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COVID-19 Data Analytics Using Extended Convolutional Technique
Interdiscip Perspect Infect Dis. 2022 Nov 7;2022:4578838. doi: 10.1155/2022/4578838. eCollection 2022.ABSTRACTThe healthcare system, lifestyle, industrial growth, economy, and livelihood of human beings worldwide were affected due to the triggered global pandemic by the COVID-19 virus that originated and was first reported in Wuhan city, Republic Country of China. COVID cases are difficult to predict and detect in their early stages, and their spread and mortality are uncontrollable. The reverse transcription polymerase chain reaction (RT-PCR) is still the first and foremost diagnostical methodology accepted worldwide; hen...
Source: Interdisciplinary Perspectives on Infectious Diseases - November 17, 2022 Category: Infectious Diseases Authors: Anand Kumar Gupta Asadi Srinivasulu Olutayo Oyeyemi Oyerinde Giovanni Pau C V Ravikumar Source Type: research
Biomimetic lung-on-a-chip to model virus infection and drug evaluation
Eur J Pharm Sci. 2022 Nov 11:106329. doi: 10.1016/j.ejps.2022.106329. Online ahead of print.ABSTRACTViral infectious diseases remain a global public health problem. The rapid and widespread spread of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2) has had a severe impact on the global economy and human activities, highlighting the vulnerability of humans to viral infectious diseases and the urgent need to develop new technologies and effective treatments. Organ-on-a-chip is an emerging technology for constructing the physiological and pathological microenvironmen...
Source: European Journal of Pharmaceutical Sciences - November 14, 2022 Category: Drugs & Pharmacology Authors: Jianfeng Tan Quanwei Guo Lingling Tian Zhendong Pei Dongfang Li Mengxi Wu Jianhua Zhang Xinghua Gao Source Type: research
The Value of Rotavirus Vaccination in Europe: A Call for Action
AbstractThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has pushed many healthcare systems into crisis. High vaccine coverage amongst children reduces emergency room presentations, hospital admissions and deaths due to vaccine-preventable diseases, freeing up healthcare resources including polymerase chain reaction testing for p atients with SARS-CoV-2. In Europe, rotavirus gastroenteritis leads to 75,000–150,000 hospitalisations and up to 600,000 medical encounters annually. Nevertheless, in 2022, only 18 countries in Europe (out of 38) have a publicly funded routine universal mass immunisati...
Source: Infectious Diseases and Therapy - November 10, 2022 Category: Infectious Diseases Source Type: research
SARS-CoV-2 tetrameric RBD protein blocks viral infection and induces potent neutralizing antibody response
The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed serious threats to global health and economy and calls for the development of safe treatments and effective vaccines. The receptor-binding domain in the spike protein (SRBD) of SARS-CoV-2 is responsible for its binding to angiotensin-converting enzyme 2 (ACE2) receptor. It contains multiple dominant neutralizing epitopes and serves as an important antigen for the development of COVID-19 vaccines. Here, we showed that dimeric SRBD-Fc and tetrameric 2xSRBD-Fc fusion proteins bind ACE2 with diff...
Source: Frontiers in Immunology - October 31, 2022 Category: Allergy & Immunology Source Type: research
IJERPH, Vol. 19, Pages 13956: Trade-Off between COVID-19 Pandemic Prevention and Control and Economic Stimulus
obo Xie
The coronavirus disease 2019 (COVID-19) pandemic has posed a severe threat to public health and economic activity. Governments all around the world have taken positive measures to, on the one hand, contain the epidemic spread and, on the other hand, stimulate the economy. Without question, tightened anti-epidemic policy measures restrain people’s mobility and deteriorate the levels of social and economic activity. Meanwhile, loose policy measures bring little harm to the economy temporarily but could accelerate the transmission of the virus and ultimately wreck social and economic development. The...
Source: International Journal of Environmental Research and Public Health - October 27, 2022 Category: Environmental Health Authors: Fangfang Liu Zheng Ma Ziqing Wang Shaobo Xie Tags: Article Source Type: research
Viruses, Vol. 14, Pages 2324: An Update on Detection Technologies for SARS-CoV-2 Variants of Concern
Guangcai Duan
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is responsible for the global epidemic of Coronavirus Disease 2019 (COVID-19), with a significant impact on the global economy and human safety. Reverse transcription-quantitative polymerase chain reaction (RT-PCR) is the gold standard for detecting SARS-CoV-2, but because the virus’s genome is prone to mutations, the effectiveness of vaccines and the sensitivity of detection methods are declining. Variants of concern (VOCs) include Alpha, Beta, Gamma, Delta, and Omicron, which are able to evade recognition by host immune mechanism...
Source: Viruses - October 22, 2022 Category: Virology Authors: Wenjie Jiang Wangquan Ji Yu Zhang Yaqi Xie Shuaiyin Chen Yuefei Jin Guangcai Duan Tags: Review Source Type: research
News at a glance: Climate justice, ethical mask wearers, and CDC under Trump
The objective was to learn whether the protein alone explains Omicron’s lower pathogenicity.
The hybrid virus killed 80% of infected mice
, according to a preprint posted on 14 October by Boston University (BU) researchers. Critics worried it could escape the lab. They also argued that the work, partially funded by the National Institutes of Health (NIH), qualifies as “gain-of-function” (GOF) research that makes risky pathogens more dangerous and should have gone through a high-level federal review (
see feature
). BU officials said the study, conducted under the second highest level of biosafety precau...
Source: Science of Aging Knowledge Environment - October 20, 2022 Category: Geriatrics Source Type: research
IJERPH, Vol. 19, Pages 13476: Exploring Public Discussions Regarding COVID-19 Vaccinations on Microblogs in China: Findings from Machine Learning Algorithms
This study employed machine learning methods in the field of artificial intelligence to analyze mass data obtained from SinaWeibo. A total of 1,478,875 valid microblog texts were collected between December 2020 and June 2022, the results of which indicated that: (1) overall, negative texts (38.7%) slightly outweighed positive texts (36.1%); “Good” (63%) dominated positive texts, while “disgust” (44.6%) and “fear” (35.8%) dominated negative texts; (2) six overarching themes related to COVID-19 vaccination were identified: public trust in the...
Source: International Journal of Environmental Research and Public Health - October 18, 2022 Category: Environmental Health Authors: Qiong Dang Shixian Li Tags: Article Source Type: research
Viruses, Vol. 14, Pages 2271: Development of Single-Cell Transcriptomics and Its Application in COVID-19
This article reviewed the use of single-cell transcriptomics in COVID-19 research, examined the immune response disparities generated by SARS-CoV-2, and offered insights regarding how to improve COVID-19 diagnosis and treatment plans.
Source: Viruses - October 16, 2022 Category: Virology Authors: Chaochao Wang Ting Huyan Xiaojie Zhou Xuanshuo Zhang Suyang Duan Shan Gao Shanfeng Jiang Qi Li Tags: Review Source Type: research
Internet of Things (IoT) Adoption Model for Early Identification and Monitoring of COVID ‑19 Cases: A Systematic Review
Conclusions: The use of IoT along with advanced intelligence and computing technologies for ubiquitous monitoring and tracking of patients in quarantine has made it a critical aspect in fighting the spread of the current COVID ‑19 and even future pandemics.
Source: International Journal of Preventive Medicine - October 15, 2022 Category: International Medicine & Public Health Source Type: research
