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Efficacy of three COVID-19 vaccine doses in lung transplant recipients: a multicentre cohort study
Conclusions Few lung transplant recipients achieved a serological response to three COVID-19 vaccine doses, indicating a need for other protective measures. Older age and use of mycophenolate or corticosteroids were associated with absence of a response. The low incidence of COVID-19 might reflect vaccine protection via cellular immunity and/or good adherence to shielding measures.
Source: European Respiratory Journal - January 19, 2023 Category: Respiratory Medicine Authors: Dauriat, G., Beaumont, L., Luong Nguyen, L. B., Renaud Picard, B., Penhouet, M., Coiffard, B., Salpin, M., Demant, X., Saint Raymond, C., Carlier, N., Messika, J., Reynaud Gaubert, M., Danner, I., Gallais, F., Roux, A., Le Pavec, J. Tags: Respiratory infections and tuberculosis Original Articles: Lung transplantation Source Type: research

Effects of the COVID-19 Pandemic on Solid Organ Transplantation During 2020 in Poland Compared with Countries in Western Europe, Asia, and North America: A Review
Med Sci Monit. 2021 Sep 4;27:e932025. doi: 10.12659/MSM.932025.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic, due to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which began in March 2020, affected organ donor acceptance and rates of heart, lung, kidney, and liver transplants worldwide. According to data reported to POLTRANSPLANT, the number of solid organ transplants decreased by over 35% and the number of patients enlisted de novo for organ transplantation was reduced to 70% of its pre-COVID-19 volume in Poland. Most transplant centers in Western Europe and the USA have also dra...
Source: Medical Science Monitor - September 4, 2021 Category: Research Authors: Magdalena Kwapisz Piotr Ma łkowski Olga Tronina Dariusz Wasiak Jaros ław Czerwiński Wojciech G Polak Maciej Kosieradzki Source Type: research

Solid Organ Transplantation in the Era of COVID-19: Lessons from France
Coronavirus disease 2019 (COVID-19) outbreak has significantly upended solid organ transplant (SOT) practice around the world. Early reports confirmed the heavy burden of COVID-19 in SOT recipients with mortality rates reaching up to 35%. Because most transplant recipients harbored multiple comorbidities known to be associated with a severe course of COVID-19, the true impact of immunosuppression by itself remained an unsolved issue. Transplant societies have initially recommended to postpone nonurgent renal transplantations, while trying to maintain life-saving transplant programs, such as heart, lung, and liver transplan...
Source: Transplantation - December 24, 2020 Category: Transplant Surgery Tags: Reviews Source Type: research

COVID-19 in Lung Transplant Recipients
Conclusions. For the 35 LT recipients with COVID-19, the presentation was severe, requiring hospitalization in most cases, with a survival rate of 85.7%.
Source: Transplantation - December 24, 2020 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

An initial report from the French SOT COVID Registry suggests high mortality due to Covid-19 in recipients of kidney transplants.
Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in recipients of a kidney transplant remain scanty. The aim of this registry-based observational study was to explore characteristics and clinical outcomes of recipients of kidney transplants included in the French nationwide Registry of Solid Organ Transplant Recipients with Covid-19. Covid-19 was diagnosed in symptomatic patients who had a positive PCR assay for SARS-CoV-2 or having typical lung lesions on imaging.
Source: Kidney International - August 22, 2020 Category: Urology & Nephrology Authors: Sophie Caillard, Dany Anglicheau, Marie Matignon, Antoine Durrbach, Clarisse Greze, Luc Frimat, Olivier Thaunat, Tristan Legris, Valerie Moal, Pierre Francois Westeel, Nassim Kamar, Philippe Gatault, Renaud Snanoudj, Antoine Sicard, Dominique Bertrand, Ch Tags: clinical investigation Source Type: research

Fight Aging! Newsletter, April 13th 2020
This study is par for the course, looking at Japanese Olympic participants. Interestingly, it hints at the upper end of the dose-response curve for physical activity, in that a longer career as a professional athlete may be detrimental in comparison to lesser degrees of exercise and training. From this large, retrospective cohort study targeting 3546 Japanese Olympic athletes, we observed significant lower mortality among Olympians compared with the Japanese general population. The overall standardised mortality ratio (SMR) was 0.29. The results were consistent with previous studies conducted in other non-Asian co...
Source: Fight Aging! - April 12, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs