Innate allergy
Immunology Interest Group Seminar Series
Despite clear roles for classical arms of immunity in maintenance of a healthy commensal microbial flora and protection from invasive pathogenic organisms, the purpose of allergic immunity, which underlies increasingly prevalent diseases like food allergy, asthma and atopic dermatitis, remains puzzling. The discovery of innate lymphoid cells that are programmed to produce cytokines associated with allergic immunity has provided new opportunities to assess basal physiologic processes that involve this canonical tissue response, and may reveal opportunities for re-tuning this arm of i...
Source: Videocast - All Events - March 30, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Is the Right Flavor of Inflammation the Key to Successful Cancer Therapy?
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Romina Goldszmid received her Ph.D. working on dendritic cell-based vaccines for melanoma immunotherapy from the University of Buenos Aires, Argentina, part of which was performed as a visiting scholar in the laboratory of Dr. Ralph Steinman at the Rockefeller University. She then did her postdoctoral training in infectious diseases immunology with Dr. Alan Sher in the Laboratory of Parasitic Diseases (LPD) at NIAID. There, Dr. Goldszmid focused on the interplay between dendritic cells and natural killer cells during the early response to Toxoplasma gondii infecti...
Source: Videocast - All Events - January 23, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Pi Day: Carlos Bustamante: Models and Data in Biomedicine: What's Real and What's Noise? And, Why Should We Care?
Data Science Distinguished Seminar Series
If you think of a scatterplot of data overlaid with a model for the data and ask practitioners from different fields, “what’s noise and what’s real?” the answers may surprise you. To a biologist, the data will almost surely be “what’s real” and the model is a poor approximation to the “truth.” To a physicist, the model is probably “what’s real” and the data is just a noisy realization of an underlying true physical process that we are attempting to study. As we think about the biomedical data enterprise in the 21st century and the massive amounts of data w...
Source: Videocast - All Events - March 3, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Danger-based immunology course, session seven: parasites
Presented by: polly matzingerCategory: SpecialAired date: 11/09/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - November 11, 2015 Category: Journals (General) Tags: Past Events Source Type: video
Danger-based immunology course, session seven: parasites
This is the seventh session of the immunology course based on the Danger model. in it we will discuss the influence of parasites on immune responses. as alan sher puts it, parasites and pathogens are the best immunologists, having had evolutionary time to figure us out.Air date: 11/9/2015 1:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 6, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
New National Academy of Sciences Members Minisymposium
A mini-symposium featuring NIH's three newest investigators elected to the National Academy of Sciences: Carolina Barillas-Mury (NIAID), Marius Clore (NIDDK), and Shiv Grewal (NCI). Each will speak about their latest research.
Barillas-Mury is chief of the Mosquito Immunity and Vector Competence Section in the NIAID Laboratory of Malaria and Vector Research. She investigates the interactions between the mosquito immune system and Plasmodium parasites to understand how they affect malaria transmission. Clore is an NIH Distinguished Investigator in the NIDDK Laboratory of Chemical Physics. His lab is develo...
Source: Videocast - All Events - June 13, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
Genetic Basis of Protozoan Pathogan Emergence and Disease
Presented by: Michael Grigg, Ph.D. Chief, Molecular Parasitology Section, Laboratory of Parasitic Diseases, NIAID, NIH Category: NIH Director's SeminarsAired date: 03/07/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - March 11, 2014 Category: Journals (General) Tags: Past Events Source Type: video
Genetic Basis of Protozoan Pathogan Emergence and Disease
NIH Director's Seminar
Dr. Grigg’s research program investigates the emergence and pathogenesis of prevalent zoonoses that infect a broad spectrum of animal and human hosts. His group is particularly focused on the protozoan parasites Toxoplasma, Leishmania, Giardia, and Cryptosporidium. He performs population and molecular genetic analyses, using both forward and reverse genetics, to identify virulence genes that control pathogenesis and perturb immune system homeostasis in animal models of natural infection. Recent work is exploring the extent to which protozoan parasites utilize their sexual cycles to rapidly produce...
Source: Videocast - All Events - March 4, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
Discovery of Vaccine and/or Drug Targets in Plasmodium Falciparum using Irradiated Long-Lived Merozoites
Development of a malaria vaccine, as well as, new drugs is crucial for the future control of Plasmodium falciparum, the most severe form of human malaria causing nearly a million deaths each year. Unfortunately, no licensed malaria vaccine is available and development of drug resistant parasites is a continual problem. To provide future opportunities for development, we aimed to identify the phenotypic difference(s) between a novel irradiated P. falciparum long-lived merozoite line and its parental line that displays up to a 20 fold increase in erythrocyte invasion rates, in vitro. Using the tools of systems biology, t...
Source: Videocast - All Events - October 28, 2013 Category: Journals (General) Tags: Upcoming Events Source Type: video
Illumination of innate and adpative immunity in the brain
NIH Director's Seminar Series
Immune responses are highly dynamic and often shaped by the tissue in which they develop. The Viral Immunology and Intravital Imaging Unit is interested in defining the mechanics of innate and adaptive immune responses in living tissues. To accomplish this, we use a real-time imaging technique referred to as two-photon laser scanning microscopy. This approach enables us to peer into lymphoid and non-lymphoid tissues as they experience different immunological perturbations. We are particularly interested in understanding the dynamics of immune responses that develop to infections (viruses,...
Source: Videocast - All Events - February 1, 2013 Category: Journals (General) Tags: Upcoming Events Source Type: video
