Remote Physiotherapy to Protect Physical Health in Duchenne Muscular Dystrophy
Conditions: Duchenne Muscular Dystrophy Interventions: Other: Telerehabilitation Sponsors: Lokman Hekim Üniversitesi Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 26, 2023 Category: Research Source Type: clinical trials

Phase 2 Study of EDG-5506 in Children and Adolescents With Duchenne Muscular Dystrophy Previously Treated With Gene Therapy (FOX)
Conditions: Duchenne Muscular Dystrophy Interventions: Drug: EDG-5506 Dose 1; Drug: EDG-5506 Dose 2; Drug: Placebo Sponsors: Edgewise Therapeutics, Inc. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 25, 2023 Category: Research Source Type: clinical trials

Developing a Nationwide Registry to Track Longitudinal Clinical Outcomes of Corneal Surgery and Disease
Conditions: Corneal Disease; Endothelial Corneal Dystrophy; Corneal Transplant Failure; Corneal Transplant Rejection Interventions: Diagnostic Test: Optical Coherence Tomography Sponsors: Keratoplasty Alliance International Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 25, 2023 Category: Research Source Type: clinical trials

Comparative Effects of the Neurodynamic Slider and Tensioner Mobilisation Techniques on Sympathetic Nervous System Function: A Randomised Controlled Trial
Conditions: Health Care Acceptor Interventions: Other: Neurodynamic Sponsors: European University Cyprus Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 24, 2023 Category: Research Source Type: clinical trials

FSHD Molecular Characterization
Conditions: Facio-Scapulo-Humeral Dystrophy Sponsors: Nationwide Children ' s Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 23, 2023 Category: Research Source Type: clinical trials

Transcutaneous electrical vagus nerve stimulation to suppress premature ventricular complexes (TREAT PVC): study protocol for a multi-center, double-blind, randomized controlled trial
DiscussionThe present trial will be the first to evaluate the effect of LLTS on frequent PVCs on patients without SHD. LLTS may serve as a low-cost, minimal-risk, and non-invasive alternative to conventional antiarrhythmic therapy.Trial registrationClinicalTrial.gov NCT04909528. Registered on 17 June 2021. World health organization trial registration data set was shown in Supplementary Table1. (Source: Trials)
Source: Trials - October 23, 2023 Category: Research Source Type: clinical trials

Wearable Technology to Evaluate Hyperglycemia and HRV in DMD - Longitudinal Aim
Conditions: Duchenne Muscular Dystrophy Interventions: Device: wearable technology Sponsors: Vanderbilt University Medical Center Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 20, 2023 Category: Research Source Type: clinical trials

Initial Volume Status in Patients With Acute Brain Injury is Associated With Neurological Prognosis
Conditions: Acute Brain Injury; Paroxysmal Sympathetic Hyperactivity; Volume Status; Right Heart Function; Right Cardiogenic Pulmonary Edema; Glasgow Outcome Scale Extended Interventions: Other: Ultrasound evaluation Sponsors: Peking Union Medical College Hospital Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 19, 2023 Category: Research Source Type: clinical trials

Observational Study of Digital Biomarkers of Myotonia and Gait in Adults and Children With Myotonic Dystrophy
Conditions: Myotonic Dystrophy 1 Sponsors: Stanford University; Biogen Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 18, 2023 Category: Research Source Type: clinical trials

Comparing the effectiveness of extracorporeal shockwave therapy and myofascial release therapy in chronic pelvic pain syndrome: study protocol for a randomized controlled trial
DiscussionThis trial will compare the differences in efficacy between single extracorporeal shockwave therapy, single myofascial release therapy, and combined therapy to select the most appropriate treatment option for patients with CP/CPPS. The possible pathogenesis of CP/CPPS would also be analyzed by comparing the intercorrelation between each objective and subjective measurement (NIH-CPSI score, sEMG, SWE, SSR).Trial registrationThe name of the registry: Extracorporeal Shockwave and Myofascial Release Therapy in Chronic Pelvic Pain Syndrome.Registration number: NCT05659199.  Date of registration: December 2022. (Source: Trials)
Source: Trials - October 18, 2023 Category: Research Source Type: clinical trials

Unraveling Metabolic Involvement in Facioscapulohumeral Dystrophy Through Metabolomics
Conditions: Facioscapulohumeral Muscular Dystrophy Interventions: Other: metabolomic on plasma sample Sponsors: University Hospital, Angers; University of Modena and Reggio Emilia; Federico II University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 17, 2023 Category: Research Source Type: clinical trials

PepGen Inc. Announces FDA has Lifted the Clinical Hold on its Investigational New Drug Application for FREEDOM-DM1 Phase 1 Study of PGN-EDODM1 for Myotonic Dystrophy Type 1 (DM1)
Safety, transcript splicing and clinical outcome measures data at 5 mg/kg PGN-EDODM1 dose level in patients from FREEDOM-DM1 clinical study expected in 2024 Continue to expect safety, muscle exon skipping and dystrophin data at 5 mg/kg PGN-EDO51... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - October 12, 2023 Category: Pharmaceuticals Source Type: clinical trials

An 18-month Prospective Natural History Study to Gain Insight Into FSHD2 Pathophysiology and Disease Progression
Conditions: Facioscapulohumeral Muscular Dystrophy Type 2 Interventions: Diagnostic Test: Validation of new COMs for FSHD2 patients Sponsors: Centre Hospitalier Universitaire de Nice Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 12, 2023 Category: Research Source Type: clinical trials

A Study Of PGN-EDO51 In Participants With Duchene Muscular Dystrophy Amenable To Exon 51-Skipping Treatment
Conditions: Duchenne Muscular Dystrophy Interventions: Drug: PGN-EDO51 Sponsors: PepGen Inc Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 12, 2023 Category: Research Source Type: clinical trials

Cerebrospinal Fluid Biomarkers of Myotonic Dystrophy
Conditions: Myotonic Dystrophy Type 1 Sponsors: Massachusetts General Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 10, 2023 Category: Research Source Type: clinical trials