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Disproportionally low funding for trauma research by the National Institutes of Health: A call for a National Institute of Trauma
CONCLUSION Given the extreme burden of trauma-related disability and years of life lost, this review of extramural NIH funding definitively demonstrates that trauma is severely underfunded. The lack of a dedicated home for trauma research at NIH leads to a diffusion of grants across many institutes and makes it impossible to direct a focused and effective national research endeavor to improve outcomes. These data demonstrate the need for a National Institute of Trauma at the NIH to help set an agenda to reach the national goal of Zero Preventable Deaths.
Source: The Journal of Trauma: Injury, Infection, and Critical Care - December 21, 2019 Category: Orthopaedics Tags: AAST 2019 PODIUM PAPERS Source Type: research

Prevalence of Frequent Mental Distress Among Illinois Adults With Chronic Conditions: Estimates From the Behavioral Risk Factor Surveillance System, 2011 to 2017.
CONCLUSIONS: Social stigmas related to depression and anxiety may lead to the underreporting of FMD. Chronic disease management programs in Illinois should consider integrating mental health services. PMID: 32133865 [PubMed - as supplied by publisher]
Source: American Journal of Health Promotion : AJHP - March 4, 2020 Category: International Medicine & Public Health Authors: Price JD, Amerson NL, Barbour KE, Emuze DV Tags: Am J Health Promot Source Type: research

DWI-MRI can solve pediatric arthritis with no contrast
Diffusion-weighted MR imaging (DWI-MRI) has proven accuracy in diagnosing and...Read more on AuntMinnie.comRelated Reading: DWI-MRI predicts stroke recurrence in low-risk patients AI can differentiate parkinsonism on DWI-MRI DWI helps predict breast cancer cases with metastasis DWI-MRI may be best for indeterminate lung nodules Novel MRI scanner fits extremity imaging like a glove
Source: AuntMinnie.com Headlines - March 16, 2020 Category: Radiology Source Type: news

New DWI-MRI protocol looks promising for breast imaging
A promising MRI protocol for diffusion-weighted imaging (DWI-MRI) resulted...Read more on AuntMinnie.comRelated Reading: DWI-MRI can solve pediatric arthritis with no contrast DWI-MRI predicts stroke recurrence in low-risk patients Ariz. group follows MUSE to 15-minute MRI scans Focus on FOCUS, a new DWI-MRI protocol for breast lesions Breast MRI technique helps cancer detection without contrast
Source: AuntMinnie.com Headlines - June 8, 2020 Category: Radiology Source Type: news

Diagnosis to therapy: The future of image-guided patient management
(Society of Nuclear Medicine and Molecular Imaging) SNMMI's Virtual Annual Meeting will convene more than 6,000 attendees from around the globe to share novel research on new and better ways to diagnose and treat cancers, inflammation, arthritis, chronic pain, stroke, brain disease, and more.The focus is on precision medicine--improving patients' lives by developing new ways to diagnose earlier and more accurately, delivering the most effective therapy for a specific patient's disease, and monitoring and adjusting treatment to ensure optimum results.
Source: EurekAlert! - Cancer - July 7, 2020 Category: Cancer & Oncology Source Type: news

Mammography use in relation to comorbidities and functional limitations among older breast cancer survivors
ConclusionsA higher burden of functional limitations, not comorbidities, is associated with a lower rate of mammography use among older breast cancer survivors.Implications for cancer survivorsInterventions are needed to individualize surveillance mammography among older breast cancer survivors based on their health status.
Source: Journal of Cancer Survivorship - July 27, 2020 Category: Cancer & Oncology Source Type: research

Mitoxantrone, pixantrone and mitoxantrone (2-hydroxyethyl)piperazine are toll-like receptor 4 antagonists, inhibit NF- κB activation, and decrease TNF-alpha secretion in primary microglia.
This study thus identifies a new mechanism of action for mitoxantrone, pixantrone, and mitoxantrone (2-hydroxyethyl)piperazine through the TLR4. PMID: 32730846 [PubMed - as supplied by publisher]
Source: European Journal of Pharmaceutical Sciences - July 26, 2020 Category: Drugs & Pharmacology Authors: Rinne M, Mätlik K, Ahonen T, Vedovi F, Zappia G, Moreira VM, Yli-Kauhaluoma J, Leino S, Salminen O, Kalso E, Airavaara M, Xhaard H Tags: Eur J Pharm Sci Source Type: research

IJERPH, Vol. 17, Pages 6348: Coexistence of Lack of Clinical Manifestation of Oral Mycosis and Systemic Diseases in Edentulous Patients Using Removable Prosthetic Restorations
Conclusions: The occurrence of systemic diseases in edentulous people using removable prosthetic restorations, and the subsequent use of medications for these diseases, may result in a lack of clinical symptoms of concomitant fungal infection of the oral mucosa.
Source: International Journal of Environmental Research and Public Health - August 30, 2020 Category: Environmental Health Authors: Gacon Wieczorek Tags: Article Source Type: research

Johnson & Johnson Reports 2020 Third-Quarter Results
New Brunswick, N.J. (October 13, 2020) – Johnson & Johnson (NYSE: JNJ) today announced results for third-quarter 2020. “Our third-quarter results reflect solid performance and positive trends across Johnson & Johnson, powered by better-than-expected procedure recovery in Medical Devices, growth in Consumer Health, and continued strength in Pharmaceuticals,” said Alex Gorsky, Chairman and Chief Executive Officer. “I am proud of the relentless passion and Credo-led commitment to patients and customers that our colleagues around the world continue to demonstrate as we boldly fight the COVID-19 pandemic. Our wo...
Source: Johnson and Johnson - October 13, 2020 Category: Pharmaceuticals Tags: Our Company Source Type: news

eAssist Dental Health Education Foundation Goes Over and Above to Drive Systemic Health
 Helping patients help themselves stay their healthiest SALT LAKE CITY, Oct. 26, 2020 /PRNewswire/ -- eAssist Dental Solutions, the nation ' s leading provider of virtual insurance and patient billing services for dental offices, proudly launches its new Dental Health Education Foundation, a nonprofit organization on a mission to spread awareness of the importance of dental cleanings. This year COVID-19 has helped bring to the attention of the public the devastating impact of inflammation on the body. Specifically, that increased systemic inflammation – which can be caused by oral inflammation du...
Source: Dental Technology Blog - November 7, 2020 Category: Dentistry Source Type: news

Racial and Ethnic Differences in Multimorbidity Changes Over Time
Background: Our understanding of how multimorbidity progresses and changes is nascent. Objectives: Assess multimorbidity changes among racially/ethnically diverse middle-aged and older adults. Design, Setting, and Participants: Prospective cohort study using latent class analysis to identify multimorbidity combinations over 16 years, and multinomial logistic models to assess change relative to baseline class membership. Health and Retirement Study respondents (age 51 y and above) in 1998 and followed through 2014 (N=17,297). Measures: Multimorbidity latent classes of: hypertension, heart disease,...
Source: Medical Care - April 15, 2021 Category: Health Management Tags: Original Articles Source Type: research

Molecules, Vol. 26, Pages 3208: Progress in PET Imaging of Neuroinflammation Targeting COX-2 Enzyme
hn Mann Neuroinflammation and cyclooxygenase-2 (COX-2) upregulation are associated with the pathogenesis of degenerative brain diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), epilepsy, and a response to traumatic brain injury (TBI) or stroke. COX-2 is also induced in acute pain, depression, schizophrenia, various cancers, arthritis and in acute allograft rejection. Positron emission tomography (PET) imaging allows for the direct measurement of in vivo COX-2 upregulation and thereby enables disease staging, therapy evaluation and aid quantifying target occupa...
Source: Molecules - May 27, 2021 Category: Chemistry Authors: Jaya Prabhakaran Andrei Molotkov Akiva Mintz J. John Mann Tags: Review Source Type: research

Cancers, Vol. 13, Pages 3368: Physical Comorbidities and Depression in Recent and Long-Term Adult Cancer Survivors: NHANES 2007 –2018
Cancers, Vol. 13, Pages 3368: Physical Comorbidities and Depression in Recent and Long-Term Adult Cancer Survivors: NHANES 2007–2018 Cancers doi: 10.3390/cancers13133368 Authors: Dafina Petrova Andrés Catena Miguel Rodríguez-Barranco Daniel Redondo-Sánchez Eloísa Bayo-Lozano Rocio Garcia-Retamero José-Juan Jiménez-Moleón María-José Sánchez Many adult cancer patients present one or more physical comorbidities. Besides interfering with treatment and prognosis, physical comorbidities could also increase the already heightened psychological risk of cancer patients. To test this possibility, we...
Source: Cancers - July 5, 2021 Category: Cancer & Oncology Authors: Dafina Petrova Andr és Catena Miguel Rodr íguez-Barranco Daniel Redondo-S ánchez Elo ísa Bayo-Lozano Rocio Garcia-Retamero Jos é-Juan Jiménez-Moleón Mar ía-José Sánchez Tags: Article Source Type: research

Trends in Meeting the Aerobic Physical Activity Guideline Among Adults With and Without Select Chronic Health Conditions, United States, 1998-2018
CONCLUSIONS: Although rising trends in physical activity levels among adults with chronic health conditions are encouraging for improving chronic disease management, current prevalence remains low, particularly among older adults. Increasing physical activity should remain a priority for chronic disease management and control.PMID:34465653 | DOI:10.1123/jpah.2021-0178
Source: Journal of Physical Activity and Health - September 1, 2021 Category: Sports Medicine Authors: John D Omura Eric T Hyde Giuseppina Imperatore Fleetwood Loustalot Louise Murphy Mary Puckett Kathleen B Watson Susan A Carlson Source Type: research

Synthetically-tailored and nature-derived dual COX-2/5-LOX inhibitors: Structural aspects and SAR
Eur J Med Chem. 2021 Aug 27;225:113804. doi: 10.1016/j.ejmech.2021.113804. Online ahead of print.ABSTRACTInflammation is a most complex pathological process that gives birth to different diseases. Different inflammatory mediators are released during an inflammation responsible for acute pain and chronic inflammatory diseases like cancer, asthma, rheumatoid arthritis, osteoarthritis, neurodegenerative diseases, metabolic and cardiovascular disorders. The arachidonic acid pathway, which results in the production of inflammatory mediators, provides several targets for anti-inflammatory intervention. The most popularly used me...
Source: European Journal of Medicinal Chemistry - September 3, 2021 Category: Chemistry Authors: Minakshi A Meshram Utkarsha O Bhise Priyanka N Makhal Venkata Rao Kaki Source Type: research