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Viruses, Vol. 15, Pages 1933: Unraveling the Dynamics of Omicron (BA.1, BA.2, and BA.5) Waves and Emergence of the Deltacton Variant: Genomic Epidemiology of the SARS-CoV-2 Epidemic in Cyprus (Oct 2021 & ndash;Oct 2022)
This study offers a comprehensive assessment spanning genetic, phylogenetic, phylodynamic, and phylogeographic dimensions, focused on the trajectory of the SARS-CoV-2 epidemic in Cyprus. Based on a dataset comprising 4700 viral genomic sequences obtained from affected individuals between October 2021 and October 2022, our analysis is presented. Over this timeframe, a total of 167 distinct lineages and sublineages emerged, including variants such as Delta and Omicron (1, 2, and 5). Notably, during the fifth wave of infections, Omicron subvariants 1 and 2 gained prominence, followed by the ascendancy of Omicron 5 in the subs...
Source: Viruses - September 15, 2023 Category: Virology Authors: Andreas C. Chrysostomou Bram Vrancken Christos Haralambous Maria Alexandrou Ioanna Gregoriou Marios Ioannides Costakis Ioannou Olga Kalakouta Christos Karagiannis Markella Marcou Christina Masia Michail Mendris Panagiotis Papastergiou Philippos C. Patsali Tags: Article Source Type: research
Metabolism Pathways of Major Therapeutics for Treating Monkeypox Mono- and Co-infection with Human Immunodeficient Virus or SARS-CoV-2
Curr Drug Metab. 2023 Jun 7. doi: 10.2174/1389200224666230607124102. Online ahead of print.ABSTRACTMonkeypox is a zoonotic viral disease and remains endemic in tropical regions of Central and West Africa. Since May of 2022, cases of monkeypox have soared and spread worldwide. Confirmed cases have shown no travel history to the endemic regions as seen in the past. The World Health Organization declared monkeypox a global public health emergency in July 2022, and the United States government followed suit one month later. The current outbreak, in contrast to traditional epidemics, has high coinfection rates, particularly wit...
Source: Current Drug Metabolism - June 8, 2023 Category: Drugs & Pharmacology Authors: Daisy Yan Bingfang Yan Source Type: research
‘It’s still killing and it’s still changing.’ Ending COVID-19 states of emergency sparks debate
The World Health Organization (WHO) today declared an end to the emergency phase of the COVID-19 pandemic, days ahead of when a similar emergency in the United States is also set to expire. Both moves are likely to usher the world into a new phase of disease monitoring with a scaling back of surveillance and available resources to fight COVID-19.
WHO’s director-general, Tedros Adhanom Ghebreyesus, said at a press conference today in Geneva that WHO’s emergency committee met yesterday and recommended ending the Public Health Emergency of International Concern (PHEIC), the highest alert level WHO can declare, that h...
Source: Science of Aging Knowledge Environment - May 5, 2023 Category: Geriatrics Source Type: research
'It ’s still killing and it’s still changing.' Ending COVID-19 states of emergency sparks debate
The World Health Organization (WHO) today declared an end to the emergency phase of the COVID-19 pandemic, days ahead of when a similar emergency in the United States is also set to expire. Both moves are likely to usher the world into a new phase of disease monitoring with a scaling back of surveillance and available resources to fight COVID-19.
WHO’s director-general, Tedros Adhanom Ghebreyesus, said at a press conference today in Geneva that WHO’s emergency committee met yesterday and recommended ending the Public Health Emergency of International Concern (PHEIC), the highest alert level WHO can declare, that h...
Source: Science of Aging Knowledge Environment - May 5, 2023 Category: Geriatrics Source Type: research
Pandemic emergencies grind to a halt
The World Health Organization (WHO) today declared an end to the emergency phase of the COVID-19 pandemic, days ahead of when a similar emergency in the United States is also set to expire. Both moves are likely to usher the world into a new phase of disease monitoring with a scaling back of surveillance and available resources to fight COVID-19.
WHO’s director-general, Tedros Adhanom Ghebreyesus, said at a press conference today in Geneva that WHO’s emergency committee met yesterday and recommended ending the Public Health Emergency of International Concern (PHEIC), the highest alert level WHO can declare, that h...
Source: ScienceNOW - May 5, 2023 Category: Science Source Type: news
The ‘invented persona’ behind a key pandemic database
When Jeremy Kamil started to sequence samples of the rapidly spreading pandemic coronavirus in the spring of 2020, it was clear where he should deposit the genetic data: in
GISAID
, a long-running database for influenza genomes that had established itself as the go-to repository for SARS-CoV-2 as well.
Kamil, a virologist at Louisiana State University’s (LSU’s) Health Sciences Center Shreveport, says he quickly struck up a friendly relationship with a Steven Meyers, who used a gisaid.org email address. The two often exchanged emails and talked on the phone, sometimes for hours, about the pandemic and data sh...
Source: ScienceNOW - April 19, 2023 Category: Science Source Type: news
What Can We Still Learn from Brain Autopsies in COVID-19?
Semin Neurol DOI: 10.1055/s-0043-1767716Neuropathological findings have been published from ∼900 patients who died with or from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, representing less than 0.01% of the close to 6.4 million deaths reported to the World Health Organization 2 years into the coronavirus disease 2019 (COVID-19) pandemic. In this review, we extend our prior work summarizing COVID-19 neuropathology by including information on published autopsies up to June 2022, and neuropathological studies in children, COVID-19 variants, secondary brain infections, ex vivo brain imaging, and...
Source: Seminars in Neurology - April 6, 2023 Category: Neurology Authors: Solomon, Isaac H. Singh, Arjun Folkerth, Rebecca D. Mukerji, Shibani S. Tags: Review Article Source Type: research
Impact of In-hospital Statin Use on Mortality in COVID-19 Patients from a Majority African American Population
Coronavirus Disease 2019 (COVID-19) was declared a worldwide pandemic by the World Health Organization on March 11, 2020.1 As of August 18th, 2022, the pandemic has claimed over 6,400,000 lives worldwide and over 1,000,000 lives in the United States according to the Johns Hopkins Coronavirus Resource Center.2 The virus works primarily by binding to angiotensin-converting receptor 2 on alveolar epithelial cells, whereby it activates the innate and adaptive immune systems and results in inflammation caused by a pro-inflammatory cytokine storm.
Source: Heart and Lung - March 12, 2023 Category: Intensive Care Authors: Nitish Sood, Dhairya Shukla, Pranjal Mishra, Saloni Sharma, Sahil Gandhi, Daniel F. Linder, Priyank Shah Source Type: research
What We Know About the U.S. Intelligence Community ’ s Split on COVID-19 Origins
News that the U.S. Department of Energy made a determination about the origins of COVID-19 has sparked new questions about the U.S. intelligence community’s investigation of the global pandemic that has killed an estimated 6.85 million people.
The Energy Department, which runs multiple national laboratories, concluded with a low level of confidence that COVID-19 most likely emerged as a result of a leak from a laboratory in China, the Wall Street Journal reported on Sunday, citing anonymous sources. The Journal reported that the Energy Department’s new determination was classified. Previously, the agency was un...
Source: TIME: Health - February 28, 2023 Category: Consumer Health News Authors: Mini Racker Tags: Uncategorized COVID-19 Explainer National Security Source Type: news
President Joe Biden Announces COVID-19 National Emergencies Will End on May 11
WASHINGTON — President Joe Biden informed Congress on Monday that he will end the twin national emergencies for addressing COVID-19 on May 11, as most of the world has returned closer to normalcy nearly three years after they were first declared.
The move to end the national emergency and public health emergency declarations would formally restructure the federal coronavirus response to treat the virus as an endemic threat to public health that can be managed through agencies’ normal authorities.
Read More: COVID-19 Is No Longer a Public Health Emergency
It comes as lawmakers have already ended elements of the ...
Source: TIME: Health - January 31, 2023 Category: Consumer Health News Authors: Zeke Miller and Amanda Seitz / AP Tags: Uncategorized COVID-19 overnight wire Source Type: news
Roche launches COVID-19 PCR test to detect the fast spreading XBB.1.5 Omicron sub-variant
This new test for researchers specifically targets the XBB.1.5 Omicron sub-variant and runs on the real-time PCR platformsLightCycler® 480 II* andcobas® z480.Results from the test will help closely track the virus ’ lineage and provide insights into the epidemiology and impact it has on public health.Concern from the World HealthOrganisationcentres around the XBB.1.5 high transmissibility and growth advantage.1Basel, 26 January 2023 - Roche (SIX: RO, ROG; OTCQX: RHHBY) and its subsidiary TIB Molbiol have developed a COVID-19 PCR test for researchers that detects and differentiates the latest variant of concern, XBB.1.5...
Source: Roche Media News - January 26, 2023 Category: Pharmaceuticals Source Type: news
Health Experts Warily Eye XBB.1.5, the Latest Omicron Subvariant
A young version of the coronavirus makes up one-quarter of Covid cases across the United States and over 70 percent of new cases in the Northeast.
Source: NYT Health - January 7, 2023 Category: Consumer Health News Authors: Carl Zimmer Tags: Coronavirus (2019-nCoV) Coronavirus Omicron Variant Evolution (Biology) Viruses Proteins Antibodies Centers for Disease Control and Prevention GISAID (Nonprofit) World Health Organization Van Kerkhove, Maria China Northeastern States Source Type: news
China ’s Zero-COVID Trap
Protesters in China have demanded an end to the country’s draconian zero-COVID policy—a pandemic prevention strategy that President Xi Jinping claims has kept his people safer than less stringent measures taken by other nations—as the suffering it’s wrought is becoming increasingly unbearable.
Experts have said it’s unlikely the government will outright end zero-COVID anytime soon, though it may continue to tweak the policy. But even if Xi wanted to ditch the strategy altogether, as some localities are reportedly starting to do, that could bring about even more misery.
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Source: TIME: Health - December 1, 2022 Category: Consumer Health News Authors: Chad de Guzman and Amy Gunia Tags: Uncategorized China COVID-19 overnight Source Type: news
Roche receives FDA clearance for COVID-19 PCR test for use on cobas 6800/8800 Systems
Thecobas SARS-CoV-2 Qualitative test is one of the first COVID-19PCR tests performed on an automated, high throughput platform to receive FDA 510(k) clearance.This FDA clearance will ensure that the healthcare community has access to timely, reliable and accurate COVID-19 PCR testing beyond the EUA period.Based on continuous analysis performed since the onset of the pandemic, all Roche molecular tests, including thecobas SARS-CoV-2 Qualitative test, detect all SARS-CoV-2 variants.Basel, 24 October 2022 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the U.S. Food and Drug Administration (FDA) has granted 510(k) c...
Source: Roche Media News - October 24, 2022 Category: Pharmaceuticals Source Type: news
Evaluation of quality and antimicrobial efficacy of locally manufactured alcohol-based hand sanitizers marketed in Addis Ababa, Ethiopia in the era of COVID-19
ConclusionOne-third of the tested ABHS did not comply with the WHO ethanol content limit and the majority of the products failed to meet the label claim for hydrogen peroxide content. Besides, nearly all products proved that they have activity against all the tested pathogenic microorganisms at a minimum concentration from 10 to 80%; though, they did not show 99.9% bacteriostatic or bactericidal activities as claimed. The study findings suggested regular monitoring of the quality of marketed ABHS considering the current wide use of these products.
Source: Antimicrobial Resistance and Infection Control - October 8, 2022 Category: Infectious Diseases Source Type: research
