The Future Of Vision And Eye Care
3D printed digital contact lenses, bionic eye implants, augmented reality: the future of vision and eye care is full of science fiction-sounding innovations. Here is where digital health will take ophthalmology in the future!
More than 80 percent of perception comes through vision
Researchers estimate that 80-85 percent of our perception, learning, cognition, and activities are mediated through vision. Compared to that, our hearing only processes 11 percent of information, while smell 3.5 percent, touch 1.5 percent and taste 1 percent. Don’t you think that’s possible? Renowned scholars, L.D. Ros...
Source: The Medical Futurist - May 10, 2022 Category: Information Technology Authors: berci.mesko Tags: Augmented Reality Cyborgization 3d printing AI diabetes digital digital health future guide Healthcare Innovation Personalized medicine technology vision eye care ophthalmology Source Type: blogs
Fight Aging! Newsletter, January 17th 2022
In conclusion, fibroblasts in monolayers cultured with soluble pentosidine and tridimensional in vitro skin constructs exposed to the combination of AGEs and UVA promote an inflammatory state and an alteration of the dermal compartment in relation to an elastosis-like environment. (Source: Fight Aging!)
Source: Fight Aging! - January 16, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, December 13th 2021
In conclusion, there is a good amount of pre-clinical and clinical data showing a strong positive correlation between reduction of senescent cells frequencies and functional improvement of skin. Whether senescence of skin cells makes a significant causal contribution to skin ageing can still not be conclusively decided, however. Nonetheless, there is strong evidence existing today to assume that better understanding of cell senescence in skin may lead to a breakthrough in interventions into skin ageing.
Isomerization of Tau May be Involved in Alzheimer's Disease
https://www.fightaging.org/archives/2021/12/isom...
Source: Fight Aging! - December 12, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Exercise Slows Retinal Aging, but Which of the Many Mechanisms Involved are Important?
As researchers note here, there is evidence for exercise to slow retinal aging and the progression of conditions involving retinal degeneration. Exercise affects many aspects of aging, not to the same degree as the practice of calorie restriction, but likely through an overlapping set of mechanisms related to cellular stress response upregulation, including increased autophagy and mitochondrial quality control. There is is a vast forest of interacting metabolic changes to explore, however, and the research community has yet to come to a solid grasp of which of the effects of exercise are the most relevant in any given tiss...
Source: Fight Aging! - December 10, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Eyevensys Electrotransfection System for Ocular Disease: Interview with Patricia Zilliox, CEO
Eyevensys, a medtech company based in France, has developed the Eyevensys Electrotransfection System, a non-viral transfection system for the treatment of ocular diseases. So far, the firm has demonstrated the safety of the technique in treating noninfectious uveitis and is developing treatments for geographic atrophy, retinitis pigmentosa, and wet age-related macular degeneration (AMD).
The technology delivers DNA plasmids to the ciliary muscle in the eye, leading to long-term production of proteins in the back of the eye for therapeutic benefit. The electricity is delivered in short pulses and helps to drive the genet...
Source: Medgadget - September 27, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Genetics Ophthalmology Source Type: blogs
Fight Aging! Newsletter, June 7th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 6, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Gene Therapy to Add a New Photosensitive Protein to the Retina
Researchers have delivered a non-human photosensitive protein to the retina of a patient long blind from the loss of photoreceptor cells caused by retinitis pigmentosa. The outcome as described is not as good as the results produced by implantation of grids of electrodes into the retina, but that strategy has been under development for a somewhat longer number of years. This approach is in the very early stages: it is unclear as to how well one can engineer the retina to use alternative means of translating light into signals to the optic nerve, and how well the brain will adapt to such new sources of information over time...
Source: Fight Aging! - June 1, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Electrodiagnosis of Ocular Diseases Using Sensor-Enabled Contacts
Electroretinography is a common technique for diagnosing and following up on eye conditions such as glaucoma, diabetic retinopathy, and retinitis pigmentosa. To perform an electroretinography exam, a device is placed against the eye that projects light onto it and measures the resulting electrical signals that are generated by the retina. Commercial electroretinography devices are rigid and require electrodes, often in the form of a hard contact lens, to touch the eye or the bulbar conjunctiva just underneath. This is irritating and unpleasant, and often requires general anesthesia or sedation to be administered, in additi...
Source: Medgadget - March 18, 2021 Category: Medical Devices Authors: Medgadget Editors Tags: Materials Ophthalmology Source Type: blogs
Wireless Brain Implant to Give Sight to Blind
Scientists in Australia are gearing up for clinical trials of a brain implant that may restore limited sight in blind people. Developed at Monash University in Melbourne, the Gennaris system involves bypassing the eye completely and targeting the vision center of the brain.
A person would wear a pair of glasses outfitted with a camera that, via a computer, feeds what it is seeing to the brain implant. The wireless implant is positioned on the surface of the brain and it can generate 172 different bright spots that the person can see. By properly producing these so-called phosphenes, it should be possible to provide ...
Source: Medgadget - September 25, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Neurology Neurosurgery Ophthalmology Rehab Source Type: blogs
Injectable Liquid Prosthesis to Treat Retinal Diseases Developed
Retinal prostheses promise the restoration of vision to people with age-related macular degeneration, retinitis pigmentosa, and other conditions that lead to the loss of functional photoreceptors. A number of technologies are already in existence that mimic the functionality of the retina by stimulating the inner retinal network, but most of these rely on wearable cameras, special glasses, computers, and wiring to interface with the eye. Moreover, the results are highly lacking and the achieved vision is extremely low resolution. At the IIT-Istituto Italiano di Tecnologia (Italian Institute of Technology), scientists have ...
Source: Medgadget - June 29, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Materials Ophthalmology Source Type: blogs
Fight Aging! Newsletter, June 15th 2020
In this study, we used markers to monitor the formation of SGs in Caenorhabditis elegans. We found that, in addition to acute heat stress, SG formation could also be triggered by dietary changes, such as starvation and dietary restriction (DR). We found that HSF-1 is required for the SG formation in response to acute heat shock and starvation but not DR, whereas the AMPK-eEF2K signaling is required for starvation and DR-induced SG formation but not heat shock. Moreover, our data suggest that this AMPK-eEF2K pathway-mediated SG formation is required for lifespan extension by DR, but dispensable for the longevity by reduced ...
Source: Fight Aging! - June 14, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Providing the Ability to See Near-Infrared Light as a Treatment for Retinal Degeneration
Researchers here propose an interesting approach to restoring vision in cases of age-related macular degeneration. They are using a gene therapy targeted at photoreceptor cells to provide these cells with the ability to be stimulated by near-infrared light. In tests in mice, this appears to function as intended, though it is always challenging to assess the quality of vision (as opposed to its presence or absence) in such experiments.
The main cause of blindness in industrialized countries is the degeneration of photoreceptors, including age-related macular degeneration and retinitis pigmentosa. During the progres...
Source: Fight Aging! - June 11, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Eyevensys Non-Viral Gene Therapy for Ocular Diseases: Interview with Patricia Zilliox, CEO of Eyevensys
Eyevensys, a clinical-stage biotechnology company based in France, has developed a method to perform non-viral gene therapy in the eye, with the aim of treating ocular diseases. The system uses ocular electrotransfection to deliver therapeutic genes into the eye. Consisting of an ocular device and an electrical pulse generator, the system can deliver DNA plasmids into the ciliary muscle. The idea is that the transfected cells in the eye allow for sustained local production of therapeutic proteins, which can then produce effects in a variety of structures in the eye, including the retina and choroid.
To date, the co...
Source: Medgadget - November 12, 2019 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Genetics Ophthalmology Source Type: blogs
Fight Aging! Newsletter, March 25th 2019
This study defines a new clinically relevant concept of T-cell senescence-mediated inflammatory responses in the pathophysiology of abnormal glucose homeostasis. We also found that T-cell senescence is associated with systemic inflammation and alters hepatic glucose homeostasis. The rational modulation of T-cell senescence would be a promising avenue for the treatment or prevention of diabetes.
Intron Retention via Alternative Splicing as a Signature of Aging
https://www.fightaging.org/archives/2019/03/intron-retention-via-alternative-splicing-as-a-signature-of-aging/
In recent years researchers have in...
Source: Fight Aging! - March 24, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Restoring Sight by Making Retinal Ganglion Cells Light Sensitive via Gene Therapy
Retinal degeneration causes blindness by destroying the photoreceptor cells in the retina. Some forms of degenerative blindness leave intact other cell populations, however. What if those populations could be granted some of the same mechanisms used by photoreceptor cells to pass signals to the optic nerve? Researchers here demonstrate a gene therapy that does just this, a most interesting feat of engineering. It is still a poor alternative to prevention of the condition, or restoration of lost photoreceptor cells, but it is no less impressive for it. This is truly an age of biotechnology.
Scientists inserted a ge...
Source: Fight Aging! - March 18, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
