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The effect of BCG vaccination on infection and antibody levels against SARS-CoV-2 – The results of ProBCG: A Multicenter Randomized Clinical Trial in Brazil
At the beginning of the Coronavirus Disease (COVID-19) pandemic [1], caused by severe acute respiratory syndrome Coronavirus (SARS-CoV-2), medical and scientific groups suggested using existing licensed vaccines or drugs to prevent and treat SARS-CoV-2 infection. Without approved, safe, and effective therapeutic options, these efforts could help mitigate the spread, morbidity, mortality, and economic losses consequent to the lethal virus [2].
Source: International Journal of Infectious Diseases - February 23, 2023 Category: Infectious Diseases Authors: Ana Paula Santos, Guilherme Loureiro Werneck, Ana Paula Razal Dalvi, Carla Concei ção dos Santos, Paulo Fernando Guimarães Morando Marzocchi Tierno, Hanna Silva Condelo, Bruna Macedo, Janaina Aparecida de Medeiros Leung, Jeane de Souza Nogueira, Ludmil Tags: Original article - Clinical Trial Source Type: research

Efficacy of Bacillus Calmette –Guérin (BCG) Vaccination in Reducing the Incidence and Severity of COVID-19 in High-Risk Population (BRIC): a Phase III, Multi-centre, Quadruple-Blind Randomised Control Trial
ConclusionsBCG is protective in reducing the incidence of acute respiratory illness (probable symptomatic COVID-19 infection) and severity of the disease, including hospitalisation, in patients belonging to the high-risk group of COVID-19 infection, and the antibody response persists for quite a long time. A multi-centre study with a larger sample size will help to confirm the findings in this study.Clinical Trials RegistryClinical Trials Registry India (CTRI/2020/07/026668).
Source: Infectious Diseases and Therapy - October 15, 2022 Category: Infectious Diseases Source Type: research

Worldwide inverse correlation between Bacille Calmette –Guérin (BCG) immunization and COVID-19 mortality
ConclusionThis study contributes to a growing body of evidence supporting the notion that BCG vaccination may be protective against COVID-19 mortality.
Source: Infection - January 25, 2021 Category: Infectious Diseases Source Type: research

Vaccination against tuberculosis can reduce the spread of COVID-19 and ease its course
(St. Petersburg State University) St Petersburg University scientists have analysed about 100 academic papers and statistics on the incidence of COVID-19 in different countries of the world. Analysis of these data showed that the spread of the new coronavirus infection occurs more slowly where there is a large percentage of people vaccinated against tuberculosis with the BCG vaccine. Moreover, this vaccination itself, given in early childhood, changes the immune system in such a way that the new coronavirus disease course tends to be less severe.
Source: EurekAlert! - Infectious and Emerging Diseases - December 3, 2020 Category: Infectious Diseases Source Type: news

Study: TB vaccine linked to lower risk of contracting COVID-19
(Cedars-Sinai Medical Center) A widely used tuberculosis vaccine is associated with reduced likelihood of contracting COVID-19 (coronavirus), according to a new study by Cedars-Sinai. The findings raise the possibility that a vaccine already approved by the U.S. Food and Drug Administration may help prevent coronavirus infections or reduce severity of the disease.
Source: EurekAlert! - Infectious and Emerging Diseases - November 20, 2020 Category: Infectious Diseases Source Type: news

BCG vaccine, a ray of hope in treating Severe Acute Respiratory Syndrome (SARS).
Abstract In December 2019 in Wuhan, China, the Severe Acute Respiratory Syndrome - Corona Virus - 2 (SARS-CoV-2) (also 2019 nCoV) was first discovered. Later WHO declared that SARS-CoV-2 was responsible for Coronavirus Disease 2019 (COVID-19). The round, elliptical or pleomorphic shape of the 2019-nCoV is 60-140 nm in diameter. It comprises a single stranded genome of RNA that comprises 29891 nucleotides, a lipid shell and spike protein, envelops membrane, and hemagglutinin-esterase (HE) proteins. Several therapeutic approaches have been proposed to combat with this disease as this disease became global pandemic. ...
Source: Infectious Disorders Drug Targets - October 16, 2020 Category: Infectious Diseases Authors: Banerjee AB, Singh TG, Prashar A Tags: Infect Disord Drug Targets Source Type: research

Impact of routine infant BCG vaccination in young generation on prevention of local COVID-19 spread in Japan
In Japan, the first case of coronavirus disease 2019 (COVID-19) was diagnosed in Kanagawa Prefecture on January 15, 2020.1 Because of an explosive increase in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections since late March, the Japanese Prime Minister declared a state of emergency for seven prefectures on April 7 and for the whole country on April 16. Japan lifted its nationwide state of emergency on May 25, 2020. The cumulative number of COVID-19 cases in Japan had topped 16,623 (13.1 per 100,000 population) on that date; however, this figure was much lower than that in Western countries.
Source: Journal of Infection - August 10, 2020 Category: Infectious Diseases Authors: Masako Kinoshita, Masami Tanaka Source Type: research

Impact of Routine Infant BCG Vaccination on COVID-19
In Japan, the first case of coronavirus disease 2019 (COVID-19) was diagnosed in Kanagawa Prefecture on January 15, 2020.1 Because of an explosive increase in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections since late March, the Japanese Prime Minister declared a state of emergency for seven prefectures on April 7 and for the whole country on April 16. Japan lifted its nationwide state of emergency on May 25, 2020. The cumulative number of COVID-19 cases in Japan had topped 16,623 (13.1 per 100,000 population) on that date; however, this figure was much lower than that in Western countries.
Source: Journal of Infection - August 10, 2020 Category: Infectious Diseases Authors: Masako Kinoshita, Masami Tanaka Source Type: research

Africa: Could BCG, a 100-Year-Old Vaccine for Tuberculosis, Protect Against Coronavirus?
[IPS] This week, the Bill and Melinda Gates Foundation announced it will donate A$10 million to help fund an Australian trial testing whether a very old vaccine, BCG, can be used against a new threat, COVID-19. So what is the BCG vaccine and what might its place be in the fight against coronavirus?
Source: AllAfrica News: Tuberculosis - May 15, 2020 Category: Infectious Diseases Source Type: news