SBRT Versus Hypofractionated Radiotherapy for Biochemically Recurrent or Oligometastatic Prostate Adenocarcinoma
Conditions: Biochemically Recurrent Prostate Carcinoma; Oligometastatic Prostate Carcinoma; Recurrent Prostate Adenocarcinoma; Stage IIB Prostate Cancer AJCC v8; Stage IIC Prostate Cancer AJCC v8; Stage III Prostate Cancer AJCC v8; Stage IV Prostate Cancer AJCC v8 Interventions: Drug: Antiandrogen Therapy; Procedure: Biospecimen Collection; Procedure: Bone Scan; Radiation: Hypofractionated Radiation Therapy; Procedure: Magnetic Resonance Imaging; Procedure: Positron Emission Tomography; Radiation: Stereotactic Body Radiation Therapy; Other: Survey Administration Sponsors: Mayo Clinic Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 15, 2024 Category: Research Source Type: clinical trials
RCT on Intralesional Rituximab Injection Versus ISRT in Ocular Adnexal MALT Lymphoma
Conditions: Primary Ocular Adnexal MALT Lymphoma Interventions: Drug: Rituximab; Radiation: Involved Site Radiation Therapy Sponsors: Zhongshan Ophthalmic Center, Sun Yat-sen University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 4, 2024 Category: Research Source Type: clinical trials
HYPofractionated Adjuvant RadioTherapy in 1 versus 2 weeks in high-risk patients with breast cancer (HYPART): a non-inferiority, open-label, phase III randomised trial
In this study, we will compare a 1-week schedule of hypofractionated adjuvant whole breast/chest wall and/or regional nodal radiotherapy against 2 weeks for locoregional disease control, toxicities, quality of life (QoL), survival and second cancers after primary surgery in patients with breas t cancer.MethodsEligible patients with breast cancer after mastectomy or breast conserving surgery (BCS) will be treated with a radiotherapy dose of 26 Gy in 5 fractions over 1 week in the study arm and 34 Gy in 10 fractions over 2 weeks in the control arm. The primary endpoint of this noninferiority study will be locoregional tumour...
Source: Trials - January 2, 2024 Category: Research Source Type: clinical trials
Effect of Bra Use During Radiotherapy for Breast Cancer Radiotherapy
Conditions: Breast Cancer; Radiation Therapy Interventions: Device: Group wearing a radiotherapy bra Sponsors: Yonsei University Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 21, 2023 Category: Research Source Type: clinical trials
A Phase Ⅱ Clinical Study of Adebrelimab Combined With Chemotherapy and Concurrent Radiotherapy for Extensive-Stage Oligometastatic SCLC
Conditions: Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases; Carcinoma, Bronchogenic; Bronchial Neoplasms; Lung Neoplasms; Small Cell Lung Carcinoma Interventions: Drug: Adebrelimab; Drug: Carboplatin/Cisplatin; Drug: Etoposide; Radiation: Radiation therapy Sponsors: Nanfang Hospital, Southern Medical University; Suzhou Suncadia Biopharmaceuticals Co., Ltd. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 20, 2023 Category: Research Source Type: clinical trials
Induction of double-strand breaks with the non-steroidal androgen receptor ligand flutamide in patients on androgen suppression: a study protocol for a randomized, double-blind prospective trial
This study will confirm in humans the pharmacodynamic effect of AR ligands to induce transient double-strand breaks when administered in the context of androgen deprivation as a novel therapy for prostate cancer. The findings of this study will permit the development of a larger trial evaluating flutamide pulsed-dose sequencing in association with fractionated external beam RT (+/ − brachytherapy). The study is ongoing, and preliminary data collection and recruitment are underway; analysis has yet to be performed.Trial registrationClinicalTrials.gov NCT03507608. Prospectively registered on 25 April 2018. (Source: Trials)
Source: Trials - December 16, 2023 Category: Research Source Type: clinical trials
Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma
Conditions: Ganglioneuroblastoma; Neuroblastoma Interventions: Procedure: Biospecimen Collection; Procedure: Bone Marrow Aspiration; Procedure: Bone Marrow Biopsy; Procedure: Bone Scan; Drug: Carboplatin; Drug: Cisplatin; Procedure: Computed Tomography; Drug: Cyclophosphamide; Drug: Dexrazoxane; Biological: Dinutuximab; Drug: Doxorubicin; Drug: Etoposide; Procedure: FDG-Positron Emission Tomography and Computed Tomography Scan; Procedure: Hematopoietic Cell Transplantation; Drug: Irinotecan; Drug: Isotretinoin; Procedure: Leukapheresis; Procedure: Magnetic Resonance Imaging; Drug: Melphalan; Radiation: Radiation Therapy; O...
Source: ClinicalTrials.gov - December 15, 2023 Category: Research Source Type: clinical trials
Guided Meditation During Radiation Therapy for Brain Tumors
Conditions: Brain Neoplasms Interventions: Behavioral: 5-Minute, Audio-Recorded Guided Mediation Practice Sponsors: University of Utah Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 11, 2023 Category: Research Source Type: clinical trials
Retifanlimab With Bevacizumab and Hypofractionated Radiotherapy for the Treatment of Recurrent Glioblastoma
Conditions: Recurrent Glioblastoma; Recurrent WHO Grade 4 Glioma Interventions: Biological: Bevacizumab; Procedure: Biospecimen Collection; Procedure: Computed Tomography; Other: Electronic Health Record Review; Radiation: Hypofractionated Radiation Therapy; Procedure: Magnetic Resonance Imaging; Biological: Retifanlimab Sponsors: Academic and Community Cancer Research United; National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 7, 2023 Category: Research Source Type: clinical trials
Ventilation Using Radiographic Examination: Functional Lung Imaging Techniques for the Reduction of Toxicity in Functional Avoidance Radiation Therapy
Conditions: Lung Neoplasm Sponsors: University of Sydney; National Health and Medical Research Council, Australia; Northern Sydney and Central Coast Area Health Service Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 7, 2023 Category: Research Source Type: clinical trials
IMRT Versus 3DCRT for Locally Advanced Rectal Cancer, Prospective Phase II Study.
Conditions: Rectal Cancer; Radiotherapy; Toxicity Due to Radiotherapy Interventions: Radiation: Intensive Modulated Radiation Therapy; Radiation: 3-Dimension Conformal Radiation Therapy Sponsors: Rabin Medical Center Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 7, 2023 Category: Research Source Type: clinical trials
18F-FLUC-CEST PET/MR in Patients With Brain Mets
Conditions: Brain Metastasis; Radiation Therapy; Immunotherapy, Active Interventions: Radiation: F-Fluciclovine radiotracer Sponsors: University of Wisconsin, Madison; Blue Earth Diagnostics Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 6, 2023 Category: Research Source Type: clinical trials
A Study of Xevinapant With Cisplatin and Radiation Therapy After Surgery in People With Head and Neck Cancer
Conditions: Head and Neck Cancer Interventions: Drug: Xevinapan; Drug: Cisplatin; Radiation: External beam Sponsors: Memorial Sloan Kettering Cancer Center Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 24, 2023 Category: Research Source Type: clinical trials
A Pilot Study For Patients Receiving Radiation Therapy for Liver Cancer
Conditions: Cancer, Hepatocellular; Radiotherapy Side Effect Interventions: Device: Multiparametric MRI scans; Device: Multiparametric MRI scans + HepQuantShunt Test Sponsors: Montefiore Medical Center; HepQuant, LLC; Perspectum Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 22, 2023 Category: Research Source Type: clinical trials
Metastases Directed Therapy for Oligometastatic Breast Cancer
Conditions: Breast Cancer; Metastatic Cancer; Metastatic Breast Cancer Interventions: Radiation: Stereotactic Ablative Radiation Therapy; Procedure: Locoregional treatment; Other: Standard of Care Sponsors: National Cancer Institute, Egypt Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 22, 2023 Category: Research Source Type: clinical trials
