Efficacy of an aloe vera, chamomile, and thyme cosmetic cream for the prophylaxis and treatment of mild dermatitis induced by radiation therapy in breast cancer patients: a controlled clinical trial (Alantel Trials)
The objective was to evaluate the effect of a cream (Alantel) based on natural products at high concentrations for the preventive and cura tive treatment (at early stages) of radiation-induced dermatitis in patients with breast cancer.MethodsOur protocol is an experimental, prospective, triple-blind, multicenter, controlled clinical trial with two parallel arms. The experimental group will be treated with Alantel, while the control group will receive another moisturizing cream. Radiotherapy oncology professionals will recruit a total of 88 patients (44 per comparison group) with breast cancer who will receive radiotherapy ...
Source: Trials - January 25, 2024 Category: Research Source Type: clinical trials
Tumor-directed Radiation Therapy for Patients With the Highest Risk Category of Localized Prostate Cancer
Conditions: Prostate Cancer Interventions: Radiation: Ultra-hypofractionated radiotherapy regimen. Sponsors: Region Skane Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 24, 2024 Category: Research Source Type: clinical trials
Data Collection of Prepectoral Breast Reconstruction With Polyurethane Implantes
Conditions: Prepectoral Breast Reconstruction; Breast Reconstruction; Radiation Therapy Complication Interventions: Procedure: Prepectoral breast reconstruction with polyurethane implants Sponsors: European Institute of Oncology Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 22, 2024 Category: Research Source Type: clinical trials
High-Risk Metachronous Oligometastatic Prostate Cancer Trial
Conditions: Prostate Cancer; Oligometastatic Disease Interventions: Drug: niraparib/abiraterone acetate; Radiation: Stereotactic ablative radiation therapy (SABR); Drug: Androgen deprivation therapy (ADT) Sponsors: University of Maryland, Baltimore; Janssen Scientific Affairs, LLC Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 19, 2024 Category: Research Source Type: clinical trials
Radiation Therapy in Unresectable Gall Bladder Cancer
Conditions: Gall Bladder Cancer Interventions: Drug: Systemic therapy (Gemcitabine plus Cisplatin); Radiation: RT; Drug: Systemic therapy (Gemcitabine plus oxaliplatin); Drug: Systemic therapy (Gemcitabine plus Cisplatin plus Durvalumab); Drug: Systemic therapy (Gemcitabine plus cisplatin plus nab-paclitaxel) Sponsors: Tata Memorial Centre Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 19, 2024 Category: Research Source Type: clinical trials
Losartan, Pembrolizumab and Stereotactic Body Radiation Therapy for the Treatment of Patients With Locally Recurrent, Refractory or Oligometastatic Head and Neck Squamous Cell Carcinoma
Conditions: Locally Recurrent Head and Neck Squamous Cell Carcinoma; Metastatic Head and Neck Squamous Cell Carcinoma; Refractory Head and Neck Squamous Cell Carcinoma Interventions: Drug: Losartan; Biological: Pembrolizumab; Radiation: Stereotactic Body Radiation Therapy Sponsors: Shyam S.D. Rao; National Cancer Institute (NCI) Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 18, 2024 Category: Research Source Type: clinical trials
A Single-center Phase II Study to Investigate the Immune Maintenance Therapy Pattern in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Who Have Achieved MPR After Neoadjuvant Immunotherapy Combined With Chemotherapy
Conditions: Head and Neck Cancer Interventions: Drug: Toripalimab; Radiation: Radiation Therapy; Drug: Cisplatin Sponsors: Tianjin Medical University Cancer Institute and Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 17, 2024 Category: Research Source Type: clinical trials
A Study on BReast Cancer Patient Care Using chAtbot and Video Education for Radiation Therapy (BRAVE)
Conditions: Breast Neoplasms Interventions: Other: Video + Chatbot; Other: Video + Paper; Other: Paper + Chatbot; Other: Paper + Paper Sponsors: Yonsei University Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 17, 2024 Category: Research Source Type: clinical trials
SBRT Versus Hypofractionated Radiotherapy for Biochemically Recurrent or Oligometastatic Prostate Adenocarcinoma
Conditions: Biochemically Recurrent Prostate Carcinoma; Oligometastatic Prostate Carcinoma; Recurrent Prostate Adenocarcinoma; Stage IIB Prostate Cancer AJCC v8; Stage IIC Prostate Cancer AJCC v8; Stage III Prostate Cancer AJCC v8; Stage IV Prostate Cancer AJCC v8 Interventions: Drug: Antiandrogen Therapy; Procedure: Biospecimen Collection; Procedure: Bone Scan; Radiation: Hypofractionated Radiation Therapy; Procedure: Magnetic Resonance Imaging; Procedure: Positron Emission Tomography; Radiation: Stereotactic Body Radiation Therapy; Other: Survey Administration Sponsors: Mayo Clinic Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 15, 2024 Category: Research Source Type: clinical trials
RCT on Intralesional Rituximab Injection Versus ISRT in Ocular Adnexal MALT Lymphoma
Conditions: Primary Ocular Adnexal MALT Lymphoma Interventions: Drug: Rituximab; Radiation: Involved Site Radiation Therapy Sponsors: Zhongshan Ophthalmic Center, Sun Yat-sen University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 4, 2024 Category: Research Source Type: clinical trials
HYPofractionated Adjuvant RadioTherapy in 1 versus 2 weeks in high-risk patients with breast cancer (HYPART): a non-inferiority, open-label, phase III randomised trial
In this study, we will compare a 1-week schedule of hypofractionated adjuvant whole breast/chest wall and/or regional nodal radiotherapy against 2 weeks for locoregional disease control, toxicities, quality of life (QoL), survival and second cancers after primary surgery in patients with breas t cancer.MethodsEligible patients with breast cancer after mastectomy or breast conserving surgery (BCS) will be treated with a radiotherapy dose of 26 Gy in 5 fractions over 1 week in the study arm and 34 Gy in 10 fractions over 2 weeks in the control arm. The primary endpoint of this noninferiority study will be locoregional tumour...
Source: Trials - January 2, 2024 Category: Research Source Type: clinical trials
Effect of Bra Use During Radiotherapy for Breast Cancer Radiotherapy
Conditions: Breast Cancer; Radiation Therapy Interventions: Device: Group wearing a radiotherapy bra Sponsors: Yonsei University Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 21, 2023 Category: Research Source Type: clinical trials
A Phase Ⅱ Clinical Study of Adebrelimab Combined With Chemotherapy and Concurrent Radiotherapy for Extensive-Stage Oligometastatic SCLC
Conditions: Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases; Carcinoma, Bronchogenic; Bronchial Neoplasms; Lung Neoplasms; Small Cell Lung Carcinoma Interventions: Drug: Adebrelimab; Drug: Carboplatin/Cisplatin; Drug: Etoposide; Radiation: Radiation therapy Sponsors: Nanfang Hospital, Southern Medical University; Suzhou Suncadia Biopharmaceuticals Co., Ltd. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 20, 2023 Category: Research Source Type: clinical trials
Induction of double-strand breaks with the non-steroidal androgen receptor ligand flutamide in patients on androgen suppression: a study protocol for a randomized, double-blind prospective trial
This study will confirm in humans the pharmacodynamic effect of AR ligands to induce transient double-strand breaks when administered in the context of androgen deprivation as a novel therapy for prostate cancer. The findings of this study will permit the development of a larger trial evaluating flutamide pulsed-dose sequencing in association with fractionated external beam RT (+/ − brachytherapy). The study is ongoing, and preliminary data collection and recruitment are underway; analysis has yet to be performed.Trial registrationClinicalTrials.gov NCT03507608. Prospectively registered on 25 April 2018. (Source: Trials)
Source: Trials - December 16, 2023 Category: Research Source Type: clinical trials
Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma
Conditions: Ganglioneuroblastoma; Neuroblastoma Interventions: Procedure: Biospecimen Collection; Procedure: Bone Marrow Aspiration; Procedure: Bone Marrow Biopsy; Procedure: Bone Scan; Drug: Carboplatin; Drug: Cisplatin; Procedure: Computed Tomography; Drug: Cyclophosphamide; Drug: Dexrazoxane; Biological: Dinutuximab; Drug: Doxorubicin; Drug: Etoposide; Procedure: FDG-Positron Emission Tomography and Computed Tomography Scan; Procedure: Hematopoietic Cell Transplantation; Drug: Irinotecan; Drug: Isotretinoin; Procedure: Leukapheresis; Procedure: Magnetic Resonance Imaging; Drug: Melphalan; Radiation: Radiation Therapy; O...
Source: ClinicalTrials.gov - December 15, 2023 Category: Research Source Type: clinical trials
