Investigating Distinct and Overlapping Mechanisms in TDP-43 Proteinopathies, including in LATE, FTD and other ADRDs (R01 - Clinical Trial Not Allowed)
Funding Opportunity PAR-23-212 from the NIH Guide for Grants and Contracts. This FOA would support establishing deeper mechanistic insight and causal relationships between TDP-43 pathology and phenotypic outcomes, as well as mechanistic interactions between TDP-43 and other co-pathologies, such TMEM106B. Additionally, it would include comparisons (including mechanistic, molecular, structural, cellular, genetic, -omic, anatomical, neuropathological, etc.) between TDP-43 proteinopathies, including LATE, with or without AD-NC, and FTD and/or ALS. (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - May 23, 2023 Category: Research Source Type: funding
Mechanistic Investigations into ADRD Multiple Etiology Dementias (R01 - Clinical Trial Not Allowed)
Funding Opportunity PAR-23-211 from the NIH Guide for Grants and Contracts. This FOA would support investigations with a minimum of two relevant co-pathologies (e.g., tau, alpha-synuclein, TDP-43, TMEM106B, vascular), with optional risk factors and co-morbidities, to identify cellular and molecular mechanisms of how/why multi-proteinopathy interactions drive worsening neurodegenerative processes and phenotypic outcomes. Studies should examine co-pathology cellular and molecular interactions across brain regions and time in proximate cell population, across various intracellular dynamics and localization, and upstream an...
Source: NIH Funding Opportunities (Notices, PA, RFA) - May 23, 2023 Category: Research Source Type: funding
Notice of Change to Application and Submission Information for RFA-NS-23-026 "BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed)"
Notice NOT-NS-23-086 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - May 23, 2023 Category: Research Source Type: funding
Assessment of TBI-related ADRD Pathology Related to Cognitive Impairment and Dementia Outcomes (U01 - Clinical Trial Not Allowed)
Funding Opportunity RFA-NS-24-003 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites applications for a multisite study to comprehensively characterize ADRD relevant pathology related to cognitive impairment and dementia outcomes in persons with a history of traumatic brain injury (TBI). Investigations should elucidate the contribution of key individual (sex, age at time of injury, time since injury, social determinants of health, etc.) and injury characteristics (injury severity and frequency) to describe associations between neuropathological burden and antemortem clinicopat...
Source: NIH Funding Opportunities (Notices, PA, RFA) - May 19, 2023 Category: Research Source Type: funding
Advancing Psychedelics Research for Treating Addiction (R61/R33 Basic Experimental Study with Humans Required)
Funding Opportunity RFA-DA-24-029 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to use multidisciplinary approaches to advance basic and clinical research and address key knowledge gaps on psychedelics. Given the therapeutic promise that psychedelics hold as neurotherapeutics, the goal is to systematically evaluate, and understand their mechanism of action and drug-target engagement, along with other translational aspects including their safety, pharmacokinetics/pharmacodynamics, and efficacy, in the context of substance use disorders (SUD). (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - May 16, 2023 Category: Research Source Type: funding
Advancing Psychedelics Research for Treating Addiction (R01 Clinical Trial Not Allowed)
Funding Opportunity RFA-DA-24-028 from the NIH Guide for Grants and Contracts. The overarching goal of this NIDA Notice of Funding Opportunity (NOFO) is to elucidate and validate the molecular, cellular, circuitry and structural mechanisms and pathways that underly the pharmacology of psychedelic compounds for treating substance use disorders (SUDs) and related psychiatric and neurological co-morbidities. This NOFO will also support the design and synthesis of chemical probes to provide mechanistic insights on biological targets modulated by psychedelics, and on common targets/pathways in the context of SUD. Research su...
Source: NIH Funding Opportunities (Notices, PA, RFA) - May 16, 2023 Category: Research Source Type: funding
Advancing Psychedelics Research for Treating Addiction (R61/R33 Clinical Trial Required)
Funding Opportunity RFA-DA-24-024 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to use multidisciplinary approaches to advance basic and clinical research and address key knowledge gaps on psychedelics. Given the therapeutic promise that psychedelics hold as neurotherapeutics, the goal is to systematically evaluate, and understand their mechanism of action and drug-target engagement, along with other translational aspects including their safety, pharmacokinetics/pharmacodynamics, and efficacy, in the context of substance use disorders (SUD). (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - May 16, 2023 Category: Research Source Type: funding
Emergency Medicine Research Career Development Program in the Neurological Sciences (EMRCDP-NS) (K12 - No Independent Clinical Trial Allowed)
Funding Opportunity PAR-23-151 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to invite applications to support a national program of mentored research career development for junior emergency medicine faculty at institutions nationwide that support emergency medicine physicians to conduct research. The goal of the program is to expand the cadre of emergency medicine investigators trained to conduct research into neurological disorders, which makes use of their expertise associated with their clinical experience as emergency medicine clinicians. (Source: NIH Fun...
Source: NIH Funding Opportunities (Notices, PA, RFA) - May 16, 2023 Category: Research Source Type: funding
Preclinical Studies to Characterize the Impact of Toxicants on Brain Aging and Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (U01 Clinical Trial Not Allowed)
Funding Opportunity RFA-AG-24-023 from the NIH Guide for Grants and Contracts. The central goal of this funding initiative is to evaluate the molecular, pathologic and functional consequences of major toxicants known to be associated with elevated AD/ADRD risk, in mouse models of Late Onset AD (LOAD). Projects funded through this program will examine the consequences of early and mid-life exposure on late-life brain health by conducting cross-sectional/longitudinal multi-modal phenotyping (molecular, biochemical, pathologic and behavioral) of mouse models of LOAD, and the impact of genetic diversity and sex-differences ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - May 15, 2023 Category: Research Source Type: funding
Understanding Gene-Environment Interactions in Brain Aging and Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (U01 Clinical Trial Not Allowed)
Funding Opportunity RFA-AG-24-021 from the NIH Guide for Grants and Contracts. The ?objective of this funding initiative is to stimulate research to gain mechanistic insights into gene-environment (GxE) interactions in response to environmental toxicants using human cell-based models. This RFA will support interdisciplinary research projects that utilize disease relevant human cell-based in vitro and ex vivo models to characterize the effects of gene environment interactions on gene regulation and cellular functions, and to elucidate toxicant mediated molecular and cellular mechanisms in brain aging and AD/ADRD. (Source...
Source: NIH Funding Opportunities (Notices, PA, RFA) - May 15, 2023 Category: Research Source Type: funding
Collaborative Opportunities for Multidisciplinary, Bold, and Innovative Neuroscience (COMBINE) (RM1 Clinical Trial Optional)
Funding Opportunity RFA-NS-23-027 from the NIH Guide for Grants and Contracts. Reissue of RFA-NS-22-011 to comply with DMSP changes. No changes to receipt dates or locus of review. This funding opportunity announcement (FOA) is designed to support integrated efforts of three or more (up to six) PDs/PIs to pursue bold, impactful, and challenging research in any area within the scope of the NINDS mission. The research approach should be interdisciplinary in nature, and the research teams are expected to establish a common goal that requires collaboration, synergy, and managed team interactions. Proposed research should no...
Source: NIH Funding Opportunities (Notices, PA, RFA) - May 15, 2023 Category: Research Source Type: funding
Early-Stage Therapy Development for Alzheimer's Disease-Related Dementias (ADRD) (R61/R33 - Clinical Trial Not Allowed)
Funding Opportunity RFA-NS-24-010 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) encourages early-stage development of novel small molecule or biologic therapeutics for NINDS mission-relevant? Alzheimer's and related dementias: frontotemporal degeneration (FTD, including Picks disease and progressive supranuclear palsy), Lewy body dementias (LBD; including dementia with Lewy bodies (DLB) and Parkinsons disease dementia (PDD), vascular contributions to cognitive impairment and dementia (VCID), and multiple etiology dementias (MED). This FOA covers four stages of early therapy dis...
Source: NIH Funding Opportunities (Notices, PA, RFA) - May 15, 2023 Category: Research Source Type: funding
Evaluating Neurocognitive Complications of Pediatric Type 1 Diabetes (T1D) and Potential Risk and Protective Factors Clinical Centers (U01 Clinical Trial Not Allowed)
Funding Opportunity RFA-DK-23-010 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to establish a clinical consortium to better understand the neurocognitive impact of new onset type 1 diabetes (T1D) in pre-pubertal children. Clinical Centers (CCs) will establish a diverse cohort of pre-pubertal children newly diagnosed with T1D and will evaluate disease-related perturbations in neurocognitive function, as well as identify potential clinical, developmental, and/or environmental factors associated with neurocognitive function in T1D.A separate NOFO (RFA-DK-23-009) w...
Source: NIH Funding Opportunities (Notices, PA, RFA) - May 15, 2023 Category: Research Source Type: funding
Evaluating Neurocognitive Complications of Pediatric Type 1 Diabetes (T1D) and Potential Risk and Protective Factors Biostatistics Research Center (U01 Clinical Trial Not Allowed)
Funding Opportunity RFA-DK-23-009 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites applications for a Biostatistics Research Center (BRC) to participate in a clinical consortium to better understand the neurocognitive impact of new onset type 1 diabetes (T1D) in pre-pubertal children. A separate RFA (RFA-DK-23-010 ) invites Clinical Centers (CCs) to establish a diverse cohort of pre-pubertal children newly diagnosed with T1D and will longitudinally evaluate disease-related perturbations in neurocognitive function, as well as identify potential clinical, developmental, and/or...
Source: NIH Funding Opportunities (Notices, PA, RFA) - May 15, 2023 Category: Research Source Type: funding
BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed)
Funding Opportunity RFA-MH-23-290 from the NIH Guide for Grants and Contracts. This is a reissue of RFA-MH-21-175 to comply with DMSP policy. The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essenti...
Source: NIH Funding Opportunities (Notices, PA, RFA) - May 8, 2023 Category: Research Source Type: funding
