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Total 164 results found since Jan 2013.

Dabbling in Dentistry
Most people will experience dental pain or a dental complication at some point in their lives. Dental pain is an incredibly common complaint by people of all ages, especially those who lack dental insurance and suitable hygiene habits. Sometimes, though, poor dentition or injury is simply a result of bad luck. Patients often present to the ED hoping to find a dentist and an answer to their problems.   Your first thought? “I am not a dentist. What am I going to do?” You’re right to an extent. We are not dentists, and often feel we have little to offer patients for acute issues that require equipment we don’t have...
Source: The Procedural Pause - July 1, 2015 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs

Arch Developments Progress
In this study, full thickness penetrating wounds were surgically created in rat livers, which are highly vascularized parenchymal organs, and then either AC5(TM) or the fibrin sealant was applied in order to stop the bleeding. The time to hemostasis (TTH), which is the time required to stop bleeding, was measured.The average TTH after application of AC5 was significantly less than 30 seconds. The average TTH for the fibrin sealant was approximately 50% longer.AC5 was maintained at room temperature without requiring cold storage, whereas the fibrin sealant was maintained frozen during storage, in accordance with its prescri...
Source: Medical Hemostat - June 14, 2015 Category: Medical Equipment Authors: hemostatguy at gmail.com (hemostat guy) Source Type: blogs

Comparison between self‐assembling peptide nanofiber scaffold (SAPNS) and fibrin sealant in neurosurgical hemostasis
Abstract RADA16‐I is a synthetic type I self‐assembling peptide nanofiber scaffold (SAPNS) which may serve as a novel biocompatible hemostatic agent. Its application in neurosurgical hemostasis, however, has not been explored. Although RADA16‐I is nontoxic and nonimmunogenic, its intrinsic acidity may potentially provoke inflammation in the surgically injured brain. We conducted an animal study to compare RADA16‐I with fibrin sealant, a commonly used agent, with the hypothesis that the former would be a comparable alternative. Using a standardized surgical brain injury model, 30 Sprague–Dawley rats were randomize...
Source: Clinical and Translational Science - June 1, 2015 Category: Biomedical Science Authors: Fei‐fan Xu, Yue‐chun Wang, Stella Sun, Amy S.W. Ho, Derek Lee, Karrie M.Y. Kiang, Xiao‐qin Zhang, Wai‐man Lui, Bai‐yun Liu, Wu‐tian Wu, Gilberto K.K. Leung Tags: Communication Source Type: research

Black hemostatic sponge based on facile prepared cross-linked graphene
In this study, we demonstrate for the first time the remarkable hemostatic performance of a cross-linked graphene sponge (CGS) as a superb hemostat. The CGS can absorb plasma immediately (<40ms) to form a blood cell layer and promote subsequent clotting. The interaction between the interface of the CGS and blood cells reveals that the fast blood coagulation is primarily attributed to the enrichment of hemocytes and platelets on the wound surface. An in vitro dynamic whole-blood clotting test further highlights the effectiveness of the CGS. Considering the facile preparation, low cost, nontoxicity and long shelf life...
Source: Colloids and Surfaces B: Biointerfaces - May 12, 2015 Category: Biochemistry Source Type: research

Black hemostatic sponge based on facile prepared cross-linked graphene.
In this study, we demonstrate for the first time the remarkable hemostatic performance of a cross-linked graphene sponge (CGS) as a superb hemostat. The CGS can absorb plasma immediately (<40ms) to form a blood cell layer and promotes subsequent clotting. The interaction between the interface of the CGS and blood cells reveals that the fast blood coagulation is primarily attributed to the enrichment of hemocytes and platelets on the wound surface. An in vitro dynamic whole-blood clotting test further highlights the effectiveness of the CGS. Considering the facile preparation, low cost, nontoxicity, and long shelf life o...
Source: Colloids and Surfaces - May 11, 2015 Category: Biotechnology Authors: Quan K, Li G, Luan D, Yuan Q, Tao L, Wang X Tags: Colloids Surf B Biointerfaces Source Type: research

Photoselective Vaporesection of the Prostate with a Front-firing Lithium Triborate Laser: Surgical Technique and Experience After 215 Procedures
Conclusions PVRP is a novel technique that is effective and safe for treatment of benign prostatic hyperplasia. This technique retains the excellent hemostatic property of LBO lasers and has a short operation time and a high tissue removal rate. The problem of the lack of postoperative tissue samples for PVP is also overcome in PVRP. Patient summary We have developed a novel technique named photoselective vaporesection of the prostate (PVRP) with a front-firing green laser. Our results show that PVRP retains the excellent hemostatic property of a green laser, but has a much shorter operation time and a higher rate of tiss...
Source: European Urology - May 1, 2015 Category: Urology & Nephrology Source Type: research

Economic analysis of Evarrestâ,¢ compared with standard of care in Soft tissue and Hepatic Surgical Bleeding: a U.S. Hospital perspective
A recent Premier study reported that despite hemostat use, uncontrolled bleeding is prevalent across surgery types (32%-68%). Drawbacks of current hemostats include limitations with efficacy on first attempt and sub-optimal ease-of-use; thus, better hemostats are needed. A study was conducted to estimate the cost impact of a novel fibrin sealant patch (EVARREST™) versus standard of care (SoC) in soft tissue and hepatic surgical bleeding.
Source: Value in Health - May 1, 2015 Category: Global & Universal Authors: M. Corral, N. Ferko, A. Hogan, S. Hollmann, N. Jamous, J. Batiller, R. Kocharian Source Type: research

Use of a plant-based polysaccharide hemostat for the treatment of sternal bleeding after median sternotomy
Conclusion: Polysaccharide hemostats appear to be safe and effective for bleeding control of the sternum.
Source: Journal of Cardiothoracic Surgery - April 24, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Christoph SchmitzRalf Sodian Source Type: research

Johnson & Johnson (JNJ) Announces Additional FDA Indication for EVARREST Fibrin Sealant Patch
Johnson & Johnson (NYSE: JNJ) announced the following Monday:Unexpected and uncontrollable bleeding is an ongoing challenge for surgeons, including those who perform liver surgery. Based on recent data, the U.S. Food and Drug Administration has approved an additional indication for Ethicon's EVARREST Fibrin Sealant Patch, as an adjunct to hemostasis for control of bleeding during adult liver surgery. EVARREST is a novel convergence of biologics and medical device that rapidly and reliably stops problematic bleeding during surgery on the first attempt in indicated patients.A problematic bleeding situation—involving bl...
Source: Medical Hemostat - April 5, 2015 Category: Medical Equipment Authors: hemostatguy at gmail.com (hemostat guy) Source Type: blogs

Johnson & Johnson (JNJ) Announces Additional FDA Indication for EVARREST Fibrin Sealant Patch
Johnson & amp; Johnson (NYSE: JNJ) announced the following Monday: Unexpected and uncontrollable bleeding is an ongoing challenge for surgeons, including those who perform liver surgery. Based on recent data, the U.S. Food and Drug Administration has approved an additional indication for Ethicon ' s EVARREST Fibrin Sealant Patch, as an adjunct to hemostasis for control of bleeding during adult liver surgery. EVARREST is a novel convergence of biologics and medical device that rapidly and reliably stops problematic bleeding during surgery on the first attempt in indicated patients. A problematic bleeding situation —...
Source: Medical Hemostat - April 5, 2015 Category: Medical Equipment Authors: hemostatguy at gmail.com (hemostat guy) Source Type: blogs

Comparison of methods to achieve artery closure following coronary angiography
Stefanie Schulz-Schupke, M.D., of the Deutsches Herzzentrum Munchen, Technische Universitat, Munich, Germany and colleagues assessed whether vascular closure devices are noninferior (not worse than) to manual compression in terms of access site-related vascular complications in patients undergoing diagnostic coronary angiography. The study appears in the November 19 issue of JAMA, a cardiovascular disease theme issue.Percutaneous (through the skin) coronary angiography and interventions have become a cornerstone in the diagnosis and treatment of coronary artery disease. A substantial proportion of the adverse effects assoc...
Source: Medical Hemostat - November 16, 2014 Category: Technology Consultants Authors: hemostatguy at gmail.com (hemostat guy) Source Type: blogs

Start-up pitches high-tech glue for surgical leaks
TEL AVIV — An Israeli medical-device start-up is tackling one of the most dangerous occurrences in surgery — and it's doing it with glue.LifeSeal is a glue-like substance that augments and, in some surgeries like hernias, replaces the traditional and painful sealing procedures of staples, tacks and sutures.The privately-owned Israeli company behind the high-tech glue, LifeBond, says it should help in the treatment of post-operative leaks in closures of gastrointestinal and other surgical wounds. Patients get back up to speed more quickly and are more comfortable as they do.Orahn Preiss-Bloom, one of LifeBond's co-found...
Source: Medical Hemostat - November 16, 2014 Category: Technology Consultants Authors: hemostatguy at gmail.com (hemostat guy) Source Type: blogs

Synthetic platelets helps clot blood faster
New York: Taking a cue from the human body’s own blood-clotting process, researchers at University of California, Santa Barbara have developed synthetic platelets that can do more than clot blood.By creating nanoparticles that mimic the shape, flexibility and surface biology of the body’s own platelets, the team was able to accelerate natural healing processes while opening the door to therapies and treatments that can be customised to specific patient needs.“This is a significant milestone in the development of synthetic platelets, as well as in targeted drug delivery,” said Samir Mitragotri, director of Center fo...
Source: Medical Hemostat - November 16, 2014 Category: Technology Consultants Authors: hemostatguy at gmail.com (hemostat guy) Source Type: blogs

CD31+ cell transplantation promotes recovery from peripheral neuropathy
In this study, we investigated the beneficial effects of CD31+ cells on peripheral neuropathy in mice. CD31+ cells were collected from the peripheral blood using magnetic activated cell sorting. CD31+ cells exhibited higher levels of expression of angiogenic genes on real-time reverse transcriptase polymerase chain reaction. Peripheral neuropathy was induced by crushing the sciatic nerve with a hemostat, and CD31+ cells were then injected intramuscularly along the sciatic nerve. CD31+ cell transplantation restored motor nerve conduction velocity and voltage amplitude and improved motor coordination. In addition, CD31+ cell...
Source: Molecular and Cellular Neuroscience - November 3, 2014 Category: Neuroscience Source Type: research

Efficacy of hemostatic matrix and microporous polysaccharide hemospheres
Microporous Polysaccharide Hemospheres (MPH) are a new plant-derived polysaccharide powder hemostat. Previous studies investigated MPH as a replacement to nonflowable hemostatic agents of different application techniques (e.g., oxidized cellulose, collagen); therefore, the purpose of this study was to determine if MPH is a surrogate for flowable hemostatic agents of similar handling and application techniques, specifically a flowable thrombin-gelatin hemostatic matrix.
Source: Journal of Surgical Research - August 22, 2014 Category: Surgery Authors: Kevin M. Lewis, Holly Atlee, Angela Mannone, Lawrence Lin, Andreas Goppelt Source Type: research