Facioscapulohumeral muscular dystrophy Health Index: Japanese translation and validation study
CONCLUSIONS: The FSHD-HI-J is a valid and reliable patient-reported outcome measure for Japanese patients with FSHD. This validated, disease-specific patient-reported outcome is essential for future clinical practice and clinical trials.PMID:38555736 | DOI:10.1080/09638288.2024.2322035 (Source: Disability and Rehabilitation)
Source: Disability and Rehabilitation - March 31, 2024 Category: Rehabilitation Authors: Haruo Fujino Masanori P Takahashi Harumasa Nakamura Chad R Heatwole Hiroto Takada Satoshi Kuru Katsuhisa Ogata Kiyoka Enomoto Yuto Hayashi Osamu Imura Tsuyoshi Matsumura Source Type: research
Transcriptome-based deep learning analysis identifies drug candidates targeting protein synthesis and autophagy for the treatment of muscle wasting disorder
This study analyzed the gene expression signatures associated with cancer formation and 5-FU chemotherapy-induced muscle wasting. Our findings suggest that dimenhydrinate, a combination of 8-chlorotheophylline and diphenhydramine, is a potential therapeutic for sarcopenia. In vitro experiments demonstrated that dimenhydrinate promotes muscle progenitor cell proliferation through the phosphorylation of Nrf2 by 8-chlorotheophylline and promotes myotube formation through diphenhydramine-induced autophagy. Furthermore, in various in vivo sarcopenia models, dimenhydrinate induced rapid muscle tissue regeneration. It improved mu...
Source: Molecular Medicine - March 31, 2024 Category: Molecular Biology Authors: Min Hak Lee Bada Lee Se Eun Park Ga Eul Yang Seungwoo Cheon Dae Hoon Lee Sukyeong Kang Ye Ji Sun Yongjin Kim Dong-Sub Jung Wonwoo Kim Jihoon Kang Yi Rang Kim Jin Woo Choi Source Type: research
Efficacy and Tolerability of Ivabradine for Cardiomyopathy in Patients with Duchenne Muscular Dystrophy
Int Heart J. 2024;65(2):211-217. doi: 10.1536/ihj.23-563.ABSTRACTDuchenne muscular dystrophy (DMD) is an intractable X-linked myopathy caused by dystrophin gene mutations. Patients with DMD suffer from progressive muscle weakness, inevitable cardiomyopathy, increased heart rate (HR), and decreased blood pressure (BP). The aim of this study was to clarify the efficacy and tolerability of ivabradine treatment for DMD cardiomyopathy.A retrospective analysis was performed in 11 patients with DMD, who received ivabradine treatment for more than 1 year. Clinical results were analyzed before (baseline), 6 months after, and 12 mon...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Akiko Wakisaka Koichi Kimura Hiroyuki Morita Koki Nakanishi Masao Daimon Masanori Nojima Hideki Itoh Atsuhito Takeda Ruriko Kitao Tomihiro Imai Tetsuhiko Ikeda Takashi Nakajima Chigusa Watanabe Toshihiro Furukawa Ichiro Ohno Chiho Ishida Norihiko Takeda K Source Type: research
Facioscapulohumeral muscular dystrophy Health Index: Japanese translation and validation study
CONCLUSIONS: The FSHD-HI-J is a valid and reliable patient-reported outcome measure for Japanese patients with FSHD. This validated, disease-specific patient-reported outcome is essential for future clinical practice and clinical trials.PMID:38555736 | DOI:10.1080/09638288.2024.2322035 (Source: Disability and Rehabilitation)
Source: Disability and Rehabilitation - March 31, 2024 Category: Rehabilitation Authors: Haruo Fujino Masanori P Takahashi Harumasa Nakamura Chad R Heatwole Hiroto Takada Satoshi Kuru Katsuhisa Ogata Kiyoka Enomoto Yuto Hayashi Osamu Imura Tsuyoshi Matsumura Source Type: research
Efficacy and Tolerability of Ivabradine for Cardiomyopathy in Patients with Duchenne Muscular Dystrophy
Int Heart J. 2024;65(2):211-217. doi: 10.1536/ihj.23-563.ABSTRACTDuchenne muscular dystrophy (DMD) is an intractable X-linked myopathy caused by dystrophin gene mutations. Patients with DMD suffer from progressive muscle weakness, inevitable cardiomyopathy, increased heart rate (HR), and decreased blood pressure (BP). The aim of this study was to clarify the efficacy and tolerability of ivabradine treatment for DMD cardiomyopathy.A retrospective analysis was performed in 11 patients with DMD, who received ivabradine treatment for more than 1 year. Clinical results were analyzed before (baseline), 6 months after, and 12 mon...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Akiko Wakisaka Koichi Kimura Hiroyuki Morita Koki Nakanishi Masao Daimon Masanori Nojima Hideki Itoh Atsuhito Takeda Ruriko Kitao Tomihiro Imai Tetsuhiko Ikeda Takashi Nakajima Chigusa Watanabe Toshihiro Furukawa Ichiro Ohno Chiho Ishida Norihiko Takeda K Source Type: research
