Effects of a single dose of amisulpride on functional brain changes during reward- and motivation-related processing using task-based fMRI in healthy subjects and patients with major depressive disorder — study protocol for a randomized clinical trial
This study broadly covers all aspects of reward- and motivation-related processing as categorized by the National Institute of Mental Health Research Domain Criteria and is thereby an important step towards precision psychiatry. Results regarding the immediate effects of a dopaminergic drug on deficits in reward- and motivation-related processing not only have the potential to significantly broaden our understanding of underlying neurobiological processes but might eventually also pave the way for new treatment options.Trial registrationClinicalTrials.gov NCT05347199. April 12, 2022. (Source: Trials)
Source: Trials - November 27, 2023 Category: Research Source Type: clinical trials
Concealed Myocardial Abnormalities by Cardiac Magnetic Resonance Imaging in Idiopathic VT
Conditions: Premature Ventricular Contractions Interventions: Procedure: catheter based ablation Sponsors: Assiut University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 24, 2023 Category: Research Source Type: clinical trials
Rationale and design of a randomized clinical trial evaluating the efficacy of mechanical neuroprotection in reducing the risk of silent brain infarcts associated with percutaneous left atrial appendage closure: study protocol for a LAAC-SBI trial
DiscussionIf the study demonstrates a favorable outcome with reduced incidence of SBI and improved cognitive and mood outcomes in patients receiving cerebral protection devices during LAAC, it will have significant implications for clinical management standards. This would support the use of neuroprotection devices not only for LAAC but also in procedures such as atrial fibrillation ablation or transcatheter mitral valve interventions, where the risk of embolic events and subsequent brain injury may also be present.Trial registrationClinicalTrials.gov NCT05369195. Registration on 11.05.2022. (Source: Trials)
Source: Trials - November 23, 2023 Category: Research Source Type: clinical trials
Dose-Dependent Effect of Intranasal Insulin in Humans Using Functional Magnetic Resonance Imaging (fMRI)
Conditions: Healthy Interventions: Drug: Intranasal insulin Sponsors: Florian Schmitzberger Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 22, 2023 Category: Research Source Type: clinical trials
Pembrolizumab After Radiation Therapy and Chemotherapy in Limited Stage Small Cell Lung Cancer
Conditions: Limited Stage Lung Small Cell Carcinoma; Stage I Lung Cancer; Stage II Lung Cancer; Stage III Lung Cancer Interventions: Drug: Cisplatin; Drug: Carboplatin; Drug: Etoposide; Biological: Pembrolizumab; Procedure: Computed Tomography; Procedure: Positron Emission Tomography; Procedure: Magnetic Resonance Imaging; Procedure: Biospecimen Collection; Radiation: Radiation Therapy Sponsors: Vanderbilt-Ingram Cancer Center; Merck Sharp& Dohme LLC Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 20, 2023 Category: Research Source Type: clinical trials
Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis
Conditions: Breast Carcinoma; Metastatic Malignant Neoplasm in the Brain; Metastatic Malignant Neoplasm in the Leptomeninges Interventions: Procedure: Biospecimen Collection; Procedure: Computed Tomography; Procedure: Magnetic Resonance Imaging; Radiation: Radiation Therapy; Procedure: Resection; Drug: Trotabresib; Drug: Vinorelbine Sponsors: Northwestern University; National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 17, 2023 Category: Research Source Type: clinical trials
A Study to Learn More About the Safety and the Blood Level of BAY1747846 Given as Injection Into the Vein at Increasing Single Doses in Chinese Healthy Male Participants
Conditions: Contrast Enhancement in Magnetic Resonance Imaging; Healthy Volunteers Interventions: Drug: Gadoquatrane (BAY1747846) 0.03 mmol Gd/kg; Drug: Gadoquatrane (BAY1747846) 0.1 mmol Gd/kg; Drug: Matching placebo Sponsors: Bayer Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 16, 2023 Category: Research Source Type: clinical trials
Neurofeedback Enhanced Cognitive Reappraisal Training
Conditions: Anxiety; Social Anxiety Disorder; Panic Disorder; Generalized Anxiety Disorder Interventions: Device: Functional magnetic resonance imaging (fMRI) with Veritable-NF; Device: fMRI with Sham-NF Sponsors: University of Michigan; Brain& Behavior Research Foundation Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 15, 2023 Category: Research Source Type: clinical trials
PROACTIVE: Surgical Resection Outcomes in Locally Advanced and Unresectable Pancreatic Cancer After Neoadjuvant Chemotherapy
Conditions: Locally Advanced Pancreatic Adenocarcinoma; Stage III Pancreatic Cancer American Joint Committee on Cancer v8; Unresectable Pancreatic Adenocarcinoma Interventions: Procedure: Biospecimen Collection; Procedure: Computed Tomography; Procedure: Distal Pancreatectomy; Procedure: Laparoscopy; Procedure: Magnetic Resonance Imaging; Procedure: Pancreaticoduodenectomy; Other: Questionnaire Administration; Procedure: Surgical Procedure; Procedure: Total Pancreatectomy Sponsors: University of Southern California; National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 15, 2023 Category: Research Source Type: clinical trials
A Study to Evaluate Biomarker Signature to Predict the Persistence of Post-traumatic Headache
Conditions: Post-Traumatic Headache; Healthy Interventions: Diagnostic Test: Brain Magnetic Resonance Imaging (MRI) Scan; Other: Speech Sample; Other: Electronic Daily Headache Diary Sponsors: Mayo Clinic; National Institute of Neurological Disorders and Stroke (NINDS); Arizona State University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 15, 2023 Category: Research Source Type: clinical trials
Post-Operative Dosing of Dexamethasone in Patients With Brain Tumors After a Craniotomy, PODS Trial
Conditions: Low Grade Glioma; Malignant Brain Glioma; Malignant Brain Neoplasm; Meningioma Interventions: Procedure: Biospecimen Collection; Procedure: Computed Tomography; Drug: Dexamethasone; Procedure: Magnetic Resonance Imaging; Other: Questionnaire Administration Sponsors: Emory University; National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 15, 2023 Category: Research Source Type: clinical trials
Immune Response Activation for the Treatment of Unresectable Metastatic Colorectal Cancer or CEA Positive Metastatic Breast Cancer
Conditions: Breast Carcinoma; Colorectal Carcinoma Interventions: Procedure: Biopsy; Procedure: Biospecimen Collection; Procedure: Bone Scan; Procedure: Computed Tomography; Drug: Immunotherapy; Procedure: Magnetic Resonance Imaging; Procedure: Positron Emission Tomography; Radiation: Stereotactic Body Radiation Therapy Sponsors: City of Hope Medical Center; National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 14, 2023 Category: Research Source Type: clinical trials
A Study of Single Fraction Stereotactic Body Radiation Therapy (SBRT) Guided by Magnetic Resonance Imaging (MRI) in People With Liver Metastasis From Colorectal Cancer
Conditions: Colorectal Cancer; Liver Metastases Interventions: Radiation: MR Guided Single Fraction Stereotactic Body Radiation Therapy (SBRT) Sponsors: Memorial Sloan Kettering Cancer Center; Elekta Limited Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 14, 2023 Category: Research Source Type: clinical trials
Relugolix in Combination With Radiation Therapy for Treating Patients With High Risk Prostate Cancer
Conditions: Stage IIC Prostate Cancer AJCC v8; Stage III Prostate Cancer AJCC v8; Stage IV Prostate Cancer AJCC v8 Interventions: Procedure: Biospecimen Collection; Procedure: Bone Scan; Radiation: Brachytherapy; Procedure: Computed Tomography; Procedure: Dual X-ray Absorptiometry; Radiation: External Beam Radiation Therapy; Procedure: Magnetic Resonance Imaging; Procedure: PSMA PET Scan; Other: Questionnaire Administration; Drug: Relugolix Sponsors: University of Kansas Medical Center; National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 13, 2023 Category: Research Source Type: clinical trials
Prostate Resection After Microwave Ablation (PRAMA)
Conditions: Prostate Carcinoma Interventions: Procedure: Biospecimen Collection; Device: Microwave Ablation; Device: Multiparametric Magnetic Resonance Imaging; Other: Questionnaire Administration; Procedure: Radical Prostatectomy Sponsors: University of Southern California; National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 13, 2023 Category: Research Source Type: clinical trials
