Zafgen shelves another drug; chief medical officer exits
The bad news keeps coming for Boston biotech Zafgen Inc., which revealed Monday that it is shelving another drug due to safety concerns.
Zafgen (Nasdaq: ZFGN) has hit multiple dead ends while attempting to treat metabolic diseases such as Type 2 diabetes and Prader-Willi Syndrome by inhibiting an enzyme known as MetAP2.
Testing on the company's lead drug for Type 2 diabetes, ZGN-1061, remains on a clinical hold in the U.S. nearly six months after the FDA voiced concerns about a potential cardiovascular… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - March 12, 2019 Category: Biotechnology Authors: Allison DeAngelis Source Type: news
Zafgen shelves another drug; chief medical officer exits
The bad news keeps coming for Boston biotech Zafgen Inc., which revealed Monday that it is shelving another drug due to safety concerns.
Zafgen (Nasdaq: ZFGN) has hit multiple dead ends while attempting to treat metabolic diseases such as Type 2 diabetes and Prader-Willi Syndrome by inhibiting an enzyme known as MetAP2.
Testing on the company's lead drug for Type 2 diabetes, ZGN-1061, remains on a clinical hold in the U.S. nearly six months after the FDA voiced concerns about a potential cardiovascular… (Source: bizjournals.com Health Care News Headlines)
Source: bizjournals.com Health Care News Headlines - March 12, 2019 Category: Health Management Authors: Allison DeAngelis Source Type: news
Guanfacine extended release for the reduction of aggression, attention-deficit/hyperactivity disorder symptoms, and self-injurious behavior in Prader-Willi syndrome-a retrospective cohort study - Singh D, Wakimoto Y, Filangieri C, Pinkhasov A, Angulo M.
OBJECTIVE: To examine the role of Guanfacine Extended Release (GXR) in the management of behavioral disturbances in patients with Prader-Willi Syndrome (PWS). METHODS: Twenty from a total of 27 individuals with genetically confirmed PWS, 6-26 years... (Source: SafetyLit)
Source: SafetyLit - February 11, 2019 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
What is Genomic Imprinting?
Discussion
Silver-Russell syndrome (SRS) is a rare genetic syndrome first characterized by Silver in 1953 and Russell in 1954. Patients with SRS have characteristic growth patterns and clinical findings, although within an individual patient there are phenotypical differences. Patients are born small-for-gestational age (SGA) but have a relative macrocephaly. There is postnatal growth failure and difficulty feeding, with a very low body mass index. Body asymmetry (e.g. hemihypertrophy) and facial features (i.e. protruding forehead, triangular facies, micrognathia, dental anomalies, downturned mouth corners, and ear anomali...
Source: PediatricEducation.org - November 26, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Mother, 36, ignores her daughter ’s screams for food as rare condition leaves her constantly hungry
Megan Fitzgerald, seven, from Hull, has Prader-Willi Syndrome. Her mother, Tracy Fitzgerald, 36, says she looks like a 'horrible mother' in public, and can't even speak about food in front of her child. (Source: the Mail online | Health)
Source: the Mail online | Health - November 22, 2018 Category: Consumer Health News Source Type: news
Mother, 36, ignores her daughter’s screams for food as rare condition leaves her constantly hungry
Megan Fitzgerald, seven, from Hull, has Prader-Willi Syndrome. Her mother, Tracy Fitzgerald, 36, says she looks like a 'horrible mother' in public, and can't even speak about food in front of her child. (Source: the Mail online | Health)
Source: the Mail online | Health - November 22, 2018 Category: Consumer Health News Source Type: news
Anna Hankins who suffers from Prader-Willi Syndrome wins beauty pageant
Anna Hankins, from Louisville, Mississippi, who was diagnosed with Prader-Willi Syndrome at two years old, developed an insatiable appetite as a toddler, which caused her to steal food off plates. (Source: the Mail online | Health)
Source: the Mail online | Health - March 26, 2018 Category: Consumer Health News Source Type: news
Teenage girl, 15, suffers from a rare condition that makes her so hungry she rifles through bins
Anna Hankins, from Louisville, Mississippi, who was diagnosed with Prader-Willi Syndrome at two years old, developed an insatiable appetite as a toddler, which caused her to steal food off plates. (Source: the Mail online | Health)
Source: the Mail online | Health - March 26, 2018 Category: Consumer Health News Source Type: news
An enzyme deficiency contributes to disease symptoms in Prader-Willi syndrome
Researchers discovered that a deficiency of the enzyme prohormone convertase 1, contributes to disease symptoms in Prader-Willi Syndrome, a genetic disorder. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news
Letting silenced genes speak
(University of Connecticut) Stem cell researchers at UConn Health have reversed Prader-Willi syndrome in brain cells growing in the lab. The discovery provides clues that could lead to a treatment for Prader-Willi, a genetic disorder that silences genes necessary for normal brain function. Prader-Willi occurs in about one out of every 15,000 births, and is the most common genetic cause of life-threatening childhood obesity. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 25, 2018 Category: International Medicine & Public Health Source Type: news
FDA Grants INSYS Therapeutics Fast Track Designation for Cannabidiol (CBD) Oral Solution as Investigational Treatment for Prader-Willi Syndrome
PHOENIX, Dec. 26, 2017 -- (Healthcare Sales & Marketing Network) -- INSYS Therapeutics, Inc. (NASDAQ:INSY), announced today that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation to the companys cannabidiol (CBD) oral solution... Biopharmaceuticals, FDA INSYS Therapeutics, cannabidiol, Prader-Willi Syndrome (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - December 26, 2017 Category: Pharmaceuticals Source Type: news
Pakistani boy who weighs 19 stone has weight-loss surgery
Muhammad Yousuf, seven, from Kasur in Pakistan, weighs four times more than an average child of his age. He is thought to suffer from Prader-Willi syndrome, which causes an insatiable appetite. (Source: the Mail online | Health)
Source: the Mail online | Health - December 6, 2017 Category: Consumer Health News Source Type: news
Seven-year-old who weighs 19 stone has weight-loss surgery
Muhammad Yousuf from Kasur in Punjab, Pakistan, weighs four times more than an average child of his age. He is thought to suffer from Prader-Willi syndrome, which causes an insatiable appetite. (Source: the Mail online | Health)
Source: the Mail online | Health - December 6, 2017 Category: Consumer Health News Source Type: news
Boy with Prader-Willi syndrome means never feels full
Frankie Udall, from Billericay, Essex, suffers from Prader-Willi syndrome, an incurable disease that can make him scream and lash out due to his hunger. (Source: the Mail online | Health)
Source: the Mail online | Health - November 13, 2017 Category: Consumer Health News Source Type: news
Is THIS Mexican boy the world's fattest baby?
Luis Manuel, 10 months, from Tecoman in the western Mexican state of Colima, tips the scales at a mammoth 4st 10lbs (30kg). Doctors fear he has the incurable Prader-Willi syndrome. (Source: the Mail online | Health)
Source: the Mail online | Health - October 20, 2017 Category: Consumer Health News Source Type: news
