A multi-centre randomised trial to compare the effectiveness of geriatrician-led admission avoidance hospital at home versus inpatient admission
DiscussionHealth systems around the world are examining how to provide acute hospital-level care to older adults in greater numbers with a fixed or shrinking hospital resource. This trial is the first large multi-site randomised trial of geriatrician-led admission avoidance hospital at home, and will provide evidence on alternative models of healthcare for older people who require hospital admission.Trial registrationISRCTN60477865: Registered on 10 March 2014. Trial Sponsor: University of Oxford. Version 3.1, 14/06/2016. (Source: Trials)
Source: Trials - October 23, 2017 Category: Research Source Type: clinical trials
iTACTIC – implementing Treatment Algorithms for the Correction of Trauma-Induced Coagulopathy: study protocol for a multicentre, randomised controlled trial
DiscussionCCTs have traditionally been used to detect TIC and monitor response to treatment in traumatic major haemorrhage. The use of VHAs is increasing, but limited evidence exists to support the superiority of these technologies (or comparatively) for patient-centred outcomes. This knowledge gap will be addressed by this trial.Trial registrationClinicalTrials.gov, ID:NCT02593877. Registered on 15 October 2015.Trial sponsorQueen Mary University of LondonThe contact person of the above sponsor organisation is: Dr. Sally Burtles, Director of Research Services and Business Development, Joint Research Management Office, QM I...
Source: Trials - October 18, 2017 Category: Research Source Type: clinical trials
Merck Announces Results of REVEAL Outcomes Study of Anacetrapib, Investigational Medicine for Cardiovascular Disease
KENILWORTH, N.J.--(BUSINESS WIRE) August 29, 2017 --Merck (NYSE:MRK), known as MSD outside the U.S. and Canada, and researchers in the Clinical Trial Service Unit at the University of Oxford, today announced the publication and presentation of... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - August 29, 2017 Category: Pharmaceuticals Source Type: clinical trials
Effects of digital Cognitive Behavioural Therapy for Insomnia on cognitive function: study protocol for a randomised controlled trial
This study specifically aims to (1) investigate the impact of CBT-I on cognitive functioning, assessed through both self-reported impairment and objective performance measures, and (2) examine whether change in sleep mediates this impact.Methods/designWe propose a randomised controlled trial of 404 community participants meeting criteria for Insomnia Disorder. In the DISCO trial (Defining theImpact of improvedSleep onCOgnitive function (DISCO)) participants will be randomised to digital automated CBT-I delivered by a web and/or mobile platform (in addition to treatment as usual (TAU)) or to a wait-list control (in addition...
Source: Trials - June 17, 2017 Category: Research Source Type: clinical trials
Assessment of Efficacy of Mirabegron, a New beta3-adrenergic Receptor in the Prevention of Heart Failure
Condition: Hypertrophy, Left VentricularInterventions: Drug: mirabegron; Procedure: Echocardiography; Procedure: Cardiac MRI; Procedure: Maximal exercise capacity; Procedure: Blood sampling; Procedure: Endothelial function measurement; Radiation: 18FDG-PETSponsors: Jean-Luc Balligand; Zentrum für Klinische Studien Leipzig (ZKS Leipzig); European Clinical Research Infrastructure Network (ECRIN); European Society of Cardiology; European Commission; Cliniques universitaires Saint-Luc- Université Catholique de Louvain; The Northern Lisbon Hospital Center –...
Source: ClinicalTrials.gov - October 30, 2015 Category: Research Source Type: clinical trials
