Neoadjuvant Trastuzumab, Pertuzumab and Tucatinib Without Chemotherapy in HER2-positive Breast Cancer: the TRAIN-4 Study
Conditions: Breast Cancer Interventions: Drug: Tucatinib; Drug: Trastuzumab; Drug: Pertuzumab Sponsors: The Netherlands Cancer Institute; Seagen Inc. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 8, 2023 Category: Research Source Type: clinical trials

Total Neoadjuvant Therapy in Rectal Cancer
Conditions: Rectal Cancer Interventions: Radiation: Short-course radiotherapy; Drug: mFOLFOX6 Sponsors: National Cheng-Kung University Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 8, 2023 Category: Research Source Type: clinical trials

Total Neoadjuvant Therapy for Adenocarcinoma of the OESophagus and Oesophagogastric Junction: TNT-OES-2 Trial
Conditions: Esophageal Cancer; Adenocarcinoma of the Esophagus Interventions: Drug: FLOT-CROSS or CROSS-FLOT Sponsors: Erasmus Medical Center Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 8, 2023 Category: Research Source Type: clinical trials

Cadonilimab + FOLFOX Versus FOLFOX in the Neoadjuvant Treatment of pMMR/MSS Locally Advanced Colorectal Cancer
Conditions: Locally Advanced Colorectal Carcinoma Interventions: Drug: Cadonilimab; Drug: FOLFOX regimen Sponsors: Cancer Institute and Hospital, Chinese Academy of Medical Sciences Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 4, 2023 Category: Research Source Type: clinical trials

Organoids Based Drug Sensitivity in Neoadjuvant Chemotherapy of Breast Cancer
Conditions: Organoids; Breast Cancer; Neoadjuvant Chemotherapy Interventions: Procedure: Biopsy Sponsors: Second Affiliated Hospital, School of Medicine, Zhejiang University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 4, 2023 Category: Research Source Type: clinical trials

Neoadjuvant PD-1 Inhibitor Combined With Cetuximab and Platinum in Resectable Locally Advanced Hypopharyngeal Carcinoma
Conditions: Locally Advanced Hypopharyngeal Carcinoma Interventions: Drug: three cycles (toripalimab + cetuximab + platinum); Procedure: Radical surgery; Radiation: Radiotherapy or chemoradiotherapy Sponsors: Eye& ENT Hospital of Fudan University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 30, 2023 Category: Research Source Type: clinical trials

Muscle Parameters and Pathological Response in Breast Cancer Patients
Conditions: Neoadjuvant Chemotherapy Interventions: Other: Neoadjuvant therapy Sponsors: Ac ıbadem Atunizade Hospital Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 30, 2023 Category: Research Source Type: clinical trials

Neoadjuvant Nivolumab and Relatlimab in Merkel Cell Carcinoma
Conditions: Merkel Cell Carcinoma Interventions: Drug: Nivolumab 240 mg / Relatlimab 80 mg in a fixed dose combination Sponsors: Melanoma Institute Australia; Bristol-Myers Squibb Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 30, 2023 Category: Research Source Type: clinical trials

Micrometastases in Axillary Lymph Nodes in Breast Cancer, Post-neoadjuvant Chemotherapy
Conditions: Micrometastases; Neoadjuvant Chemotherapy Interventions: Procedure: Sentinel lymph node biopsy, axillary lymph node dissection Sponsors: Gangnam Severance Hospital Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 29, 2023 Category: Research Source Type: clinical trials

Precision Treatment of Recurrent/Metastatic Salivary Gland Carcinoma Guided by Molecular-based Stagingcarcinoma
Conditions: Locally Advanced or Recurrent/Metastatic Salivary Gland Carcinoma; Neoadjuvant or Conversion Therapy; Precision Therapy Interventions: Drug: Vedolizumab; Drug: larotinib or enttraitinib; Drug: antiandrogen drug treatment; Drug: SHR-A1921; Drug: small molecule multi-target tyrosine kinase inhibitors; Drug: albumin paclitaxel with platinum Sponsors: Peking Union Medical College; Peking University Hospital of Stomatology Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 24, 2023 Category: Research Source Type: clinical trials

Response to Neoadjuvant Chemoimmunotherapy in Resectable Locally Advanced Oral Cancer
Conditions: Oral Cancer Interventions: Drug: PD-1 inhibitor+carboplatin+albumin-bound paclitaxel Sponsors: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 22, 2023 Category: Research Source Type: clinical trials

Neoadjuvant Pyrotinib Versus Placebo Combined With Chemotherapy in HR-positive and HER2-low Early Breast Cancer
Conditions: Breast Cancer Invasive; Hormone-receptor-positive Breast Cancer; HER2 Low Breast Carcinoma; Early-stage Breast Cancer Interventions: Drug: Pyrotinib, epirubicin or doxorubicin, cyclophosphamide, paclitaxel; Drug: Placebo, epirubicin or doxorubicin, cyclophosphamide, paclitaxel Sponsors: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University; Jiangsu HengRui Medicine Co., Ltd. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 22, 2023 Category: Research Source Type: clinical trials

Cadonilimab Combination With Lenvatinib as Neoadjuvant Therapy for ccRCC
Conditions: Cadonilimab; Clear Cell Renal Cell Carcinoma; Neoadjuvant Therapy Interventions: Drug: Cadonilimab Combined With Lenvatinib Sponsors: Sun Yat-sen University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 18, 2023 Category: Research Source Type: clinical trials

Liver Transplantation in Intrahepatic Cholangiocarcinoma
Conditions: Locally Advanced Non-metastatic Intrahepatic Cholangiocarcinoma; Determine Efficacy of Liver Transplantation After Neoadjuvant Systemic Therapy in Patients With Locally Advanced Non-metastatic Intrahepatic Cholangiocarcinoma Interventions: Procedure: Liver Transplant Sponsors: Rutgers, The State University of New Jersey Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 18, 2023 Category: Research Source Type: clinical trials

Dissecting the Pattern of Nodal Spread in Post-neoadjuvant Pancreatoduodenectomy
Conditions: Pancreas Cancer; Pancreatic Adenocarcinoma Interventions: Procedure: Systematic lymphadenectomy Sponsors: Universita di Verona Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 16, 2023 Category: Research Source Type: clinical trials