Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Effect of Ticagrelor versus Clopidogrel on All-Cause and Cardiovascular Mortality in Acute Coronary Syndrome Patients with Hyperuricemia
ConclusionHyperuricemia was independently related to an increased risk of all-cause and cardiovascular death in patients with ACS undergoing PCI. At 1-year follow-up, there were no significant differences between ticagrelor and clopidogrel concerning all-cause and cardiovascular death in patients with hyperuricemia. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - February 7, 2024 Category: Drugs & Pharmacology Source Type: research
Do the guidelines guide the belgrade emergency medical service physicians through the management of acute st-elevation myocardial infarction?
Acta Clin Croat. 2023 Apr;62(1):123-130. doi: 10.20471/acc.2023.62.01.15.ABSTRACTThe aim of the study was to assess whether current guidelines for diagnosis and treatment of acute ST-elevation myocardial infarction (STEMI) in daily clinical practice are adequately applied in the Belgrade Emergency Medical Service (EMS). A retrospective research included 2,982 STEMI patients who were cared for by EMS teams. Therapy consisting of morphine, oxygen, nitroglycerin and aspirin (MONA) was applied. Dual antiaggregation therapy (aspirin 325 mg + ticagrelor 180 mg or clopidogrel 600 mg) was administered to patients with primary perc...
Source: Acta Clinica Croatica - February 2, 2024 Category: General Medicine Authors: Goran Čolaković Sla đana Anđelić Sne žana Bogunović Nata ša Čolaković Source Type: research
