The Efficacy of Famotidine in improvement of outcomes in Hospitalized COVID-19 Patients: A structured summary of a study protocol for a randomised controlled trial
This study aims to investigate the effect of Famotidine on the recovery process of COVID-19 patients.Trial designThis phase III randomized clinical trial was designed with two parallel arms, placebo-controlled, single-blind, and concealed allocation.ParticipantsAll COVID-19 patients admitted to Shahid Mohammadi Hospital in Bandar Abbas whose PCR test results are positive for SARS-Cov-2 and sign the written consent of the study are included in the study and immunocompromised patients, end-stage renal disease, moderate renal failure (clearance Creatinine 30 to 50 ml/min) or stage 4 severe chronic kidney disease or need for d...
Source: Trials - October 13, 2020 Category: Research Source Type: clinical trials
Protecting Frontline Health Care Workers from COVID-19 with Hydroxychloroquine Pre-exposure Prophylaxis: A structured summary of a study protocol for a randomised placebo-controlled multisite trial in Toronto, Canada
AbstractObjectivesPrimary Objective: To determine if pre-exposure prophylaxis (PrEP) with 400mg hydroxychloroquine (HCQ), taken orally once daily reduces microbiologically confirmed COVID-19 among front line health care workers at high risk for SARS-CoV-2 exposure.Secondary Objectives: To compare the following between study arms: adverse events; symptomatic COVID-19; duration of symptomatic COVID-19; days hospitalized attributed to COVID-19; respiratory failure attributable to COVID-19 requiring i) non-invasive ventilation or ii) intubation/mechanical ventilation; mortality attributed to COVID-19, number of days unable to ...
Source: Trials - July 13, 2020 Category: Research Source Type: clinical trials
Expanded Access Protocol of Givosiran for Patients With Acute Hepatic Porphyria
Condition: Acute Hepatic Porphyria Intervention: Drug: Givosiran Sponsor: Alnylam Pharmaceuticals Available (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 14, 2019 Category: Research Source Type: clinical trials
