Vitamin E helps diminish a type of fatty liver disease in children
A specific form of vitamin E improved the most severe form of fatty liver disease in some children, according to a study funded by the NIH. Results appear in the April 27 issue of theJournal of the American Medical Association. A previous study found vitamin E effective in some adults with the disease. (Source: NIDDK News)
Source: NIDDK News - September 10, 2018 Category: Endocrinology Source Type: news

New tool reveals insights into maturation of red blood cells
Using detailed genetic data along with a recently developed analytical tool called “population balance analysis” (PBA), investigators have developed models capable of predicting the mature blood cell type of early stage (progenitor) blood cells.  (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news

Gut microbe helps program immune cells via dietary metabolites
Scientists have identified an important role for a gut bacterial species and its metabolites in the maturation of a key immune cell.  (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news

Health benefits of intensive blood pressure control outweigh a slight risk of developing kidney disease
A new study found that in people who do not have chronic kidney disease (CKD), an intensive blood pressure control regimen increases risk of declining kidney function; this risk is generally outweighed by a reduced risk for cardiovascular events and death. (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news

New insights on risk factors for severe hypoglycemia in people with type 2 diabetes
Results of NIDDK-supported research have improved understanding of factors that can help predict vulnerability to severe hypoglycemia in African American and white individuals with type 2 diabetes. (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news

Understanding how cells in the pancreas change with age
Researchers have used sophisticated technologies to examine individual cells from healthy human pancreata to understand how the cells change with age. (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news

A tale of two sugars —fructose and glucose cause differing metabolic effects
Researchers have found that the sugars fructose and glucose cause different metabolic effects and health outcomes in mice, but only in animals eating a high-fat diet.  (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news

Restricted feeding leads to metabolic benefits in mice
Scientists found that feeding mice twice a day, with complete food restriction in between, improved metabolism and prevented age- and obesity-associated metabolic defects compared to allowing them 24-hour access to food.  (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news

Bacterial enzyme implicated in inflammatory bowel disease
Using human samples and animal models, researchers have found that an enzyme produced by certain bacteria could disrupt the gut microbiome, potentially playing a significant role in the development of inflammatory bowel disease. (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news

Turning pancreatic alpha cells into insulin-producing beta-like cells via gene therapy
Scientists have developed a new way to replace lost beta cells in mouse models of type 1 diabetes.  (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news

Microbial “irony”—bacteria provide keys to battling urinary tract infections
Researchers have identified two different molecules that can limit growth of microbes that cause urinary tract infections (UTIs), adding to approaches being pursued to develop new strategies for clinical treatment of UTIs.  (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news

Genes newly associated with body weight
Scientists ’ recent analysis of hundreds of thousands of human genomes has identified new links between certain gene sequence variations and body mass index (BMI), a measure of weight relative to height. (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news

“Sensing” a genetic predisposition to obesity
New research suggests a mechanism by which antenna-like sensory projections, called primary cilia, located on brain cells play a role in the genetic predisposition to and development of obesity. (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news

Becoming unglued: how a genetic variant may affect the gut barrier and contribute to inflammatory bowel disease
Researchers have found that a genetic variant may impart risk for inflammatory bowel disease (IBD) by disrupting the cellular “glue” that keeps the gut’s lining intact.  (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news

Shedding Light on the Functional Genetic Architecture of Inflammatory Bowel Disease
Recent findings have uncovered two genetic variants that increase the risk for inflammatory bowel disease and also provided clues to their function. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Finding the Genetic Cause of a Form of Hyperparathyroidism
Researchers have identified genetic differences that can cause familial isolated hyperparathyroidism. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

The Sweet Smell of Success —A Protein in the Kidney Helps the Body Retain Sugar
Scientists identified a protein in the mouse kidney that helps prevent the body from excreting glucose. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Dynamic Bladder and Bacterial Changes Hold Clues to Therapies
In two recent studies, researchers delved into changes that occur in the bladder and invading bacteria that affect both acute and recurrent infection. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Large-scale Human Genetics Study of Fat Depots Identifies Gene Regions Associated with Depot- and Gender-specific Fat Cell Development
The largest-scale human genetics study of its kind has identified seven new gene regions associated with individual variability in body fat. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Donor Outcomes in the Years After Living Donor Liver Transplantation
Studies provide a more complete picture of how living donor liver transplantation affects donors in a myriad of ways. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Identification of Signaling Pathway Involved in Diabetic Nerve Damage Leads to Discovery of Promising New Therapy
Blocking a signaling pathway involved in diabetic nerve damage could prevent or reverse that damage in mice. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Elucidating Complex Interactions Between Human Gut Microbes, Diet, and Response
Research is illuminating the multiple levels of complex interactions that contribute to how human gut microbes affect health. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

A Strategy for Synthesizing Potential New Drugs and Research Tools Yields Insights into Fat Cell Development
Researchers developed a set of small chemicals that bind many different proteins in cells and can be used to learn the proteins ’ functions. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Story of Discovery —Intestinal Stem Cells
The discovery of intestinal stem cells, the ancestors to all other cells in the intestinal epithelium, has led to prolific research into the complex dynamics that regulate the development and turnover of the intestinal lining. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Story of Discovery —Artificial Pancreas for Managing Type 1 Diabetes: Cutting-edge Technology 50 Years in the Making
With support from NIDDK, private funding entities, and industry, researchers have created a revolutionary new management tool for type 1 diabetes. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Story of Discovery —APOL1 Gene Variants: Unraveling the Genetic Basis of Elevated Risk for Kidney Disease in African Americans
Identification ofAPOL1 kidney disease genetic risk variants, found primarily in African Americans, is arguably the most important discovery about the pathogenesis of chronic kidney disease over the past few decades. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Immune Molecule Defends Against Bacterial Infection by Withholding Iron
An international group of researchers has found, in a mouse model, one way in which the body thwarts infection by pathogenic bacteria: limiting availability of iron. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

New Treatment Prevents Formation of Cystine Stones, a Type of Kidney Stone, in Mice
The antioxidant α-lipoic acid was shown to prevent the formation of cystine stones in mice. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Brain Control of Obesity-related Behaviors
Studies have demonstrated new links between nerve cell activity in specific brain regions and both physical activity and the drive to eat. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Signals from Body Fat to Other Organs —Small Packages with Big Metabolic Impact
Researchers discovered a new way that fat tissue regulates metabolism. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

An Appetite-suppressing Hormone in Bones
Researchers discovered that bones secrete a hormone that suppresses appetite and regulates blood glucose levels. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Seeking a Genetic Signature for Urinary Tract Infections
A complex and dynamic interplay betweenE. coli strains and their host environment determines infection and subsequent disease. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Possible New Trigger for Recurrent Urinary Tract Infections Identified
Researchers identified a naturally occurring component of the vaginal microbiota as a possible trigger of recurrent urinary tract infections and a subsequent kidney infection. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Uncovering Factors Linked to Celiac Disease
Recent studies provide important insight into celiac disease ’s prevalence and a possible trigger for the disease in genetically susceptible people. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Insights into Salt Handling, Water Balance, and Blood Pressure Regulation by the Kidneys
Two studies in mice have shed light on the complex relationships between kidney physiology, salt intake, water balance, and hypertension. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Adherence to Immunosuppressive Medication Leads to Better Outcomes in Young Liver Transplant Recipients
A study of children who received liver transplants found that adherence to taking immunosuppressive medication can predict organ rejection later. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Innovations in Testing for a Rare Genetic Disease —Pompe Disease
Researchers have developed methods that could significantly improve accuracy of testing for a rare genetic disorder. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Kidney Damage from High Blood Pressure Leads to New Lymphatic Vessel Formation
Researchers examined the effects of hypertension on lymphatic vessels, which drain fluid, immune cells, and waste products away from tissues. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Correcting Iron-delivery Defects in Animals
Small molecule compound identified that may be able to supply iron where it is needed without interfering with other cell functions. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Small, Yet Powerful Mitochondria and Blood Stem Cells
Recent studies of blood stem cells highlight the importance of cellular components called mitochondria in determining how these cells function. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Identification of Brain Cells That Drive Binge Eating and Weight Gain
Researchers have identified a group of brain cells that can induce rapid binge eating and weight gain in mice. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Novel Insights into Present and Future Pain in People with Urologic Pain Syndromes
Two recent reports have revealed important new information about pain patterns and detecting future pain trends through noninvasive brain imaging. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Measuring How Well the Kidney Works —One “Nephron” at a Time
Scientists developed a new method for calculating the average rate that a single kidney nephron filters blood —an important measure of kidney health. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

A Weight-loss Intervention Shows Promise for Low-income Mothers Post-childbirth
An Internet-based weight loss intervention produces greater weight loss in these women than a standard care program alone. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Predicting Kidney Function Decline in People Who Are at High Risk for Kidney Disease
Levels of a protein in the blood can help predict whether kidney function will deteriorate in people with high-risk genetic variants of the geneAPOL1. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Identification of a Key Metabolic Regulator
The protein β-arrestin-2 plays critical roles in the pancreas and liver to regulate metabolism. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Brain Immune Cells Control Food Intake and Obesity
Researchers have discovered that a type of brain immune cell, called microglia, controls food intake and obesity in mice. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Mouse Models of Liver Disease Highlight Important Roles of Temperature and Sex
Recent studies demonstrate the importance of factors such as the sex of the animals and even their living temperature in designing experiments. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Urinary Tract Infection Vaccines —Putting Metal to the Pedal
Study results point toward an additional pool of candidate targets for vaccines to prevent urinary tract infections (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Cellular Understanding of How the Brain Controls Aging
Researchers have discovered cellular mechanisms by which the brain regulates aging in mice (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news