Switching HIV+ Patients From Stribld to Genvoya Improved Proteinuria but Not eGFR
CROI 2016 Conference
Abstract Number:
795
Safety of Tenofovir Alafenamide in Renal Impairment
Author(s):
Anton Pozniak2, Jose R Arribas3, Samir K. Gupta4, Frank A. Post5, Anchalee Avihingsanon6, Gordon Crofoot7, Kenneth A. Lichtenstein8, Moti Ramgopal9, Ploenchan Chetchotisa kd10, Marshall W. Fordyce11 Clinical Research, Gilead Sciences Inc, Foster City, CA, United States. 2 (Source: Nelson Vergel's HIV Blog)
Source: Nelson Vergel's HIV Blog - April 8, 2016 Category: Infectious Diseases Authors: Anonymous Source Type: blogs
Switching HIV+ Patients From Stribld to Genvoya Improved Proteinuria but Not eGFR
CROI 2016 Conference
Abstract Number:
795
Safety of Tenofovir Alafenamide in Renal Impairment
Author(s):
Anton Pozniak2, Jose R Arribas3, Samir K. Gupta4, Frank A. Post5, Anchalee Avihingsanon6, Gordon Crofoot7, Kenneth A. Lichtenstein8, Moti Ramgopal9, Ploenchan Chetchotisakd10, Marshall W. Fordyce11 Clinical Research, Gilead Sciences Inc, Foster City, CA, United States. 2 (Source: Nelson Vergel's HIV Blog)
Source: Nelson Vergel's HIV Blog - April 7, 2016 Category: Infectious Diseases Authors: Nelson Vergel Source Type: blogs
A Woman with Proteinuria via Now@NEJM
Posted on infosnack. (Source: Kidney Notes)
Source: Kidney Notes - November 13, 2015 Category: Urology & Nephrology Authors: Joshua Schwimmer Source Type: blogs
Using EHR Data to Manage Hypertension More Aggressively
By JOSH GRAY
The NIH (National Institutes of Health) recently released initial results from its SPRINT (Systolic Blood Pressure Intervention Trial) study, suggesting more aggressive treatment for hypertension may reduce risk for cardiovascular events by 30 percent and the risk of death by 25 percent.
The SPRINT group recruited over 9,000 non-diabetic subjects aged 50 or older with systolic blood pressure (SBP) over 130. Individuals were then randomly assigned to either a standard treatment goal of lowering SBP below 140 or a more intensive treatment goal of lowering SBP below 120. The findings were sufficiently compellin...
Source: The Health Care Blog - October 6, 2015 Category: Consumer Health News Authors: Simon Nath Tags: Uncategorized Source Type: blogs
New Treatments For FSGS -ASN Conference
Idiopathic focal and segmental glomerular sclerosis or FSGS is one of the most common causes of non diabetic kidney disease in the world and also one of the least satisfying to treat due to the difficulty with initiating and maintaining a durable remission. For decades the standard of treatment has been steroid therapy in high doses given either daily or every other day. This results in significant toxicity which includes the development of diabetes mellitus, osteoporosis, personality changes, weight gain, easy bruising etc. Yet these negative effects of steroid therapy are outweighed significantly by the result of not tre...
Source: All Kidney News - September 29, 2015 Category: Urology & Nephrology Authors: jadhavbca Tags: Kidney News FSGS TNF Source Type: blogs
New Treatments For FSGS -ASN Conference
Idiopathic focal and segmental glomerular sclerosis or FSGS is one of the most common causes of non diabetic kidney disease in the world and also one of the least satisfying to treat due to the difficulty with initiating and maintaining a durable remission. For decades the standard of treatment has been steroid therapy in high doses given either daily or every other day. This results in significant toxicity which includes the development of diabetes mellitus, osteoporosis, personality changes, weight gain, easy bruising etc. Yet these negative effects of steroid therapy are outweighed significantly by the result of not tre...
Source: All Kidney News - September 29, 2015 Category: Urology & Nephrology Authors: jadhavbca Tags: Kidney News FSGS TNF Source Type: blogs
A new marker and prognosticator for uremic LV dysfunction
Heart and kidney work in tandem and share a close functional relationship during health and disease.Progressive cardiac failure causes kidney function to deteriorate,what we call it as cardio -renal syndrome.Similarly, progressive renal disease inflicts either a reversible /irreversible LV dysfunction .The mechanism of LV dysfunction has not been fully decoded. It is primarily biochemical mediated but at later stages it can be irreversible and structural damage can occur.
We believe uremic micro molecules leaking from plasma into cardiac Interstitium (Myocardial proteinuria ?) are somehow responsible for the pr...
Source: Dr.S.Venkatesan MD - May 30, 2015 Category: Cardiology Authors: dr s venkatesan Tags: Cardio Nephrology biochemistry of cardiac failure c-alb c-albumin carbamylated albumin dialysable lv dysfunction mechansim of lv dysfucntion in ckd uremic cardiomyopathy uremic lv dysfunction Source Type: blogs
Guidelines have consequences – intended and unintended
This article spurred my anger – Hypertension Guidelines: Clear as Mud
I left this comment on the Medscape site:
The problem is really more complex than presented. The problem resides in the belief that we should always have a guideline. Some medical issues deserve guidelines, e.g., ACE or ARB (if tolerated) for CKD with proteinuria, statin therapy for secondary prevention in CAD, but many other questions are much more complex and trying to force a guideline for those issues has been and will continue to be a mistake.
We must stop insisting on calling expert opinions guidelines. We should only call something a g...
Source: DB's Medical Rants - February 12, 2014 Category: Health Medicine and Bioethics Commentators Authors: rcentor Tags: Medical Rants Source Type: blogs
One More Reason to Rethink Your Soda Habit
We've heard a lot about the various evils of drinking too much soda, and a new study from Japan adds a new health concern regarding the beverage: Drinking too many soft drinks may cause kidney problems.
Researchers at Osaka University found that study subjects who drank two or more non-diet sodas per day were more likely to show signs of proteinuria, an elevated amount of protein in the urine, which can be a sign of kidney dysfunction. (Source: The ND Blog: Notes from the Nutritionista by Monica Reinagel, L.D.N., C.N.S.)
Source: The ND Blog: Notes from the Nutritionista by Monica Reinagel, L.D.N., C.N.S. - November 13, 2013 Category: Nutritionists and Food Scientists Tags: Health diet health news kidneys soda study Source Type: blogs
Why Do I Need to Do This Stuff, Anyway?
By Jan Chait
It was the day I fired my primary-care physician (PCP). He was going over my vital signs with me and noted my blood pressure as being 140/90 (or something like that). "That's good," he said.
"No," I responded — I never could keep my mouth shut — "that's too high for somebody who has diabetes."
And that's when the tirade began, beginning with my audacity in talking back to him and then going into I needed to fire my endocrinologist, who never should have let me have an insulin pump, they're dangerous, yada, yada, yada.
That was 13 or so years and 4 pumps ago. I still have the endocrinologist.
Becau...
Source: Diabetes Self-Management - September 4, 2013 Category: Diabetes Authors: Jan Chait Source Type: blogs
Being Kind to Your Kidneys: Kidney Function Tests
By Amy Campbell
A big part of "being kind" to your kidneys is taking charge early on. In discussing diabetes, we often talk about "knowing your numbers," such as your A1C and blood pressure. These are important numbers, of course, but what's often overlooked is your kidney numbers. These numbers may or may not be something that your doctor talks to you about — if you don't know about your kidney test results, ask! In the meantime, here's a rundown of some common tests, often called kidney function tests, that you should be familiar with.
Microalbumin test
The microalbumin test is a urine test that checks for very sma...
Source: Diabetes Self-Management - June 10, 2013 Category: Diabetes Authors: Amy Campbell Source Type: blogs
Goodbye, nephrotic syndrome!
Joanna posted this intriguing and wonderful tale of nephrotic syndrome reversed with wheat elimination:
No more nephrotic syndrome since starting
Wheat Belly–this is MASSIVE. I need to share my story Dr Davis.
I’m 30, I had heavy proteinuria [protein loss in the urine] for years. I went strictly wheat-free in July, 2012, and today I discovered its down to 0.5 g [per day]. No meds, just my interest in nutrition, in particular my 10 months on Wheat Belly. I’ve lost 20 kg [44 pounds], I weigh 54 kg [118.8 pounds] now, zero fluid retention, and the receptionist at the doctor’s office didn’t recogn...
Source: Wheat Belly Blog - May 16, 2013 Category: Cardiology Authors: Dr. Davis Tags: Wheat-elimination success stories Source Type: blogs
New definitions for CKD! Medrants version 1.0
This represents my first attempt at explaining the new CKD definitions. I invite my readers, especially my loyal renal readers, to suggest modifications. This rant will become the basis for a regular talk, and I want to get it right. Thanks in advance for your suggestions.
Ten years after we have new definitions for CKD. Soon after they established the initial stages, authors began to argue that we should divide stage 3 into 3a and 3b. Now they have.
For those who want to read all the details - KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidn...
Source: DB's Medical Rants - January 18, 2013 Category: Health Medicine and Bioethics Commentators Authors: rcentor Tags: Attending Rounds Medical Rants Source Type: blogs
Test results – the complete history
I finally had the brainwave of putting all my test results into a spreadsheet to make it easier to view changes over time.
You can view them here if you so desire:
https://docs.google.com/spreadsheet/pub?hl=en_US&hl=en_US&key=0AhX6YZKS2qpCdFpObVlQQXNmMjBfT19kUUdxUHAxaEE&output=html
The progress points are:
Serum Creatinine back to same level of 18 months ago.
Proteinuria (protein in urine) way down.
Increased Serum Hemoglobin (reduction of anemia)
Blood pressure reduced.
The “lack of progress” points are:
Serum Creatinine and Creatinine Clearance unchanged (i.e. no improvement in kidney function)...
Source: All Kidney News - October 25, 2010 Category: Urology & Nephrology Authors: admin Tags: Uncategorized Source Type: blogs
