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A Genetic Variant of miR-34a Contributes to Susceptibility of Ischemic Stroke Among Chinese Population
This study was supported by National Natural Science Foundation of China (Nos. 81560552, 81260234), Natural Science Foundation of Guangxi Zhuang Autonomous Region (CN) (2017JJA180826), Innovation Project of Guangxi Graduate Education (CN) (201601009) and Key Laboratory Open Project Fund of Guangxi Zhuang Autonomous Region (CN) (kfkt20160064). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be fou...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

6-Bromoindirubin-3 ′-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver
In this study, we aimed to investigate the anti-aging effect, and molecular mechanism, of the novel anti-aging drug 6BIO on naturally aged mouse liver. Rapamycin, a well-known promising anti-aging drug that delays aging through mTOR-dependent autophagy (Zhou and Ye, 2018), was used as the positive control in the study. To our knowledge, this is the first study to demonstrate the effects of 6BIO treatment in models of natural aging. Our results indicated that 6BIO ameliorates the decline of liver function with age, including lipid metabolism disorder, and attenuates hepatocyte senescence in aged mice, as revealed by altera...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

Korean JLK Inspection launches AI-powered imaging diag system
Korean JLK Inspection said yesterday that it launched its AIHub artificial intelligence-powered medical image diagnostics platform. The newly launched AIHub system is designed to analyze images from a number of different imaging modalities, including magnetic resonance imaging, computed tomography, X-ray and mammography, the Seoul-based company said. JLK Inspection claims the system can detect and monitor for more than 30 medical conditions in 14 regions of the body. The company added that the system is focused on brain diseases and conditions including ischemic stroke, hemorrhagic stroke, brain aneurysm and Alzheimer̵...
Source: Mass Device - December 27, 2018 Category: Medical Devices Authors: Fink Densford Tags: Diagnostics Imaging Software / IT jlkinspection Source Type: news

Global, regional, and national burden of neurological disorders during 1990 –2015: a systematic analysis for the Global Burden of Disease Study 2015
Publication date: Available online 17 September 2017 Source:The Lancet Neurology Author(s): GBD 2015 Neurological Disorders Collaborator GroupValery LFeiginAmanuel AlemuAbajobirKalkidan HassenAbateFoadAbd-AllahAbdishakur MAbdulleSemaw FeredeAberaGebre YitayihAbyuMuktar BeshirAhmedAmani NidhalAichourIbtihelAichourMiloud Taki EddineAichourRufus OlusolaAkinyemiSamerAlabedRajaaAl-RaddadiNelsonAlvis-GuzmanAzmeraw T.AmareHosseinAnsariPalwashaAnwariJohanÄrnlövHamidAsayeshSolomon WeldegebrealAsgedomTesfay MehariAteyLeticiaAvila-BurgosEuripideFrinelG. ArthurAvokpahoAleksandraBaracMiguelBarbozaSuzanne LBarker-ColloTillBärnighaus...
Source: The Lancet Neurology - September 19, 2017 Category: Neurology Source Type: research

Neurological Diseases Cost The U.S. $800 Billion Each Year
Over 100 million Americans ― close to a third of the total population ― suffer from neurological diseases such as Alzheimer’s, multiple sclerosis, migraines, epilepsy and spinal cord injury.  These conditions put an enormous financial strain on the health care system, totaling nearly $800 billion in annual costs, according to a new report published in the journal Annals of Neurology. To put that into perspective, the figure exceeds the U.S. military budget by over $100 billion.  That number reflects the total cost of the nine most common neurological diseases, but the total costs related to th...
Source: Healthy Living - The Huffington Post - March 30, 2017 Category: Consumer Health News Source Type: news

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980 –2015: a systematic analysis for the Global Burden of Disease Study 2015
Publication date: 8–14 October 2016 Source:The Lancet, Volume 388, Issue 10053 Author(s): GBD 2015 Mortality and Causes of Death CollaboratorsHaidongWangMohsenNaghaviChristineAllenRyan MBarberZulfiqar ABhuttaAustinCarterDaniel CCaseyFiona JCharlsonAlan ZianChenMatthew MCoatesMeganCoggeshallLalitDandonaDaniel JDickerHolly EErskineAlize JFerrariChristinaFitzmauriceKyleForemanMohammad HForouzanfarMaya SFraserNancyFullmanPeter WGethingEllen MGoldbergNicholasGraetzJuanita AHaagsmaSimon IHayChantalHuynhCatherine OJohnsonNicholas JKassebaumYohannesKinfuXie RachelKulikoffMichaelKutzHmwe HKyuHeidi JLarsonJanniLeungXiaofengLiangS...
Source: The Lancet - October 6, 2016 Category: Journals (General) Source Type: research

In Little Rock, Alzheimer's Association President Calls for More Research
The number of Arkansans suffering from Alzheimer's disease is expected to increase almost 25 percent — from 54,000 to 67,000 — by 2025 as the state's population continues to age, according to Alzheimer's Association President and CEO Harry Johns. During a quick trip to Little Rock on Wednesday, Johns met with U.S. Rep. French Hill, R-Ark.; Gov. Asa Hutchinson; University of Arkansas for Medical Sciences staff and others working to combat the disease. Johns told Arkansas Business that the cost of care for Alzheimer's patients in the U.S. reached a "staggering" $236 billion this year. Johns also said th...
Source: Arkansas Business - Health Care - June 1, 2016 Category: American Health Source Type: news

Medical Research: The Best Investment We Can Make in Our Future
While the cure for cancer has been elusive, President Obama's National Cancer Moonshot initiative offers renewed hope that we could see breakthroughs in prevention, detection, and treatment for a disease that affects millions of Americans and their families. The cancer moonshot is the latest demonstration that Washington understands the potential for medical research to change lives and improve the health of all Americans. It builds on the bipartisan support we saw last fall when House and Senate negotiators agreed on a $2 billion budget increase for medical research through the National Institutes of Health (NIH). Today,...
Source: Science - The Huffington Post - February 18, 2016 Category: Science Source Type: news

Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program
The Brain and Body Donation Program (BBDP) at Banner Sun Health Research Institute (http://www.brainandbodydonationprogram.org) started in 1987 with brain‐only donations and currently has banked more than 1600 brains. More than 430 whole‐body donations have been received since this service was commenced in 2005. The collective academic output of the BBDP is now described as the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND). Most BBDP subjects are enrolled as cognitively normal volunteers residing in the retirement communities of metropolitan Phoenix, Arizona. Specific recruitment efforts are also dire...
Source: Neuropathology - January 26, 2015 Category: Neurology Authors: Thomas G. Beach, Charles H. Adler, Lucia I. Sue, Geidy Serrano, Holly A. Shill, Douglas G. Walker, LihFen Lue, Alex E. Roher, Brittany N. Dugger, Chera Maarouf, Alex C. Birdsill, Anthony Intorcia, Megan Saxon‐Labelle, Joel Pullen, Alexander Scroggins, J Tags: SYMPOSIUM: BRAIN BANK Source Type: research

We Must Beat Alzheimer's Before It Beats Us! And Here's How!
Alzheimer's Has Become the Scariest Disease of Later Life It's true. In a new Age Wave/Merrill Lynch study titled Health and Retirement: Planning for the Great Unknown, we surveyed a representative sample of over 3,000 Americans to uncover both their hopes and their concerns about health and healthcare expenses. Overwhelmingly, the study respondents said that the most important ingredient for a happy retirement is health. And while all diseases can disrupt both health and wealth in retirement, people of all ages now say the scariest disabling condition in later life is Alzheimer's disease. In fact, Alzheimer's was cited...
Source: Healthy Living - The Huffington Post - November 20, 2014 Category: Consumer Health News Source Type: news

Dementia research funding should be on same footing as cancer, says charity
This article was amended on Wednesday 11 December 2013. Alzheizmer's Research Trust is now called Alzheimer's Research UK. This has been corrected.DementiaMental healthMedical researchHaroon Siddiquetheguardian.com © 2013 Guardian News and Media Limited or its affiliated companies. All rights reserved. | Use of this content is subject to our Terms & Conditions | More Feeds
Source: Guardian Unlimited Science - December 11, 2013 Category: Science Authors: Haroon Siddique Tags: The Guardian Mental health News Medical research Society Dementia UK news Science Source Type: news