Botensilimab Plus Balstilimab and Fasting Mimicking Diet Plus Vitamin C for Patients With KRAS-Mutant Metastatic Colorectal Cancer
Conditions: Metastatic Colorectal Adenocarcinoma; Stage IV Colorectal Cancer AJCC v8 Interventions: Biological: Balstilimab; Procedure: Biospecimen Collection; Biological: Botensilimab; Procedure: Computed Tomography; Other: Dietary Intervention; Procedure: Magnetic Resonance Imaging; Dietary Supplement: Vitamin C Sponsors: University of Southern California; National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 29, 2024 Category: Research Source Type: clinical trials
Evaluation of Brain Waste Clearance Pathways Using Magnetic Resonance Imaging in Pediatric Patients With White Matter Diseases
Conditions: Glymphatic System; White Matter Disease; Pediatric Disorder; Perivascular Disease Interventions: Diagnostic Test: Magnetic resonance imaging Sponsors: IRCCS Eugenio Medea Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 28, 2024 Category: Research Source Type: clinical trials
The Fingerprinting of Inherited Leukoencephalopathies: A New Brain Imaging, Genetic and Clinical Assessment
Conditions: Leukoencephalopathies Interventions: Diagnostic Test: Brain quantitative magnetic resonance imaging Sponsors: IRCCS Fondazione Stella Maris; Oasi Research Institute-IRCCS; Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta; IRCCS Ospedale San Raffaele Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 27, 2024 Category: Research Source Type: clinical trials
Effects of Relugolix vs Leuprolide on Cardiac Function in Patients With Prostate Cancer
Conditions: Prostate Adenocarcinoma; Stage IIB Prostate Cancer AJCC v8; Stage IIC Prostate Cancer AJCC v8 Interventions: Procedure: Biospecimen Collection; Other: Contrast Agent; Drug: Leuprolide; Procedure: Magnetic Resonance Imaging; Other: Physical Performance Testing; Drug: Relugolix Sponsors: Ohio State University Comprehensive Cancer Center; Pfizer; Myovant Sciences GmbH; Sumitomo Pharmaceuticals America Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 26, 2024 Category: Research Source Type: clinical trials
Testing the Combination of Anti-cancer Drugs Tiragolumab and Atezolizumab to Improve Outcomes for Patients With Recurrent Glioblastoma
Conditions: Recurrent Glioblastoma, IDH-Wildtype Interventions: Biological: Atezolizumab; Procedure: Biospecimen Collection; Procedure: Magnetic Resonance Imaging; Procedure: Surgical Procedure; Biological: Tiragolumab Sponsors: National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 25, 2024 Category: Research Source Type: clinical trials
Arginine and Whole Brain Radiation Therapy for the Treatment of Patients With Brain Metastases
Conditions: Metastatic Malignant Neoplasm in the Brain; Metastatic Malignant Solid Neoplasm Interventions: Dietary Supplement: Arginine; Procedure: Biospecimen Collection; Procedure: Computed Tomography; Procedure: Magnetic Resonance Imaging; Procedure: Spectroscopy; Radiation: Whole-Brain Radiotherapy Sponsors: Emory University; National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 25, 2024 Category: Research Source Type: clinical trials
Evaluating Changes in Quality of Life After Near Margin-less Adaptive Radiation Therapy Compared to Standard Stereotactic Ablative Body Radiotherapy in Localized Prostate Cancer
Conditions: Localized Prostate Adenocarcinoma; Stage I Prostate Cancer AJCC v8; Stage II Prostate Cancer AJCC v8; Stage III Prostate Cancer AJCC v8 Interventions: Procedure: Computed Tomography; Procedure: Cone-Beam Computed Tomography; Radiation: Image-Guided Adaptive Radiation Therapy; Procedure: Magnetic Resonance Imaging; Procedure: Stereotactic Ablative Radiotherapy; Other: Survey Administration Sponsors: Mayo Clinic Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 22, 2024 Category: Research Source Type: clinical trials
Well-Formulated Ketogenic Diet Polycystic Kidney Disease
Conditions: Polycystic Kidney Disease Interventions: Other: Ketogenic Diet; Biological: Ketone/Glucose Monitoring; Biological: CGM/CKM; Biological: Blood Draw; Other: Body Composition; Other: Change in glomerular filtration rate (mg/mmol) via magnetic resonance imaging (MRI) . Sponsors: Ohio State University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 22, 2024 Category: Research Source Type: clinical trials
Anti-Lag-3 (Relatlinib) and Anti-PD-1 Blockade (Nivolumab) Versus Standard of Care (Lomustine) for the Treatment of Patients With Recurrent Glioblastoma
Conditions: Recurrent Glioblastoma Interventions: Procedure: Biopsy; Procedure: Biospecimen Collection; Drug: Lomustine; Procedure: Magnetic Resonance Imaging; Biological: Nivolumab; Biological: Relatlimab; Procedure: Surgical Procedure Sponsors: National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 22, 2024 Category: Research Source Type: clinical trials
Axatilimab in Combination With Retifanlimab and Paclitaxel for the Treatment of Patients With Advanced or Metastatic Solid Tumors
Conditions: Advanced Malignant Solid Neoplasm; Metastatic Malignant Solid Neoplasm; Recurrent Malignant Solid Neoplasm; Refractory Malignant Solid Neoplasm Interventions: Biological: Axatilimab; Procedure: Biopsy; Procedure: Biospecimen Collection; Procedure: Computed Tomography; Procedure: Magnetic Resonance Imaging; Drug: Paclitaxel; Procedure: Positron Emission Tomography; Biological: Retifanlimab Sponsors: OHSU Knight Cancer Institute; Oregon Health and Science University; Incyte Corporation Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 20, 2024 Category: Research Source Type: clinical trials
Identifying Findings on Brain Scans That Could Help Make Better Predictions About Brain Cancer Progression, The GABLE Trial
Conditions: Glioblastoma, IDH-Wildtype Interventions: Procedure: Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging; Other: Fluciclovine F18; Drug: Gadolinium-Chelate; Procedure: Magnetic Resonance Spectroscopy; Procedure: Positron Emission Tomography Sponsors: ECOG-ACRIN Cancer Research Group Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 19, 2024 Category: Research Source Type: clinical trials
Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia
Conditions: Acute Leukemia of Ambiguous Lineage; B Acute Lymphoblastic Leukemia Interventions: Drug: Asparaginase Erwinia chrysanthemi; Procedure: Biospecimen Collection; Biological: Blinatumomab; Procedure: Bone Marrow Aspiration; Drug: Calaspargase Pegol; Procedure: Computed Tomography; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Daunorubicin; Drug: Dexamethasone; Drug: Doxorubicin; Procedure: Echocardiography; Procedure: FDG-Positron Emission Tomography; Drug: Leucovorin; Procedure: Lumbar Puncture; Procedure: Magnetic Resonance Imaging; Drug: Mercaptopurine; Drug: Methotrexate; Procedure: Multigated Acquisition Sca...
Source: ClinicalTrials.gov - March 19, 2024 Category: Research Source Type: clinical trials
An Interactive Time-Restricted Diet Intervention (txt4fasting) for Reducing Neurocognitive Decline and Improving Survival in Patients With Brain Metastases From Breast or Lung Cancer
Conditions: Anatomic Stage IV Breast Cancer AJCC v8; Metastatic Breast Carcinoma; Metastatic Lung Carcinoma; Metastatic Malignant Neoplasm in the Brain; Stage IV Lung Cancer AJCC v8 Interventions: Behavioral: Behavioral Dietary Intervention; Other: Text Message-Based Navigation Intervention; Other: Internet-Based Intervention; Behavioral: Dietary Counseling and Surveillance; Radiation: Stereotactic Radiosurgery; Procedure: Biospecimen Collection; Procedure: Magnetic Resonance Imaging; Other: Neurocognitive Assessment; Other: Questionnaire Administration; Other: Interview; Other: Internet-Based Intervention; Radiation: Ster...
Source: ClinicalTrials.gov - March 18, 2024 Category: Research Source Type: clinical trials
Venetoclax for the Treatment of Patients With Relapsed Hairy Cell Leukemia
Conditions: Recurrent Hairy Cell Leukemia; Recurrent Hairy Cell Leukemia Variant Interventions: Procedure: Biospecimen Collection; Procedure: Bone Marrow Aspiration; Procedure: Bone Marrow Biopsy; Procedure: Computed Tomography; Procedure: Magnetic Resonance Imaging; Drug: Venetoclax Sponsors: National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2024 Category: Research Source Type: clinical trials
Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)
Conditions: Advanced Malignant Solid Neoplasm; Metastatic Malignant Solid Neoplasm Interventions: Procedure: Biopsy; Procedure: Biospecimen Collection; Procedure: Computed Tomography; Procedure: Echocardiography; Other: Electronic Health Record Review; Drug: Enfortumab Vedotin; Other: Immunohistochemistry Staining Method; Procedure: Magnetic Resonance Imaging; Procedure: Multigated Acquisition Scan; Biological: Sacituzumab Govitecan; Biological: Trastuzumab Deruxtecan Sponsors: National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2024 Category: Research Source Type: clinical trials
