Medicare finalizes substantial improvements that focus on primary care, mental health, and diabetes prevention
Today, the Centers for Medicare& Medicaid Services (CMS) finalized the 2017 Physician Fee Schedule final rule that recognizes the importance of primary care by improving payment for chronic care management and behavioral health. The rule also finalizes many of the policies to expand the Diabetes Prevention Program model test to eligible Medicare beneficiaries, the Medicare Diabetes Prevention Program (MDPP) expanded model, starting January 1, 2018. (Source: NIDDK News)
Source: NIDDK News - April 4, 2019 Category: Endocrinology Source Type: news

New tool reveals insights into maturation of red blood cells
Using detailed genetic data along with a recently developed analytical tool called “population balance analysis” (PBA), investigators have developed models capable of predicting the mature blood cell type of early stage (progenitor) blood cells.  (Source: NIDDK News)
Source: NIDDK News - March 22, 2019 Category: Endocrinology Source Type: news

From body to brain and back again —how the hormone leptin utilizes brain cell circuits to regulate appetite, calorie burning, and glucose levels
Scientists have used a new genetic tool in mice to map out the cellular brain circuits used by the hormone leptin to control energy balance (calories consumed versus calories burned) and blood glucose (sugar) levels.  (Source: NIDDK News)
Source: NIDDK News - March 22, 2019 Category: Endocrinology Source Type: news

Diabetes drug alters vitamin D levels, possibly explaining increased bone fracture risk
Scientists found that the diabetes drug canagliflozin reduces vitamin D levels and calcium uptake, which may explain why this drug can increase the risk of bone fractures.  (Source: NIDDK News)
Source: NIDDK News - March 22, 2019 Category: Endocrinology Source Type: news

Primarily home-based cognitive behavior therapy as effective as standard therapy for treatment of irritable bowel syndrome
New research has shown that a mainly home-based behavior therapy regimen to treat irritable bowel syndrome (IBS) is just as effective as a similar, more expensive, strictly clinic-based therapy, and is more effective than an education-only approach.  (Source: NIDDK News)
Source: NIDDK News - March 22, 2019 Category: Endocrinology Source Type: news

Finding a new home —how good (and bad) bacteria colonize the gut
Three studies have revealed details of what happens when a community of bacteria inhabiting the gut is disrupted and then rebuilt by a change in diet or by adding bacteria from a healthy donor, providing valuable insights that could help with the design of microbe-based therapies for the treatment of gastrointestinal infections and other digestive diseases. (Source: NIDDK News)
Source: NIDDK News - March 22, 2019 Category: Endocrinology Source Type: news

Kidney protein could expand the window for developmental nephron production
A study in mice showed that a partial reduction of the protein hamartin in the developing kidney leads to larger numbers of nephrons —the basic functional unit of the kidney.  (Source: NIDDK News)
Source: NIDDK News - March 22, 2019 Category: Endocrinology Source Type: news

Understanding calorie burning in early pregnancy —moving toward improving health for mothers and children
New research is shedding light on calorie consumption and calorie burning in early pregnancy in women with obesity, which could inform strategies to promote healthy gestational weight gain and reduce racial disparities in pregnancy outcomes.  (Source: NIDDK News)
Source: NIDDK News - March 22, 2019 Category: Endocrinology Source Type: news

Zebrafish employ cellular shield to protect blood stem cells from damaging ultraviolet light
While studying the blood stem cells that reside in the kidney of the zebrafish embryo, researchers observed that cells called melanocytes were positioned above the stem cells in an umbrella pattern, and subsequently showed this umbrella served as a shield protecting stem cells from damaging ultraviolet (UV) light.  (Source: NIDDK News)
Source: NIDDK News - March 22, 2019 Category: Endocrinology Source Type: news

Studies show difficulty in treating type 2 diabetes in youth and highlight unique aspects of the disease in young people
New research reveals that the only two medications approved for pediatric type 2 diabetes do not prevent rapid progression of prediabetes or recent onset type 2 diabetes in young people with the disease; however, analyses comparing metabolic tests of adults in a companion study and the youth study participants are helping scientists understand how the disease differs with age, which may one day lead to better treatment approaches. (Source: NIDDK News)
Source: NIDDK News - March 22, 2019 Category: Endocrinology Source Type: news

Preserving insulin production in people with newly diagnosed type 1 diabetes
Researchers have discovered that treatment with a medicine that suppresses the immune system, called anti-thymocyte globulin (ATG), preserved insulin production and improved blood glucose (sugar) control for at least a year in people with newly diagnosed type 1 diabetes, as compared to placebo (no medicine).  (Source: NIDDK News)
Source: NIDDK News - March 22, 2019 Category: Endocrinology Source Type: news

Treatment for common urinary ailment no longer carved in stone
Newly published results from a large clinical trial indicate that a drug frequently used in the emergency room to treat people with urinary stone disease has no benefit if the stones are below a certain size.  (Source: NIDDK News)
Source: NIDDK News - March 22, 2019 Category: Endocrinology Source Type: news

Story of discovery: newborn screening for lysosomal storage diseases
Newborn screening for lysosomal storage diseases (Source: NIDDK News)
Source: NIDDK News - March 22, 2019 Category: Endocrinology Source Type: news

From body to brain and back again —how the hormone leptin utilizes brain cell circuits to regulate appetite, calorie burning, and glucose levels
Scientists have used a new genetic tool in mice to map out the cellular brain circuits used by the hormone leptin to control energy balance (calories consumed versus calories burned) and blood glucose (sugar) levels.  (Source: NIDDK News)
Source: NIDDK News - March 19, 2019 Category: Endocrinology Source Type: news

Diabetes drug alters vitamin D levels, possibly explaining increased bone fracture risk
Scientists found that the diabetes drug canagliflozin reduces vitamin D levels and calcium uptake, which may explain why this drug can increase the risk of bone fractures.  (Source: NIDDK News)
Source: NIDDK News - March 19, 2019 Category: Endocrinology Source Type: news

Primarily home-based cognitive behavior therapy as effective as standard therapy for treatment of irritable bowel syndrome
New research has shown that a mainly home-based behavior therapy regimen to treat irritable bowel syndrome (IBS) is just as effective as a similar, more expensive, strictly clinic-based therapy, and is more effective than an education-only approach.  (Source: NIDDK News)
Source: NIDDK News - March 19, 2019 Category: Endocrinology Source Type: news

Finding a new home —how good (and bad) bacteria colonize the gut
Three studies have revealed details of what happens when a community of bacteria inhabiting the gut is disrupted and then rebuilt by a change in diet or by adding bacteria from a healthy donor, providing valuable insights that could help with the design of microbe-based therapies for the treatment of gastrointestinal infections and other digestive diseases. (Source: NIDDK News)
Source: NIDDK News - March 19, 2019 Category: Endocrinology Source Type: news

Kidney protein could expand the window for developmental nephron production
A study in mice showed that a partial reduction of the protein hamartin in the developing kidney leads to larger numbers of nephrons —the basic functional unit of the kidney.  (Source: NIDDK News)
Source: NIDDK News - March 19, 2019 Category: Endocrinology Source Type: news

Understanding calorie burning in early pregnancy —moving toward improving health for mothers and children
New research is shedding light on calorie consumption and calorie burning in early pregnancy in women with obesity, which could inform strategies to promote healthy gestational weight gain and reduce racial disparities in pregnancy outcomes.  (Source: NIDDK News)
Source: NIDDK News - March 19, 2019 Category: Endocrinology Source Type: news

Zebrafish employ cellular shield to protect blood stem cells from damaging ultraviolet light
While studying the blood stem cells that reside in the kidney of the zebrafish embryo, researchers observed that cells called melanocytes were positioned above the stem cells in an umbrella pattern, and subsequently showed this umbrella served as a shield protecting stem cells from damaging ultraviolet (UV) light.  (Source: NIDDK News)
Source: NIDDK News - March 19, 2019 Category: Endocrinology Source Type: news

Studies show difficulty in treating type 2 diabetes in youth and highlight unique aspects of the disease in young people
New research reveals that the only two medications approved for pediatric type 2 diabetes do not prevent rapid progression of prediabetes or recent onset type 2 diabetes in young people with the disease; however, analyses comparing metabolic tests of adults in a companion study and the youth study participants are helping scientists understand how the disease differs with age, which may one day lead to better treatment approaches. (Source: NIDDK News)
Source: NIDDK News - March 19, 2019 Category: Endocrinology Source Type: news

Preserving insulin production in people with newly diagnosed type 1 diabetes
Researchers have discovered that treatment with a medicine that suppresses the immune system, called anti-thymocyte globulin (ATG), preserved insulin production and improved blood glucose (sugar) control for at least a year in people with newly diagnosed type 1 diabetes, as compared to placebo (no medicine).  (Source: NIDDK News)
Source: NIDDK News - March 19, 2019 Category: Endocrinology Source Type: news

Treatment for common urinary ailment no longer carved in stone
Newly published results from a large clinical trial indicate that a drug frequently used in the emergency room to treat people with urinary stone disease has no benefit if the stones are below a certain size.  (Source: NIDDK News)
Source: NIDDK News - March 19, 2019 Category: Endocrinology Source Type: news

Story of discovery: newborn screening for lysosomal storage diseases
Newborn screening for lysosomal storage diseases (Source: NIDDK News)
Source: NIDDK News - March 19, 2019 Category: Endocrinology Source Type: news

Story of discovery: getting a Notch up on cord blood cell transplantation
Researchers supported by NIDDK have discovered key factors that promote blood stem cell growth and maturation, and, with these insights, have developed ways to expand the numbers of cells from cord blood for use in transplants. (Source: NIDDK News)
Source: NIDDK News - March 19, 2019 Category: Endocrinology Source Type: news

Story of discovery: discoveries moving towards understanding and personalized treatment of inflammatory bowel disease
Researchers have discovered ways in which the bacteria and other microbes that reside in the gut —the gut microbial community or microbiome—can affect risk of IBD, and efforts such as NIDDK’s IBD Genetics Consortium are shedding new light on the genetic foundations of the disease. (Source: NIDDK News)
Source: NIDDK News - March 19, 2019 Category: Endocrinology Source Type: news

Healthy Infants Harbor Intestinal Bacteria That Protect Against Food Allergy
New research suggests that the gut microbiome may help prevent the development of cow ’s milk allergy. (Source: NIDDK News)
Source: NIDDK News - January 15, 2019 Category: Endocrinology Source Type: news

Better mouse model built to enable precision-medicine research for Alzheimer's
Incorporating genetic diversity into a mouse model of Alzheimer ’s disease resulted in greater overlap with the genetic, molecular and clinical features of this pervasive human disease, according to a study funded by the National Institute on Aging (NIA), part of the National Institutes of Health. The study also suggests that adding genetic diversity may be ke y to improving the predictive power of studies using mouse models and increasing their usability for precision medicine research for Alzheimer’s. (Source: NIDDK News)
Source: NIDDK News - December 28, 2018 Category: Endocrinology Source Type: news

Vitamin E helps diminish a type of fatty liver disease in children
A specific form of vitamin E improved the most severe form of fatty liver disease in some children, according to a study funded by the NIH. Results appear in the April 27 issue of theJournal of the American Medical Association. A previous study found vitamin E effective in some adults with the disease. (Source: NIDDK News)
Source: NIDDK News - September 10, 2018 Category: Endocrinology Source Type: news

New tool reveals insights into maturation of red blood cells
Using detailed genetic data along with a recently developed analytical tool called “population balance analysis” (PBA), investigators have developed models capable of predicting the mature blood cell type of early stage (progenitor) blood cells.  (Source: NIDDK News)
Source: NIDDK News - June 27, 2018 Category: Endocrinology Source Type: news

Gut microbe helps program immune cells via dietary metabolites
Scientists have identified an important role for a gut bacterial species and its metabolites in the maturation of a key immune cell.  (Source: NIDDK News)
Source: NIDDK News - June 27, 2018 Category: Endocrinology Source Type: news

Health benefits of intensive blood pressure control outweigh a slight risk of developing kidney disease
A new study found that in people who do not have chronic kidney disease (CKD), an intensive blood pressure control regimen increases risk of declining kidney function; this risk is generally outweighed by a reduced risk for cardiovascular events and death. (Source: NIDDK News)
Source: NIDDK News - June 27, 2018 Category: Endocrinology Source Type: news

New insights on risk factors for severe hypoglycemia in people with type 2 diabetes
Results of NIDDK-supported research have improved understanding of factors that can help predict vulnerability to severe hypoglycemia in African American and white individuals with type 2 diabetes. (Source: NIDDK News)
Source: NIDDK News - June 27, 2018 Category: Endocrinology Source Type: news

Understanding how cells in the pancreas change with age
Researchers have used sophisticated technologies to examine individual cells from healthy human pancreata to understand how the cells change with age. (Source: NIDDK News)
Source: NIDDK News - June 27, 2018 Category: Endocrinology Source Type: news

A tale of two sugars —fructose and glucose cause differing metabolic effects
Researchers have found that the sugars fructose and glucose cause different metabolic effects and health outcomes in mice, but only in animals eating a high-fat diet.  (Source: NIDDK News)
Source: NIDDK News - June 27, 2018 Category: Endocrinology Source Type: news

Restricted feeding leads to metabolic benefits in mice
Scientists found that feeding mice twice a day, with complete food restriction in between, improved metabolism and prevented age- and obesity-associated metabolic defects compared to allowing them 24-hour access to food.  (Source: NIDDK News)
Source: NIDDK News - June 27, 2018 Category: Endocrinology Source Type: news

Bacterial enzyme implicated in inflammatory bowel disease
Using human samples and animal models, researchers have found that an enzyme produced by certain bacteria could disrupt the gut microbiome, potentially playing a significant role in the development of inflammatory bowel disease. (Source: NIDDK News)
Source: NIDDK News - June 27, 2018 Category: Endocrinology Source Type: news

Turning pancreatic alpha cells into insulin-producing beta-like cells via gene therapy
Scientists have developed a new way to replace lost beta cells in mouse models of type 1 diabetes.  (Source: NIDDK News)
Source: NIDDK News - June 27, 2018 Category: Endocrinology Source Type: news

Microbial “irony”—bacteria provide keys to battling urinary tract infections
Researchers have identified two different molecules that can limit growth of microbes that cause urinary tract infections (UTIs), adding to approaches being pursued to develop new strategies for clinical treatment of UTIs.  (Source: NIDDK News)
Source: NIDDK News - June 27, 2018 Category: Endocrinology Source Type: news

Genes newly associated with body weight
Scientists ’ recent analysis of hundreds of thousands of human genomes has identified new links between certain gene sequence variations and body mass index (BMI), a measure of weight relative to height. (Source: NIDDK News)
Source: NIDDK News - June 27, 2018 Category: Endocrinology Source Type: news

“Sensing” a genetic predisposition to obesity
New research suggests a mechanism by which antenna-like sensory projections, called primary cilia, located on brain cells play a role in the genetic predisposition to and development of obesity. (Source: NIDDK News)
Source: NIDDK News - June 27, 2018 Category: Endocrinology Source Type: news

Becoming unglued: how a genetic variant may affect the gut barrier and contribute to inflammatory bowel disease
Researchers have found that a genetic variant may impart risk for inflammatory bowel disease (IBD) by disrupting the cellular “glue” that keeps the gut’s lining intact.  (Source: NIDDK News)
Source: NIDDK News - June 27, 2018 Category: Endocrinology Source Type: news

Shedding Light on the Functional Genetic Architecture of Inflammatory Bowel Disease
Recent findings have uncovered two genetic variants that increase the risk for inflammatory bowel disease and also provided clues to their function. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Finding the Genetic Cause of a Form of Hyperparathyroidism
Researchers have identified genetic differences that can cause familial isolated hyperparathyroidism. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

The Sweet Smell of Success —A Protein in the Kidney Helps the Body Retain Sugar
Scientists identified a protein in the mouse kidney that helps prevent the body from excreting glucose. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Dynamic Bladder and Bacterial Changes Hold Clues to Therapies
In two recent studies, researchers delved into changes that occur in the bladder and invading bacteria that affect both acute and recurrent infection. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Large-scale Human Genetics Study of Fat Depots Identifies Gene Regions Associated with Depot- and Gender-specific Fat Cell Development
The largest-scale human genetics study of its kind has identified seven new gene regions associated with individual variability in body fat. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Donor Outcomes in the Years After Living Donor Liver Transplantation
Studies provide a more complete picture of how living donor liver transplantation affects donors in a myriad of ways. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Identification of Signaling Pathway Involved in Diabetic Nerve Damage Leads to Discovery of Promising New Therapy
Blocking a signaling pathway involved in diabetic nerve damage could prevent or reverse that damage in mice. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Elucidating Complex Interactions Between Human Gut Microbes, Diet, and Response
Research is illuminating the multiple levels of complex interactions that contribute to how human gut microbes affect health. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news