PROACTIVE: Surgical Resection Outcomes in Locally Advanced and Unresectable Pancreatic Cancer After Neoadjuvant Chemotherapy
Conditions: Locally Advanced Pancreatic Adenocarcinoma; Stage III Pancreatic Cancer American Joint Committee on Cancer v8; Unresectable Pancreatic Adenocarcinoma Interventions: Procedure: Biospecimen Collection; Procedure: Computed Tomography; Procedure: Distal Pancreatectomy; Procedure: Laparoscopy; Procedure: Magnetic Resonance Imaging; Procedure: Pancreaticoduodenectomy; Other: Questionnaire Administration; Procedure: Surgical Procedure; Procedure: Total Pancreatectomy Sponsors: University of Southern California; National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 15, 2023 Category: Research Source Type: clinical trials

Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in Initially Node Positive Breast Cancer Patients, Could it Omit Axillary Dissection ?
Conditions: Sentinel Lymph Node Interventions: Procedure: sentinle lymphnode biopsy Sponsors: Assiut University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 14, 2023 Category: Research Source Type: clinical trials

Conserving Surgery in Inflammatory Breast Cancer After Neoadjuvant Chemotherapy
Conditions: Inflammatory Breast Cancer Interventions: Procedure: Breast conserving surgery; Procedure: Radical modified mastectomy Sponsors: Fondazione Policlinico Universitario Agostino Gemelli IRCCS Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 14, 2023 Category: Research Source Type: clinical trials

Neoadjuvant Tirellizumab Combined With Chemotherapy for Early Oral Squamous Cell Carcinoma(HNC-SYSU-004)
Conditions: Oral Cancer; PD-1 Interventions: Drug: PD-1 with chemotherapy; Procedure: upright surgery Sponsors: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 14, 2023 Category: Research Source Type: clinical trials

An Exploration of Candidates for Neoadjuvant Treatment in Resectable Pancreatic Cancer
Conditions: Pancreatic Cancer; Neoadjuvant Interventions: Drug: Neoadjuvant treatment Sponsors: Seoul National University Hospital Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 13, 2023 Category: Research Source Type: clinical trials

Clinical Study of Taurine Combined With Neoadjuvant Chemo-Immunotherapy for Treatment of Locally Advanced Gastric Cancer
Conditions: Gastric Cancer Interventions: Dietary Supplement: Taurine; Biological: Serplulimab; Drug: XELOX regimen; Drug: FLOT regimen Sponsors: Tang-Du Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 13, 2023 Category: Research Source Type: clinical trials

Pembrolizumab in Combination With Eftilagimod Alpha and Radiotherapy in Neoadjuvant Treatment of Patients With Soft Tissue Sarcoma - EFTISARC-NEO Trial
Conditions: Neoadjuvant; Immunotherapy; Sarcoma,Soft Tissue; Radiation Therapy Interventions: Drug: Pembrolizumab, Eftilagimod alpha Sponsors: Maria Sklodowska-Curie National Research Institute of Oncology; Immutep S.A.S. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 13, 2023 Category: Research Source Type: clinical trials

A Prospective, Single-arm Phase II Clinical Trial of Tislelizumab Combined With Platinum Doublet Neoadjuvant Therapy to Improve Mandibular Preservation in Resectable Locally Advanced Oral Squamous Cell Carcinoma.
Conditions: Oral Squamous Cell Carcinoma Interventions: Drug: Three-Week Treatment Regimen with Trastuzumab in Combination with Docetaxel and Platinum Triple Therapy Sponsors: Xuekui Liu Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 13, 2023 Category: Research Source Type: clinical trials

A Phase III, Active-Controlled Study of SHR-A1811 Versus Trastuzumab Emtansine (T-DM1) in HER2-Positive Primary Breast Cancer Participants With Residual Invasive Disease Following Neoadjuvant Therapy
Conditions: HER2-Positive Primary Breast Cancer Participants With Residual Invasive Disease Following Neoadjuvant Therapy Interventions: Drug: SHR-A1811; Drug: Trastuzumab Emtansine Sponsors: Jiangsu HengRui Medicine Co., Ltd. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 10, 2023 Category: Research Source Type: clinical trials

Evaluation of the Efficacy and Safety of Bevacizumab Combined With PD-1 Monoclonal Antibody in Preoperative Neoadjuvant Therapy for MSS Colorectal Cancer With Liver Metastases
Conditions: Colorectal Cancer Interventions: Drug: Bevacizumab Combined With PD-1 Monoclonal Antibody Sponsors: The First Affiliated Hospital with Nanjing Medical University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 9, 2023 Category: Research Source Type: clinical trials

PABLIXIMAB as Neoadjuvant Therapy for Head and Neck Squamous-cell Carcinoma
Conditions: Squamous Cell Carcinoma of Head and Neck; Neoadjuvant Therapy; Immunotherapy Sponsors: Xijing Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 9, 2023 Category: Research Source Type: clinical trials

Neoadjuvant Tislelizumab With Chemotherapy for the Treatment of MSS Colon Cancer
Conditions: Colonic Neoplasms; Neoadjuvant Therapy; Immune Checkpoint Inhibitors Interventions: Drug: Anti-PD-1 monoclonal antibody; Drug: Oxaliplatin; Drug: Capecitabine 500 MG; Procedure: Colectomy Sponsors: First Affiliated Hospital of Guangxi Medical University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 9, 2023 Category: Research Source Type: clinical trials

Phase I Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes as Neoadjuvant Therapy for HER2-Negative Breast Cancer
Conditions: Breast Neoplasms Interventions: Procedure: Sentinel Lymph Node Biopsy (SLNB); Drug: Doxorubicin; Drug: Epirubicin; Drug: Cyclophosphamide; Drug: Cyclophosphamide; Drug: Fludarabine; Biological: Tumor-draining lymph node-derived lymphocyte (LNL); Biological: Interleukin-2; Drug: Nab-paclitaxel Sponsors: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 8, 2023 Category: Research Source Type: clinical trials

New Prognostic Index for Neoadjuvant Chemotherapy Outcome in Patients With Advanced High-grade Serous Ovarian Cancer
Conditions: Ovarian Cancer; Neoadjuvant Chemotherapy; Prognostic Cancer Model Interventions: Diagnostic Test: CRS scoring; Diagnostic Test: Routine blood laboratory testing before treatment Sponsors: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University Enrolling by invitation (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 7, 2023 Category: Research Source Type: clinical trials

Neoadjuvant Immune-based Combinations in Patients Undergoing Nephrectomy for Locally Advanced ccRCC
Conditions: Neoplasms; Kidney Neoplasms; Urologic Neoplasms; Urogenital Neoplasms; Female Urogenital Diseases; Urogenital Diseases; Kidney Diseases; Urologic Diseases; Male Urogenital Diseases; Carcinoma; Carcinoma, Renal Cell; Antineoplastic Agents; Immune Checkpoint Inhibitors Interventions: Drug: Toripalimab; Drug: Axitinib; Drug: Lenvatinib; Drug: Sunitinib Sponsors: Jinling Hospital, China Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 2, 2023 Category: Research Source Type: clinical trials