Peyronie's Disease Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Penile plication for peyronie's disease: the iterative 8-dot technique
Penile plication is a minimally invasive and effective technique for managing mild to severe curvature from Peyronie's disease. (Source: Urology)
Source: Urology - March 14, 2022 Category: Urology & Nephrology Authors: Alysen Demzik, Mark Ehlers, Jake Brems, Bradley Figler Source Type: research

Whole-Genome Sequencing Identifies Novel Heterozygous Mutation in ALMS1 in Three Men with Both Peyronie's and Dupuytren's Disease
Peyronie's Disease (PD) is estimated to occur in up to 13% of males and has been associated with Dupuytren's Disease (DD). We identified three men with PD/DD and hypothesized that there may be a genetic association between the two diseases. Blood samples were collected from the participants and sent for whole genome sequencing. A rare non-synonymous mutation in the ALMS1 gene was identified in three men. Interestingly, ALMS1 is associated with TGF-b and aberrant fibrosis. This pilot study generates the hypothesis that mutations in ALMS1 may predispose patients to development of PD/DD. (Source: Urology)
Source: Urology - March 11, 2022 Category: Urology & Nephrology Authors: Alexandra Dullea, Iakov Efimenko, Fakiha Firdaus, Anthony Griswold, Himanshu Arora, Thomas Masterson, Ranjith Ramasamy Source Type: research

Pharmacotherapy in Peyronie's disease: a state-of-the-art review on established contemporary and emerging drugs
This article examines the current understanding of established contemporary and emerging pharmacotherapies for PD. Emphasis has been placed on published clinical studies on drugs in the last 10 years.EXPERT OPINION: Published studies have shown that combination therapy is likely more effective than monotherapy. Combined treatment modalities involving various oral and/or intralesional pharmacotherapies together with mechanical devices or clinical psychosexual therapy may provide additional or synergistic benefits for PD patients. A multidisciplinary approach coupled with more novel targets for pharmacological intervention c...
Source: Expert Opinion on Pharmacotherapy - February 25, 2022 Category: Drugs & Pharmacology Authors: Eric Chung Faysal A Yafi Source Type: research

Editorial comment
Penile “hourglass” deformity (PHD) is a rare condition that affects about 1% of patients with Peyronie's disease.1 PHD develops from the Peyronie's disease plaque and the tunica albuginea retraction due to the inflammatory process. The final aspect of a penis during tumescence consists of a “clepsydr a” shaped shaft and a subsequent psychological and functional impact on the relational life of the patients.2 Erectile dysfunction was reported in 61% – 68% of the patients although it is not clear if this dysfunction could be considered as psychologically or anatomically related. (Source: Urology)
Source: Urology - December 1, 2021 Category: Urology & Nephrology Authors: Riccardo Bartoletti, Girolamo Morelli, Alessandro Zucchi Source Type: research

Author reply
After years of emphasizing only penile straightening procedures in our Peyronie's reconstruction cases, our patients have taught us that penile concavity deformities (notching and hourglass) are often just as troubling. The extra-tunical grafting (ETG) technique is a promising innovation for addressing these deformities and our series is only the second known published series on the technique. Preservation of the tunica albuginea avoids disruption of the veno-occlusive apparatus at the area of grafting, thus likely lowering the risk of complications. (Source: Urology)
Source: Urology - December 1, 2021 Category: Urology & Nephrology Authors: Linley Diao, Allen F. Morey Source Type: research

Technological Advancements for Treating Erectile Dysfunction and Peyronie's Disease
Urol Clin North Am. 2022 Feb;49(1):175-184. doi: 10.1016/j.ucl.2021.07.013. Epub 2021 Oct 22.ABSTRACTOver the past decade, there have been several advancements in the technologies available to treatment erectile dysfunction and Peyronie's disease. Vacuum erection devices, penile traction devices, low-intensity extracorporeal shockwave therapy, and penile prosthesis surgery have evolved and are changing the way we treat men's health. Although significant improvements have been made, further work is needed to standardize treatment, create universal algorithms for technological applications, and simply their use.PMID:34776050...
Source: The Urologic Clinics of North America - November 15, 2021 Category: Urology & Nephrology Authors: Jeffrey D Campbell Danny Matti Haider Abed Andrew Di Pierdominico Source Type: research