Fight Aging! Newsletter, January 15th 2024
In conclusion, FMD cycles have high potential to be effective in increasing the toxicity of a range of therapies against ALL and other blood cancers and should be tested in randomized clinical trials, especially in combination with immunotherapy and low toxicity cancer therapies.
In summary, we present a new strategy for improving leukemia treatment by combining FMD with chemotherapy to promote the killing of ALL cells in part by an immune-dependent mechanism. Fasting/FMD has been shown to reduce chemotherapy-associated toxicity in pre-clinical and clinical studies and thus represents a safe and potentially effectiv...
Source: Fight Aging! - January 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Continued Assessment of the Fasting Mimicking Diet as an Adjuvant Cancer Therapy
In conclusion, FMD cycles have high potential to be effective in increasing the toxicity of a range of therapies against ALL and other blood cancers and should be tested in randomized clinical trials, especially in combination with immunotherapy and low toxicity cancer therapies.
In summary, we present a new strategy for improving leukemia treatment by combining FMD with chemotherapy to promote the killing of ALL cells in part by an immune-dependent mechanism. Fasting/FMD has been shown to reduce chemotherapy-associated toxicity in pre-clinical and clinical studies and thus represents a safe and potentially effectiv...
Source: Fight Aging! - January 12, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Evaluation of the Surgical Specimen After Neoadjuvant Systemic Therapy
ConclusionPostneoadjuvant systemic therapy histopathological changes are complex, and careful systematic review of the specimen is required for accurate diagnosis and follow-up treatment. For pathological complete response to be used as an indicator of response to novel therapies, it is essential to have a standardized way in which residual disease is measured and reported. We designed the recommendations specifically for the clinical trial setting; however, they can be optionally incorporated into routine practice because, in our opinion, standardization is most effective when uniformly applied. Hopefully, such standardiz...
Source: Oncopathology - March 23, 2021 Category: Cancer & Oncology Tags: breast Breast Biopsy Procedure breast cancer Source Type: blogs
Fight Aging! Newsletter, September 28th 2020
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results.
Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - September 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fasting Mimicking Diet Improves Chemotherapy Effectiveness and Reduces Side Effects
The fasting mimicking diet emerged from efforts to better define the dose-response curve for beneficial effects resulting from a reduced calorie intake. Fasting is beneficial, calorie restriction is beneficial, but where are the dividing lines? How much food can one eat and still obtain near all of the benefits of fasting? As a result of this work, the fasting mimicking diet has undergone clinical testing in cancer patients. Numerous benefits have been demonstrated, and the paper here is an example of the type. In this human trial, fasting mimicking reduced the negative short term impact of chemotherapy on health, and, fur...
Source: Fight Aging! - September 22, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Last Couple of Months in Oncology with Dr. Bishal Gyawali: March 2019
By BISHAL GYAWALI MD, PhD
Hey, I’m back!
Well, you might not have noticed that my blogs were missing for the last three months but anyways, its good to be back. I was having a little time off blogs and social media as I was transitioning in my career but now I am back. Sometimes, it is very difficult to manage time for things that you must do versus things you enjoy doing, especially when these two don’t intersect. For me, these last few months the things I had to do were all bureaucratic while I couldn’t find the time for things I enjoy doing like writing these blogs. But now that we are back, let’s rec...
Source: The Health Care Blog - March 26, 2019 Category: Consumer Health News Authors: Matthew Holt Tags: Medical Practice Physicians Bishal Gyawali Cancer drugs Clinical Trials Oncology Prostate Cancer RCTs Source Type: blogs
The Skeptical Oncologist
By BISHAL GYAWALI, MD
Why conduct post approval studies at all?
Atezolizumab previously received accelerated approval in second-line metastatic or advanced urothelial cancer based on response rates from a single arm trial. The results of post approval confirmatory phase 3 are now published and demonstrate that atezolizumab did not improve survival versus chemotherapy (11.1 v 10.6 months, HR 0.87, p = 0.41). The concept of accelerated approval is to grant early and conditional approval and access to drugs in diseases of unmet need, and that the decision to fully approve or revoke be made based on results of confirmato...
Source: The Health Care Blog - February 7, 2018 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs
New Research Which Could Have More Thought
This study did not include women who had mastectomies or suspicious or enlarged lymph nodes in a physical exam." To make sure that women have the appropriate lymph node surgery, the American Society for Clinical Oncology released guidelines on sentinel lymph node biopsy for people diagnosed with early-stage breast cancer. The guidelines say sentinel lymph node biopsy SHOULD be offered under these circumstances:breast cancer in which there is more than one tumor, all of which have formed separately from one another (doctors call these multicentric tumors); these types of breast cancers are rareDCIS treated with mastectomywo...
Source: Caroline's Breast Cancer Blog - October 8, 2017 Category: Cancer & Oncology Tags: breast cancer breast cancer treatment young cancer patients Source Type: blogs
Why a case report being circulated by advocates doesn ’ t show that the ketogenic diet combats cancer
it's October, which means that it's Breast Cancer Awareness Month, which means that it's time for dubious breast cancer case reports. Here's one about ketogenic diets that doesn't show that such diets cure cancer. (Source: Respectful Insolence)
Source: Respectful Insolence - October 4, 2017 Category: Surgery Authors: Orac Tags: Cancer Clinical trials Complementary and alternative medicine Skepticism/critical thinking breast cancer chemotherapy Ketogenic diet neoadjuvant chemotherapy Thomas Seyfried triple negative breast cancer Source Type: blogs
Why a case report being circulated by advocates doesn ’ t show that the ketogenic diet combats cancer
it's October, which means that it's Breast Cancer Awareness Month, which means that it's time for dubious breast cancer case reports. Here's one about ketogenic diets that doesn't show that such diets cure cancer.
The post Why a case report being circulated by advocates doesn’t show that the ketogenic diet combats cancer appeared first on RESPECTFUL INSOLENCE. (Source: Respectful Insolence)
Source: Respectful Insolence - October 4, 2017 Category: Surgery Authors: Orac Tags: Cancer Clinical trials Complementary and alternative medicine Skepticism/critical thinking breast cancer chemotherapy Ketogenic diet neoadjuvant chemotherapy Thomas Seyfried triple negative breast cancer Source Type: blogs
Why a case report being circulated by advocates doesn't show that the ketogenic diet combats cancer
In conclusion, this combined metabolic approach appears effective in treating advanced TNBC, given this patient’s complete response with a good quality of life.Now, there is one thing that is interesting here. The doses of chemotherapy used were considerably lower thanwhat is usually used, with doses decreased by at least half or more. Does this mean anything? Who knows? cPR rates for TNBC have been reported to range from 20-35%. It could mean the regimen made the chemotherapy more effective, or it could mean that this woman just happened to have a particularly chemosensitive tumor. Even if we take this case report at fa...
Source: Respectful Insolence - October 4, 2017 Category: Surgery Authors: oracknows Source Type: blogs
Why a case report being circulated by advocates doesn't show that the ketogenic diet combats cancer
In conclusion, this combined metabolic approach appears effective in treating advanced TNBC, given this patient’s complete response with a good quality of life.Now, there is one thing that is interesting here. The doses of chemotherapy used were considerably lower thanwhat is usually used, with doses decreased by at least half or more. Does this mean anything? Who knows? cPR rates for TNBC have been reported to range from 20-35%. It could mean the regimen made the chemotherapy more effective, or it could mean that this woman just happened to have a particularly chemosensitive tumor. Even if we take this case report at fa...
Source: Respectful Insolence - October 4, 2017 Category: Surgery Authors: oracknows Source Type: blogs
A cancer patient ’s incredible response to treatment
I’d known her for almost 3 years. She had advanced ovarian cancer — clear cell — and was diagnosed with disease already in her chest, stage IV. She had a terrific response to neoadjuvant chemotherapy, which had resolved her extra-abdominal disease sites after three cycles. She had an aggressive interval surgery which achieved complete resection of residual cancer (an R0 resection). She had completed adjuvant chemotherapy, and I declared her to be in remission at that time. But it was short-lived; within four months, her disease had returned. Platinum resistance, we call it. We started a new regimen then ̵...
Source: Kevin, M.D. - Medical Weblog - August 9, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/don-s-dizon" rel="tag" > Don S. Dizon, MD < /a > Tags: Physician Cancer OB/GYN Source Type: blogs
Stop Changing Your Mind Please
[A breast cancer tumor imaged with a technique that highlights aspects of its microenvironment.NATIONAL CANCER INSTITUTE/UNIV. OF CHICAGO COMPREHENSIVE CANCER CENTER]I really wish they would stop changing their mind. I know several women who have had chemo before surgery to reduce the size of their tumor. If you have a woman who has a fairly large tumor and chemo before surgery has the benefit of reducing their surgery - maybe from a mastectomy to a lumpectomy. This is actually a huge benefit. The surgery is so much less drastic. " The main goal of pre-operative (neoadjuvant) chemotherapy for breast cancer is to shrin...
Source: Caroline's Breast Cancer Blog - July 11, 2017 Category: Cancer & Oncology Tags: breast cancer treatment cancer research disappointment Source Type: blogs
