Fight Aging! Newsletter, October 7th 2019
In conclusion, our findings link the calcification of the vascular tissue with the expression of FGF23 in the vessels and with the elevation of circulating levels this hormone.
Permanently Boosting Levels of Natural Killer Cells in Mice to Increase Cancer Resistance
https://www.fightaging.org/archives/2019/09/permanently-boosting-levels-of-natural-killer-cells-in-mice-to-increase-cancer-resistance/
Researchers here demonstrate a very interesting approach to immunotherapy: they introduce engineered stem cells in mice that will give rise to additional natural killer T cells, boosting the capability of the...
Source: Fight Aging! - October 6, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Part 6 - Why Is Cancer Pain So Special?
by Drew Rosielle (@drosielle)A Series of Observations on Opioids By a Palliative Doc Who Prescribes A Lot of Opioids But Also Has Questions.This is the 5th post in a series about opioids, with a focus on how my thinking about opioids has changed over the years. See also:Part 1 – Introduction, General Disclaimers, Hand-Wringing, and a Hand-Crafted Graph.Part 2 – We Were Wrong 20 years Ago, Our Current Response to the Opioid Crisis is Wrong, But We Should Still Be Helping Most of our Long-Term Patients Reduce Their Opioid DosesPart 3 – Opioids Have Ceiling Effects, High-Doses are Rarely Therapeutic, and Another Hand-Cr...
Source: Pallimed: A Hospice and Palliative Medicine Blog - October 6, 2019 Category: Palliative Care Tags: cancer opioids pain rosielle The profession Source Type: blogs
Permanently Boosting Levels of Natural Killer Cells in Mice to Increase Cancer Resistance
Researchers here demonstrate a very interesting approach to immunotherapy: they introduce engineered stem cells in mice that will give rise to additional natural killer T cells, boosting the capability of the immune system for the entire life span of the mouse. Even if this class of treatment is not actually permanent in the same way in humans, and merely long-lasting, it still seems a promising step towards enhancing the immune system at any age, not just trying to repair it when it fails in later life.
They've been called the "special forces" of the immune system: invariant natural killer T cells. Although there...
Source: Fight Aging! - September 30, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
First Round of Carfilzomib and Cyclophosphamide Results
Even after all this time, I’m still not sure how to take the free light chains results. I’m not a science-y person. Dr. Rodriguez says that there’s been an improvement. This is the result from last week’s blood draw. Component Your Value Standard Range Free Kappa 3.19 mg/L 3.30 – 19.40 mg/L Free Lambda 163.95 … (Source: beth's myeloma blog)
Source: beth's myeloma blog - September 9, 2019 Category: Cancer & Oncology Authors: Beth Tags: carfilzomib cyclophosphamide Cytoxan Kyprolis Serum Free Light Chain Source Type: blogs
Wow, what a holiday!
Stefano and I returned from England almost a week ago, last Saturday evening, but since then I’ve had a million things to do, not just heaps of laundry, food shopping, and the usual household-related stuff (cat litter, cat this, cat that, cat everything!), but also getting together with my girlfriends, a very important part of my life!, AND planning my English lessons for next week.
I still need to fit my sessions at the rehab center into my weekly schedule. These are the workouts I still need to do both for my shoulder AND for my tendinitis, which actually behaved incredibly well after the first week or so on holi...
Source: Margaret's Corner - September 6, 2019 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll Lake District Peak District Sandsend Shambles Straithes Whitby York Source Type: blogs
Carfilzomib and Cytoxan
Well, the daratumumab and pomalyst train has left the station without me. My doctor decided that it wasn’t helping me anymore, so I’ve moved on. A few weeks ago I started carfilzomib (Kyprolis) and cyclophosphamide (Cytoxan). I also have 20 mg of dexamethasone every week. I have carfilzomib on Thursdays and Fridays and Cytoxan only … (Source: beth's myeloma blog)
Source: beth's myeloma blog - September 6, 2019 Category: Cancer & Oncology Authors: Beth Tags: cyclophosphamide daratumumab Dexamethasone Pomalyst Source Type: blogs
Test results
Just got home from picking up my most recent blood (and urine) test results. Okay, let’s see, there’s a lot of positive stuff to report.
Compared to my last tests, my M-spike and monoclonal component have gone down, my total IgG is also maintaining its downward trend, ESR is down, hey cholesterol is down, too…total protein, down…calcium and creatinine, no change (both still within normal range).
There are a couple of things that aren’t so good: 1. my hemoglobin is just under the normal range…again…I see a few steaks in my future, sigh; 2. my B2M is up (again) to 3, that is, slightl...
Source: Margaret's Corner - August 5, 2019 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll smoldering myeloma Source Type: blogs
More Coming
2019 July 31
I ' ll be posting again here soon.
Don (Source: Myeloma Hope)
Source: Myeloma Hope - July 31, 2019 Category: Cancer & Oncology Source Type: blogs
Myeloma Beatdown
Blogging again.
June 26, 2019.
After a lovely, easy, three-year ride on a two-drug myeloma
regimen, my right shoulder was hurting and a PET scan showed a lesion (a
collection of myeloma cells showing bright red) in my right scapula.
M-spike and IgG hadn ' t changed, but Lambda Light Chains had more than doubled.
The myeloma was back. It never gives up.
My Mayo doctor ordered radiation treatment of that lesion, and added
dexamethasone to the two-drug therapy. Now, a month later, the ten
radiation treatments are complete and I ' m taking the dex. Last week ' s
blood test showed Lambda light chains back down to normal again, ...
Source: Myeloma Hope - July 31, 2019 Category: Cancer & Oncology Tags: dexamethasone Lambda Light Chains myeloma non-secretory nonsecretory PET scan Radiation scapula Source Type: blogs
AI Platform for Cognitive Performance Training
This study, published in journal Advanced Therapeutics, describes the use of CURATE.AI for improving trainee performance on a US Air Force flight simulator program, a task that is very cognitively challenging.
In the past, the same research team used the CURATE.AI software to develop a personalized immunosuppressant dosing schedule after organ transplant, optimize drug discovery libraries, and study in vitro and in vivo models of disease, including multiple myeloma and tuberculosis.
In the study, participants underwent training with the flight simulator in low, medium, and high intensity levels. CURATE.AI characterized the...
Source: Medgadget - June 10, 2019 Category: Medical Devices Authors: Siavash Parkhideh Tags: Education Informatics Net News Psychiatry Source Type: blogs
No surgery!!!
Yesterday I went to the hospital to see an orthopedic surgeon who told me to use my left hand as much as possible from now on, so this morning I thought I’d give typing with two hands a try, even though my arm is still in a sling, of course, and I’m not supposed to move my left shoulder at all.
Yep, yep, yep, this works…for a short post, anyway…
The orthopedist told me that my fracture is borderline for surgery. I’d actually been told the same thing last Monday, so I knew surgery might be in the picture. Aggghhhh!!! For a moment, yesterday, I froze…
When I told her about my smoldering my...
Source: Margaret's Corner - May 29, 2019 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll Source Type: blogs
