Thus, anti-hypertensive agents that increase sympathetic nerve activity ie diuretics, dihydropyridine calcium blockers, and ARBs, are inappropriate first-line choices in this younger age-group. Beta-blockers perform well vs randomised placebo and other antihypertensive agents regarding reduced risk of death/stroke/myocardial in...
Source: Advances in Experimental Medicine and Biology - December 14, 2016 Category: Research Tags: Adv Exp Med Biol Source Type: research

Relationships between Chronic Diseases and Depression among Middle-aged and Elderly People in China: A Prospective Study from CHARLS
SummaryGiven the rapid increase in the prevalence of chronic diseases in aging populations, this prospective study including 17 707 adults aged ≥45 years from China Health and Retirement Longitudinal Study was used to estimate the associations between chronic disease, multimorbidity, and depression among middle-aged and elderly adults in China, and explore the mediating factors. Depressive symptoms were assessed using the 10-item Centre f or Epidemiological Studies Depression Scale (CES-D-10) questionnaire. Twelve chronic physical conditions, including hypertension, diabetes, dyslipidemia, cancer, chronic lung disease, l...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 1, 2020 Category: Research Source Type: research

Methods of preventing tissue ischemia
The National Cancer Institute ' s Laboratory of Pathology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize therapeutics targeting vasodialation. Nitric oxide (NO) plays an important role as a major intrinsic vasodilator, and increases blood flow to tissues and organs. Disruption of this process leads to peripheral vascular disease, ischemic heart disease, stroke, vascular insufficiency associated with diabetes, and many more diseases that are significant. Researchers at the NIH have discovered that the matrix protein thrombospon...
Source: NIH OTT Licensing Opportunities - January 1, 2018 Category: Research Authors: ott-admin Source Type: research

Real-world impact of disease on functioning and activity: what is missed when using general instruments to estimate quality-adjusted life year
CONCLUSION: Differences in rankings of disease severity by metric indicate that the results of cost-utility analyses might be biased against treatments for certain diseases. As patient preferences for clinical outcomes vary, the full burden of disease should be considered in evaluations. Restricting access to treatments based on an incomplete estimate of burden could lead to misallocation of resources and a withholding of therapies that patients find valuable.PMID:34775901 | DOI:10.1080/03007995.2021.2006535
Source: Current Medical Research and Opinion - November 15, 2021 Category: Research Authors: Tingjian Yan Jesse D Ortendahl Eunice Chang Zac Wessler Amanda L Harmon Michael S Broder Source Type: research

Methods of Preventing Tissue Ischemia
Nitric oxide (NO) plays an important role as a major intrinsic vasodilator, and increases blood flow to tissues and organs. Disruption of this process leads to peripheral vascular disease, ischemic heart disease, stroke, diabetes, and many more significant diseases. Researchers at the NIH have discovered that the matrix protein thrombospondin-1 blocks the beneficial effects of NO, and prevents it from dilating blood vessels and increasing blood flow to organs and tissues. Additionally, the inventors discovered that this regulation requires interaction with thrombospondin-1's cell receptor CD47. Murine studies revealed that...
Source: NIH OTT Licensing Opportunities - August 1, 2008 Category: Research Authors: admin Source Type: research

Comorbid diseases and conditions in people with HIV in the UK
CONCLUSIONS: PLHIV in the UK were at a higher risk of developing a number of comorbid conditions, highlighting the need for regular attendance of health reviews such as the annual health reviews recommended by the British HIV Associations (BHIVA) quality standard for care, which are currently not uniformly conducted.PMID:34761727 | DOI:10.1080/03007995.2021.2003671
Source: Current Medical Research and Opinion - November 11, 2021 Category: Research Authors: Bethan I Jones Andrew Freedman Melissa J Thomas Celia Villalba-Mendez Leena Sathia Deborah Flanagan Scott Francis Craig J Currie Source Type: research

Adiponectin as a routine clinical biomarker.
Abstract Adiponectin is a protein synthesized and secreted predominantly by adipocytes into the peripheral blood. However, circulating adiponectin level is inversely related with body weight, especially visceral fat accumulation. The mechanism of this paradoxical relation remains obscure. Low circulating adiponectin concentrations (hypoadiponectinemia; <4 μg/mL) are associated with a variety of diseases, including dysmetabolism (type 2 diabetes, insulin resistance, hypertension, dyslipidemia, metabolic syndrome, hyperuricemia), atherosclerosis (coronary artery disease, stroke, peripheral artery disease), slee...
Source: Clin Med Res - January 1, 2014 Category: Research Authors: Kishida K, Funahashi T, Shimomura I Tags: Best Pract Res Clin Endocrinol Metab Source Type: research

Genetic & epigenetic approach to human obesity.
Genetic & epigenetic approach to human obesity. Indian J Med Res. 2014 Nov;140(5):589-603 Authors: Rao KR, Lal N, Giridharan NV Abstract Obesity is an important clinical and public health challenge, epitomized by excess adipose tissue accumulation resulting from an imbalance in energy intake and energy expenditure. It is a forerunner for a variety of other diseases such as type-2-diabetes (T2D), cardiovascular diseases, some types of cancer, stroke, hyperlipidaemia and can be fatal leading to premature death. Obesity is highly heritable and arises from the interplay of multiple genes and environme...
Source: Indian J Med Res - November 1, 2014 Category: Research Authors: Rao KR, Lal N, Giridharan NV Tags: Indian J Med Res Source Type: research

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