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Outcome of COVID-19 and tolerance of Remdesivir in patients with renal failure: a single center experience from Pakistan
Conclusions: COVID-19 in renal failure has a high risk for ICU admissions leading to increased mortality. Multiple comorbidities and raised inflammatory markers are predictors of poor outcomes. We observed no significant drug-related adverse effects, and none of our patients required discontinuation of RDV due to worsening renal function.
Source: The Journal of Infection in Developing Countries - June 29, 2023 Category: Infectious Diseases Authors: Zaheer Udin Babar, Sunil Kumar Dodani, Asma Nasim, Jawahar Lal Langhani, Sanjay Kumar Badlani Source Type: research

Formulation Optimization and Evaluation of Nanocochleate Gel of Famciclovir for the Treatment of Herpes Zoster
CONCLUSION: A novel nanocochleate gel of Famciclovir was successfully developed for the treatment of infections associated with Herpes Zoster with sustained release action.PMID:35733311 | DOI:10.2174/1872210516666220622115553
Source: Herpes - June 23, 2022 Category: Infectious Diseases Authors: Rahul Sharma Ashwini Deshpande Abhishek Kanugo Source Type: research

SARS-CoV-2 infection in chronic kidney disease patients with pre-existing dialysis: description across different pandemic intervals and effect on disease course (mortality)
ConclusionsIn the present multicentre German cohort, dialysis dependency is not linked to fatal outcome in SARS-CoV-2-infected CKD patients. However, the mortality rate of 26% demonstrates that CKD patients are an extreme vulnerable population, irrespective of pre-existing dialysis-dependency.
Source: Infection - April 29, 2022 Category: Infectious Diseases Source Type: research

SARS-CoV2 Antibody Response After a Third Dose of Heterologous ChAdOx1 nCoV-19 and Moderna Vaccine in Chronic Dialysis Patients
The battle against coronavirus disease 2019 (COVID-19) remains the biggest challenge in controlling the spread of the disease globally. In this Journal, the report by Li and colleagues highlighted the danger to renal dialysis patients in the COVID-19 pandemic (1). Using the whole-genome sequencing and epidemiological data, the author demonstrated that the risk of SARS-CoV-2 transmission was present in the community and the hospital setting. Among various strategies against the spread of infection, current evidence indicates that vaccines continue to offer substantial protection against COVID-19.
Source: Journal of Infection - April 7, 2022 Category: Infectious Diseases Authors: Chung-Yi Cheng, Shih-Hsin Hsiao, Te-Chao Fang, Yen-Chung Lin, Jude Chu-Chun Wang, Ching-Sheng Hung, Tso-Hsiao Chen, Yuh-Mou Sue Tags: Letter to the Editor Source Type: research

Diminishing Immune Responses against Variants of Concern in Dialysis Patients 4 Months after SARS-CoV-2 mRNA Vaccination
Emerg Infect Dis. 2022 Feb 24;28(4). doi: 10.3201/eid2804.211907. Online ahead of print.ABSTRACTPatients undergoing chronic hemodialysis were among the first to receive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations because of their increased risk for severe coronavirus disease and high case-fatality rates. By using a previously reported cohort from Germany of at-risk hemodialysis patients and healthy donors, where antibody responses were examined 3 weeks after the second vaccination, we assessed systemic cellular and humoral immune responses in serum and saliva 4 months after vaccination with th...
Source: Emerging Infectious Diseases - February 24, 2022 Category: Infectious Diseases Authors: Alex Dulovic Monika Strengert Gema Morillas Ramos Matthias Becker Johanna Griesbaum Daniel Junker Karsten L ürken Andrea Beigel Eike Wrenger Gerhard Lonnemann Anne Cossmann Metodi V Stankov Alexandra Dopfer-Jablonka Philipp D Kaiser Bjoern Traenkle Ulric Source Type: research

Clinical profile, management and outcome of patients with leptospirosis during the times of COVID-19 pandemic: A prospective study from a tertiary care centre in South India
This study aimed to describe the clinical profile, management strategies and outcome of patients with leptospirosis amidst the Coronavirus disease-2019 outbreak. A prospective study of adult patients with undifferentiated fever (5-15 days) was conducted in South India between October 2020 and February 2021. The demographic, clinical details, laboratory details, treatment and outcome of leptospirosis positive (based on serology) and negative patients were compared. A chisquare test was used for qualitative variables, while an independent t-test or Mann Whitney U test was used for continuous variables. Of the 206 patients wi...
Source: Infezioni in Medicina - February 11, 2022 Category: Infectious Diseases Authors: Nitin Gupta William Wilson Prithvishree Ravindra Sowmya Joylin Rachana Bhat Kavitha Saravu Source Type: research

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