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The LITFL Review 095
Welcome to the challenging 95th edition! The LITFL Review is your regular and reliable source for the highest highlights, sneakiest sneak peaks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the best and brightest from the blogosphere, the podcast video/audiosphere and the rest of the Web 2.0 social media jungle to find the most fantastic EM/CC FOAM (Free Open Access Meducation) around. The Most Fair Dinkum Ripper Beaut of the Week emimdoc Top spot this week heads over to David at emimdoc with his post on A Note to Conference Organiz...
Source: Life in the Fast Lane - February 18, 2013 Category: Emergency Medicine Doctors Authors: Kane Guthrie Tags: Education eLearning Emergency Medicine Featured Health Intensive Care LITFL review LITFL R/V Source Type: blogs

Precision Medicine and the Reinvention of Human Disease (Book Index)
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book ' s index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 198, 220geAcq...
Source: Specified Life - January 23, 2018 Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs

Thalidomide - The Real Story & The First Seal Baby By James Linder Jones, M.D., M.H.A., FACEP
http://www.healthworldnet.com/articles/the-best-of-the-best/the-first-seal-baby-the-real-story-of-thalidomide.htmlThalidomide, despite its sordid past is undergoing a sort of renaissance and is being manufactured and used worldwide for a variety of illnesses including leprosyThe Thalidomide story had a complex course, full of unintended discoveries, with unforeseen consequences including the elements of an adventure story; heroes and heroines, bad guys, villains, intrigue, deception, antagonists and protagonists, even Nazis.It was December 25, 1956. In Stollberg, Germany. A young, nervous, to-be Dad was waiting for news fr...
Source: PharmaGossip - May 20, 2013 Category: Pharma Commentators Authors: insider Source Type: blogs

Measuring What Matters In Primary Care
Editor’s Note: This is one of several posts Health Affairs Blog is publishing stemming from sessions at the June 2015 AcademyHealth Annual Research Meeting (ARM) in Minneapolis. What Do We Mean By ‘Primary Care’ Numerous studies have confirmed the central role of excellent primary care to any health system. Yet how to define the presence of excellent primary care remains a challenge. A recent review found that five characteristics remain the “sine qua non” for primary care practice: Accessible (first contact) care Continuous care Comprehensive care Coordinated care Accountable/whole-person care. Each individual...
Source: Health Affairs Blog - October 6, 2015 Category: Health Management Authors: Eugene Rich and Ann O’Malley Tags: Costs and Spending Featured Health Professionals Hospitals Medicare Organization and Delivery Population Health Quality AcademyHealth 2015 ARM Access chronic conditions clinician productivity comprehensive care continuous care Source Type: blogs

“ Crystal structure reveals how curcumin impairs cancer ”
Wow, VERY EXCITING BIT OF NEWS that popped up in my Google Alerts yesterday. My post title is the title of a new study revealing a previously unreported biochemical activity of curcumin. This very important study, carried out by three research teams (University of California San Diego School of Medicine, Peking University, and Zhejiang University), shows how curcumin attaches to, and INHIBITS, a gene called DYRK2, which is associated with cellular growth and/or development. This inhibition diminishes the proliferation of cancer cells. It reduces the tumor burden.  How about THAT? Here’s the link to the University ...
Source: Margaret's Corner - July 11, 2018 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll Crystal Structure Reveals How Curcumin Impairs Cancer University of California San Diego School of Medicine Source Type: blogs

Antitrust Lawsuit Against Celgene Over Thalomid and Revlimid Focuses on REMS Requirements
Celgene's successful cancer drugs Thalomid and Revlimid are at the center of an antitrust action. On April 3rd, Mylan Pharmaceuticals Inc. filed an antitrust lawsuit against Celgene Corporation in the U.S. District Court of New Jersey, accusing Celgene of blocking generic competition from Thalomid and Revlimid. Mylan accused Celgene of abusing their FDA Risk Evaluation and Mitigation Strategy requirements in order to monopolize the cancer drug market. As a background, in 2007, the Food and Drug Administration Amendments Act (FDAAA) gave FDA the authority to require a Risk Evaluation and Mitigation Strategy (REMS) from man...
Source: Policy and Medicine - August 14, 2014 Category: American Health Authors: Thomas Sullivan Source Type: blogs

Persuing ASCO 2017 - AKA Time for Lorazepam
Photo from ASCO Mediakit. © ASCO/Danny Morton 2017TheAnnual Meeting of the American Society of Clinical Oncology was last week. It ’s been my observation over the years that much of the best palliative-oncology and supportive-oncology research is presented at ASCO each year, before it’s actually published (if it ever gets published).  So I always dig through the palliative/EOL/supportive/psychooncology abstracts each year to see what ' s happening. Below is a gently annotated list of the abstracts that caught my eye the most, for your perusal and edification. Undoubtedly, these are my idiosyncratic choices, ...
Source: Pallimed: A Hospice and Palliative Medicine Blog - June 8, 2017 Category: Palliative Care Tags: ASCO cancer oncology pallonc research research issues rosielle WaPo Source Type: blogs

Fight Aging! Newsletter, June 21st 2021
This study showed that the leakage of this mitochondrial nucleic material may occur as a result of mitochondrial dysfunction, which may involve genetic mutations in genes encoding mitochondrial proteins or incomplete degradation of mitochondrial dsDNA in the lysosome - which is a 'degradation factory' of the cell. Upon the leakage into the cytoplasm, this undegraded dsDNA is detected by a 'foreign' DNA sensor of the cytoplasm (IFI16) which then triggers the upregulation of mRNAs encoding for inflammatory proteins." Using a PD zebrafish model (gba mutant), the researchers demonstrated that a combination of PD-like ph...
Source: Fight Aging! - June 20, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Exercise as part of cancer treatment
In a first, a national cancer organization has issued formal guidelines recommending exercise as part of cancer treatment, for all cancer patients. The Clinical Oncology Society of Australia (COSA) is very clear on the directive. Its recommendations are: Exercise should be embedded as part of standard practice in cancer care and viewed as an adjunct therapy that helps counteract the adverse effects of cancer and its treatment. All members of the multi-disciplinary cancer team should promote physical activity and help their patients adhere to exercise guidelines. Best practice cancer care should include referral to an accr...
Source: Harvard Health Blog - June 13, 2018 Category: Consumer Health News Authors: Monique Tello, MD, MPH Tags: Cancer Exercise and Fitness Health Source Type: blogs

Rising Cost Of Drugs: Where Do We Go From Here?
The trends are clear: patients and institutions across the nation are concerned about skyrocketing drug prices. This post offers some information about drug pricing, explores the notion of market intervention, and proposes a series of responses to high pharmaceutical costs. A few jaw-dropping facts quickly illustrate the pattern of rising drug costs. The average annual cost of cancer drugs increased from roughly $10,000 before 2000 to over $100,000 by 2012, according to a recent study in Mayo Clinic Proceedings. Several breakthrough specialty medications and orphan drugs recently approved by the Food and Drug Administratio...
Source: Health Affairs Blog - August 31, 2015 Category: Health Management Authors: Ifrad Islam Tags: Costs and Spending Drugs and Medical Technology Featured Medicaid and CHIP Payment Policy Public Health Big Pharma CMS FDA Gilead Sciences hepatitis C Pricewaterhouse Coopers Source Type: blogs

Pandemic Fears: What the AIDS Battle Should Teach Us About COVID-19
By ANISH KOKA, MD As the globe faces a novel, highly transmissible, lethal virus, I am most struck by a medicine cabinet that is embarrassingly empty for doctors in this battle.  This means much of the debate centers on mitigation of spread of the virus.  Tempers flare over discussions on travel bans, social distancing, and self quarantines, yet the inescapable fact remains that the medical community can do little more than support the varying fractions of patients who progress from mild to severe and life threatening disease.  This isn’t meant to minimize the massive efforts brought to bear to keep pat...
Source: The Health Care Blog - March 12, 2020 Category: Consumer Health News Authors: Christina Liu Tags: CORVID-19 Health Policy Patients Physicians AIDS Anish Koka AZT coronavirus COVID-19 FDA novel coronavirus Pandemic Source Type: blogs

News flash (!!!): long term use of curcumin in two smoldering multiple myeloma patients…
My blog’s title refers to a case report recently published in the Journal of Hematological Malignancies. The authors are the same researchers involved in the “famous” (well, famous to me, anyway! ) MGUS-curcumin randomized, double-blind placebo-controlled cross-over study in Australia. This is their second curcumin study. This time, it involves two smoldering myeloma patients, two men, [...]
Source: Margaret's Corner - February 26, 2013 Category: Cancer Authors: Margaret Tags: Blogroll Source Type: blogs

“ Use of curcumin in multiple myeloma patients intolerant of steroid therapy ”
Conclusion”). The other 12 patients, however, are stable and doing well, in spite of the fact that some have high-risk cytogenetic and FISH abnormalities. The combination of curcumin and the other conventional drugs reduced their paraprotein levels by 38%, and plasmacytosis by 59%. How about that? Anyway, it’s not a difficult read, methinks, so please have a look at the above link… Thank you, Dr. Golombick! I am so grateful to you and your team for all your tireless work. You give us hope!!! :-) Thank You Thank You Thank You!!! We need MORE studies like this one! Not 10 years from now…but…NOW!!!!!!!!!! 
Source: Margaret's Corner - February 28, 2020 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll curcumin Golombick myeloma Source Type: blogs

Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules. MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/ Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, prod...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs