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Number of Americans with diabetes rises to nearly 26 million
(Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

NIH urges — Be kind to your kidneys!
(Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

NIH grantees win 2011 Nobel Prize in physiology or medicine
(Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

NIH study to test treatment for fatty liver disease in children
(Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

NIH partners with industry to create new Living Lab for research into molecular structures that can affect disease
(Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

New NIH fact sheet explains test for diabetes, pre-diabetes
(Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

New website: NIH Clinical Research Trials and You
(Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

"Biggest Loser" study finds modest diet and exercise can sustain weight loss
(Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Researchers discover 71 new human genes associated with bowel diseases
(Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Let ’s Not Sugar Coat It: Evidence Is Emerging that Fructose and Glucose Elicit Different Brain Responses
Findings from a small study indicated that glucose, but not fructose, may promote satiety in humans, partly due to glucose effects on specific brain regions. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

New Mechanism Proposed for Glucose-lowering Effect of Metformin, a Drug for Type 2 Diabetes
Evidence that metformin tampers with glucagon-induced glucose output by disrupting glucagon signaling in liver cells may lead to new type 2 diabetes treatments. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Fending Off Infection in the Urinary Tract
Investigators have begun to characterize the potent, broad-spectrum antimicrobial activity of RNase 7 in the urinary tract during infection. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Treatment To Prevent Hepatitis C Recurrence After Liver Transplantation
In a clinical trial, researchers found that antiviral therapy prior to a liver transplant can prevent hepatitis C recurrence in some patients. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Biliary Atresia Susceptibility Gene Identified in Patients
Researchers identified the GPC1 gene as being potentially lacking in biliary atresia patients. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Gene Mutations Linked to Hypertension
KLHL3 and CUL3 gene mutations in pseudohypoaldosteronism type II suggest further study of the role of these genes in blood pressure/fluid and salt regulation. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Gut Microbes Contribute to Severe Malnutrition in Young Malawian Twins
Finding that dietary deficiency and a certain gut microbial profile caused severe malnutrition may aid in developing interventions for childhood malnutrition. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Working Out the Health Benefits of Autophagy
Autophagy, known to help protect against cancer/other diseases, may help counteract dangerous metabolic consequences of obesity, including type 2 diabetes risk. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Understanding the Genetic Risk for Type 2 Diabetes
Increased understanding of genetic factors that influence type 2 diabetes development may lead to tailored prevention/treatment strategies and new therapies. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Uncovering Genetics Contributing to Diabetes Health Disparities
Studies identify 11 genomic regions that may influence elevated risk of type 2 diabetes in African Americans and South Asians. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Transparent Fish Illuminates Formation of Ductal Network
Zebrafish were used to study development of the liver and of ducts connecting liver, pancreas, intestine; and the role of proteins and genes in these processes. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

The Quest To Make Visceral Fat Burn Itself
Studies of brown fat progenitor cells/brown fat development regulation may lead to obesity therapies that cause white fat tissue to behave more like brown fat. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

The Double-edged Sword of Hepcidin
Smaller forms of hepcidin lowered serum iron levels in iron overload, and other small compounds reduced hepcidin levels in anemia of chronic inflammation. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Small Molecules Hold Promise to Prevent Type 1 Diabetes
Small molecules show potential in treating autoimmune disease and type 1 diabetes. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Small Molecule Stabilizers as a Potential Treatment for Transthyretin Familial Amyloid Polyneuropathy
Diflunisal and tafamidis identified as small molecule stabilizers with potential to treat transthyretin familial amyloid polyneuropathy (TTR FAP). (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Signaling Pathway Found to Regulate Regeneration of Insulin producing β Cells
The adenosine signaling pathway may be important regulator of ? cell regeneration. Promoting ? cell proliferation selectively has potential to treat diabetes. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Research Identifies Key Hurdle in Quest for Cystic Fibrosis Treatment
Research offers important insight for new drug therapy to restore proper CFTR folding/function in most with cystic fibrosis, those with the ?F508 mutation. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Reducing Sugary Drinks Could Reduce Obesity
Studies support a link between consumption of sugar-sweetened beverages and excess weight gain and suggest potential target behavior for obesity prevention. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Long-range Regulation of How Genes are Turned “Off” and “On”
Two studies increased understanding of transcriptional regulation of some red blood cell genes and how they turn on/off; may help in treating blood diseases. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

LiverTox: A New Online Resource for Information on Drug-induced Liver Injury
LiverTox is a web-based resource for information on drug-induced liver injury from prescription and OTC drugs, and complementary and alternative medicines. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Kidney Damage: New Insights into Initiation, New Targets for Therapy
Five studies of the complex system of regulation in kidney fibrosis following injury identified potential targets to prevent or reverse kidney fibrosis. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Gut Microbes Transmit Susceptibility to Nonalcoholic Fatty Liver Disease Progression
Studies have expanded understanding of the role of gut microbes in nonalcoholic fatty liver disease (NAFLD) progression to nonalcoholic steatohepatitis (NASH). (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Genetic Variants Linked to Earlier Kidney Failure in African Americans
African Americans with APOL1 gene experience faster rate of decline in kidney function and begin hemodialysis at a younger age versus those without the gene. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Dr. Peter P. Reese and Dr. Georgios Skiniotis: NIDDK-Supported Scientists Receive Presidential Award
Drs. Peter Reese and Georgios Skiniotis received the 2011 PECASE for their work in organ transplant research and signaling surface receptors, respectively. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Alpha-1 Antitrypsin Deficiency —From Genes to Therapies
NIH funded research has identified genetic factors and clinical manifestations of alpha-1 antitrypsin deficiency which may lead to future treatments. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

A Time to Sleep and a Time to Metabolize
Studying the role of factors such as Rev-erbs and HDAC3 in circadian control of metabolism may lead to behavioral strategies to prevent metabolic disease. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

A Dramatic Improvement in Care for Some People with Cystic Fibrosis
Years of research led to a new medication to overcome the fundamental molecular flaw in some people with cystic fibrosis, greatly reducing their symptoms. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Discoveries May Improve Treatment of Mucopolysaccharidosis
Binding therapeutic enzymes that can cross the blood-brain barrier and use of anti-inflammatory drugs may improve treatment of mucopolysaccharidosis symptoms. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Mouse Model Provides New Insight into Bladder Control
Scientists discovered a protein in the urothelium of mice that helps them control their bladders which could lead to treatments for human urinary incontinence. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

New Function Identified for Odor Receptors
Scientists discovered seven transmembrane receptors in mice that are sensitive to gut microbial metabolism and the regulation of blood pressure. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Deterioration in Heart Function Associated with Progression to Kidney Failure
As patient's progress from chronic kidney disease to kidney failure, ventricular hypertrophy was stable but the heart ’s ejection fraction efficiency decreased. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

A Closer Look at Kidney Structure
Helium ion scanning microscopy, an innovation in imaging, was used to take the most detailed pictures of the glomerulus and other kidney structures to date. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Protein on Surface of Beta Cells Is Possible Type 2 Diabetes Drug Target
When activated, a protein on the insulin producing cells in the pancreas of mice, increased cell number and functioning may help combat type 2 diabetes. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

NIH highlights lifelong impact of acute kidney injury
(Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Improving Blood Stem Cell Transplantation
A combination of drugs increases the number of blood stem cells released by bone marrow into circulation and could help patients recover after chemotherapy. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Surgically Remodeling the Intestines —and the Bacteria Within—To Treat Obesity
A type of bacteria that flourishes in the gut after gastric bypass surgery contributes to weight loss even when transplanted to a gut that has not had surgery. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Connecting Food, Genes, and Rare Metabolic Diseases
Scientists found genes in worms whose activity changes based on diet. Some of these genes are shared by humans and are associated with metabolic diseases. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Weight Loss and Increased Fitness Slow the Decline of Mobility in Adults
A program for weight loss and fitness can slow the decline in physical mobility among adults with type 2 diabetes versus a diabetes support and education group. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Mutations May Lead to Both Kidney and Blood Diseases
A recently discovered set of gene mutations may be behind some cases of the serious blood disorder hemolytic uremic syndrome (HUS). (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Increased Understanding of Cardiovascular Disease Risk Factors in Youth with Type 1 Diabetes
Children with type 1 diabetes and poor blood glucose control were more likely to have thickening of the neck arteries that can lead to cardiovascular disease. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

“The Biggest Loser” Study Predicts Sustained Weight Loss Through Modest Changes in Diet and Exercise
A computer model developed using data from an extreme weight loss program for obese adults found diet more responsible for losing body fat compared to exercise. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news