Hemorrhage induced by antithrombotic agents: new insights from a real-world pharmacovigilance study
CONCLUSION: We found that the risk of bleeding in patients taking Crude low molecular weight heparins was significantly higher compared to other antithrombotic agents, but with a small magnificence, which may be attributed to the severely irrational use of this medication under improper management. Statistics in days, results showed that the risk of bleeding decreased over time for warfarin and clopidogrel and increased for alteplase, nadroparin, and dipyridamole.PMID:38497691 | DOI:10.1080/14740338.2024.2327502 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - March 18, 2024 Category: Drugs & Pharmacology Authors: Kangyuan Guo Ganyi Wang Li Zhang Zhanchun Feng Xudong Xia Xiaobo Sun Ziqi Yan Zhiming Jiao Da Feng Source Type: research
Contribution of platelets to disruption of the blood-brain barrier during arterial baroreflex dysfunction
CONCLUSION: During ABR dysfunction, platelets may disrupt the blood-brain barrier when CD40L on their surface activates NF-kB signaling within cerebral microvascular endothelial cells, leading to upregulation of matrix metalloprotease-9. Our findings imply that targeting CD40L may be effective against cerebral diseases involving ABR dysfunction.PMID:38493885 | DOI:10.1016/j.mvr.2024.104681 (Source: Cell Research)
Source: Cell Research - March 17, 2024 Category: Cytology Authors: Bowen Shen Lili Yang Xiaoli Jia Deping Kong Yongfeng Gao Shan Gao Ruimin Chen Fengbao Chen Chunyu Zhao Yue Li Rui Tan Xiaomin Zhao Source Type: research
Antithrombotic strategies for preventing graft failure in coronary artery bypass graft
This article aims to inform clinical decision-making and guide the selection of antithrombotic strategies after CABG. (Source: Journal of Thrombosis and Thrombolysis)
Source: Journal of Thrombosis and Thrombolysis - March 16, 2024 Category: Hematology Source Type: research
Relationship between in-stent restenosis following carotid artery stenting and platelet reactivity to clopidogrel
CONCLUSIONS: High PRU (≥220) and low IR (≤14.5%) are related to ISR R3 following CAS, which may cause ipsilateral ischemic stroke.PMID:38490734 | DOI:10.1136/jnis-2024-021445 (Source: Atherosclerosis)
Source: Atherosclerosis - March 15, 2024 Category: Cardiology Authors: Min-Yong Kwon Sang Hyo Lee Yongjae Lee Young Deok Kim Si Un Lee Jae Seung Bang O-Ki Kwon Chang Wan Oh Seung Pil Ban Source Type: research
Relationship between in-stent restenosis following carotid artery stenting and platelet reactivity to clopidogrel
CONCLUSIONS: High PRU (≥220) and low IR (≤14.5%) are related to ISR R3 following CAS, which may cause ipsilateral ischemic stroke.PMID:38490734 | DOI:10.1136/jnis-2024-021445 (Source: Atherosclerosis)
Source: Atherosclerosis - March 15, 2024 Category: Cardiology Authors: Min-Yong Kwon Sang Hyo Lee Yongjae Lee Young Deok Kim Si Un Lee Jae Seung Bang O-Ki Kwon Chang Wan Oh Seung Pil Ban Source Type: research
Viruses, Vol. 16, Pages 450: Small Molecules for the Treatment of Long-COVID-Related Vascular Damage and Abnormal Blood Clotting: A Patent-Based Appraisal
iano Altomare
People affected by COVID-19 are exposed to, among others, abnormal clotting and endothelial dysfunction, which may result in deep vein thrombosis, cerebrovascular disorders, and ischemic and non-ischemic heart diseases, to mention a few. Treatments for COVID-19 include antiplatelet (e.g., aspirin, clopidogrel) and anticoagulant agents, but their impact on morbidity and mortality has not been proven. In addition, due to viremia-associated interconnected prothrombotic and proinflammatory events, anti-inflammatory drugs have also been investigated for their ability to mitigate against immune dysregulation du...
Source: Viruses - March 14, 2024 Category: Virology Authors: Francesco Samarelli Giovanni Graziano Nicola Gambacorta Elisabetta Anna Graps Francesco Leonetti Orazio Nicolotti Cosimo Damiano Altomare Tags: Perspective Source Type: research
Development of a routine bedside CYP2C19 genotype assessment program for antiplatelet therapy guidance in a community hospital catheterization laboratory
Abstract Genotype based personalized antiplatelet therapy in the setting of percutaneous coronary intervention (PCI) has been studied in clinical trials. Despite the demonstrated risk associated withCYP2C19 loss-of-function(LoF) carriage in clopidogrel-treated PCI patients, real-world implementation of genotyping for PCI has been low. The goal of the current study was to provideCYP2C19 genotype information to the interventionalist prior to the completion of the catheterization to facilitate immediate personalized antiplatelet therapy. Routine personalization of P2Y12 inhibitor therapy for PCI in a community hospital cardia...
Source: Journal of Thrombosis and Thrombolysis - March 13, 2024 Category: Hematology Source Type: research
Inclusivity in randomised clinical trials: myth or reality?
In this issue of Heart, Castelijns et al aimed to apply the inclusion and exclusion criteria from the Cardiovascular Outcomes for People Using Anticoagulation Strategies, Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance trials, Prevention of Cardiovascular Events in Patients with Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction and Dual Antiplatelet Therapy to patients included in the Utrecht Cardiovascular Cohort-Second Manifestations of Arterial Disease. The study aims to evaluate the applicability in th...
Source: Heart - March 12, 2024 Category: Cardiology Authors: Iannaccone, M., Gamardella, M., Chieffo, A. Tags: Editorials Source Type: research
Generalisability of trials on antithrombotic treatment intensification in patients with cardiovascular disease
Conclusion
A large proportion of contemporary CVD patients would be eligible for intensified antithrombotic treatment trials, with mostly similar adjusted event risks to ineligible patients. Trial-based guideline recommendations are largely applicable to real-world patients. (Source: Heart)
Source: Heart - March 12, 2024 Category: Cardiology Authors: Castelijns, M. C., Hageman, S. H. J., Teraa, M., van der Meer, M. G., Westerink, J., ten Berg, J., Visseren, F. L. J. Tags: Aortic and vascular disease Source Type: research
Antiplatelet Treatment Preferences of a Group of Cardiologists from T ürkiye: A Survey Research Study
CONCLUSION: The aim of this survey to capture a snapshot of the preferences of a group of cardiologists in Türkiye regarding DAPT treatment and duration. The responses were both in accordance and in conflict with the current guidelines.PMID:38465531 | DOI:10.5543/tkda.2023.54778 (Source: Turk Kardiyoloji Dernegi arsivi)
Source: Turk Kardiyoloji Dernegi arsivi - March 11, 2024 Category: Cardiology Authors: Özge Çetinarslan Mustafa Yener çağ Mehdi Zoghi As ım Oktay Ergene Source Type: research
